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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for DPRX
Z-value: 1.34
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Transcription factors associated with DPRX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DPRX | hg19_v2_chr19_+_54135310_54135310 | -0.58 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_321340 Show fit | 10.59 |
ENST00000526811.1
|
interferon induced transmembrane protein 3 |
|
| chr11_-_321050 Show fit | 5.09 |
ENST00000399808.4
|
interferon induced transmembrane protein 3 |
|
| chr12_+_113344755 Show fit | 1.19 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_+_113344582 Show fit | 1.12 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr1_+_66796401 Show fit | 0.73 |
ENST00000528771.1
|
phosphodiesterase 4B, cAMP-specific |
|
| chr4_+_89299885 Show fit | 0.73 |
ENST00000380265.5
ENST00000273960.3 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr12_+_113344811 Show fit | 0.67 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_+_6949964 Show fit | 0.64 |
ENST00000541978.1
ENST00000435982.2 |
guanine nucleotide binding protein (G protein), beta polypeptide 3 |
|
| chr1_-_150208320 Show fit | 0.59 |
ENST00000534220.1
|
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
|
| chr5_+_63461642 Show fit | 0.56 |
ENST00000296615.6
ENST00000381081.2 ENST00000389100.4 |
ring finger protein 180 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DPRX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 15.7 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 2.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.3 | 1.0 | GO:1902544 | regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.1 | 1.0 | GO:1901078 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 0.8 | GO:0007023 | post-chaperonin tubulin folding pathway(GO:0007023) |
| 0.1 | 0.7 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.7 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.1 | 0.5 | GO:0018262 | isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262) |
| 0.1 | 0.5 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.0 | 0.5 | GO:0015727 | lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.7 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.6 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 0.4 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 0.3 | GO:0005715 | late recombination nodule(GO:0005715) |
| 0.1 | 0.3 | GO:0030906 | retromer, cargo-selective complex(GO:0030906) |
| 0.0 | 0.3 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.3 | 1.0 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.0 | 0.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.1 | 0.7 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.5 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 0.4 | GO:0004558 | alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.7 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.0 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 1.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.6 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.0 | 0.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 0.5 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.4 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 0.3 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |