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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for DUXA
Z-value: 1.17
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Transcription factors associated with DUXA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DUXA | hg19_v2_chr19_-_57678811_57678811 | 0.49 | 3.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_27998689 Show fit | 2.08 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr1_+_95616933 Show fit | 2.01 |
ENST00000604203.1
|
TMEM56-RWDD3 readthrough |
|
| chr12_-_91546926 Show fit | 1.89 |
ENST00000550758.1
|
decorin |
|
| chr10_-_112255945 Show fit | 1.54 |
ENST00000609514.1
ENST00000607952.1 |
RP11-525A16.4 |
|
| chr2_+_228678550 Show fit | 1.52 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr17_+_61151306 Show fit | 0.98 |
ENST00000580068.1
ENST00000580466.1 |
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
|
| chr15_-_34447023 Show fit | 0.94 |
ENST00000560310.1
|
katanin p80 subunit B-like 1 |
|
| chr12_+_72061563 Show fit | 0.92 |
ENST00000551238.1
|
THAP domain containing, apoptosis associated protein 2 |
|
| chr7_+_30589829 Show fit | 0.79 |
ENST00000579437.1
|
RP4-777O23.1 |
|
| chr2_+_161993465 Show fit | 0.78 |
ENST00000457476.1
|
TRAF family member-associated NFKB activator |
Network of associatons between targets according to the STRING database.
First level regulatory network of DUXA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.2 | 1.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.5 | 1.5 | GO:0045360 | interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
| 0.2 | 1.3 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 1.2 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.1 | 1.1 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.1 | 1.0 | GO:1990034 | cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034) |
| 0.0 | 1.0 | GO:0006004 | fucose metabolic process(GO:0006004) |
| 0.1 | 0.8 | GO:0018103 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 0.8 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 1.4 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.1 | 1.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.7 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.7 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 0.6 | GO:0031417 | NatC complex(GO:0031417) |
| 0.0 | 0.6 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.0 | 0.6 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.6 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.5 | 1.5 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
| 0.1 | 1.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.2 | 1.3 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 1.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.0 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 0.9 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 0.8 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 0.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.7 | GO:0098599 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 0.9 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.7 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.6 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |