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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for DMC1

Z-value: 0.71

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_389662910.786.6e-02Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_8803128 0.71 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr14_+_21492331 0.51 ENST00000533984.1
ENST00000532213.2
AL161668.5
AL161668.5
chr8_+_67104940 0.39 ENST00000517689.1
LINC00967
long intergenic non-protein coding RNA 967
chr19_+_1041187 0.37 ENST00000531467.1
ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr16_-_30122717 0.33 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr12_-_120805872 0.31 ENST00000546985.1
MSI1
musashi RNA-binding protein 1
chr4_-_76944621 0.30 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr14_+_74318611 0.28 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr1_+_1222489 0.22 ENST00000379099.3
SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chrX_-_134305322 0.22 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr6_+_46661575 0.20 ENST00000450697.1
TDRD6
tudor domain containing 6
chr10_+_62538248 0.18 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr14_+_74318513 0.18 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr10_-_74856608 0.18 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr14_+_21525981 0.18 ENST00000308227.2
RNASE8
ribonuclease, RNase A family, 8
chr14_-_21491477 0.17 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr2_-_61244550 0.17 ENST00000421319.1
PUS10
pseudouridylate synthase 10
chr2_+_48667983 0.17 ENST00000449090.2
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr11_-_85779971 0.16 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_75788038 0.16 ENST00000393913.3
ENST00000410113.1
EVA1A
eva-1 homolog A (C. elegans)
chr3_+_9944303 0.16 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr10_+_62538089 0.16 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr14_-_36536396 0.16 ENST00000546376.1
RP11-116N8.4
RP11-116N8.4
chr19_+_11466062 0.15 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr2_-_61244308 0.14 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr4_+_2800722 0.14 ENST00000508385.1
SH3BP2
SH3-domain binding protein 2
chr11_-_85780086 0.14 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_+_148457585 0.14 ENST00000402260.1
AGTR1
angiotensin II receptor, type 1
chr11_-_73720276 0.14 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr17_+_74075263 0.14 ENST00000334586.5
ENST00000392503.2
ZACN
zinc activated ligand-gated ion channel
chr7_-_22539771 0.14 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr21_-_46348694 0.13 ENST00000355153.4
ENST00000397850.2
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr3_-_156840776 0.13 ENST00000471357.1
LINC00880
long intergenic non-protein coding RNA 880
chr2_+_48667898 0.13 ENST00000281394.4
ENST00000294952.8
PPP1R21
protein phosphatase 1, regulatory subunit 21
chr2_+_136343904 0.12 ENST00000436436.1
R3HDM1
R3H domain containing 1
chrX_+_105855160 0.12 ENST00000372544.2
ENST00000372548.4
CXorf57
chromosome X open reading frame 57
chr2_+_219247021 0.11 ENST00000539932.1
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr21_-_35281399 0.11 ENST00000418933.1
ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr2_-_31637560 0.09 ENST00000379416.3
XDH
xanthine dehydrogenase
chr7_+_47694842 0.09 ENST00000408988.2
C7orf65
chromosome 7 open reading frame 65
chrX_-_63450480 0.09 ENST00000362002.2
ASB12
ankyrin repeat and SOCS box containing 12
chr2_+_136343943 0.09 ENST00000409606.1
R3HDM1
R3H domain containing 1
chr2_+_233497931 0.09 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr2_-_18741882 0.09 ENST00000381249.3
RDH14
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr2_-_197675000 0.09 ENST00000342506.2
C2orf66
chromosome 2 open reading frame 66
chr14_-_21492113 0.09 ENST00000554094.1
NDRG2
NDRG family member 2
chr2_+_136343820 0.09 ENST00000410054.1
R3HDM1
R3H domain containing 1
chr3_+_9944492 0.08 ENST00000383814.3
ENST00000454190.2
ENST00000454992.1
IL17RE
interleukin 17 receptor E
chr3_-_141747459 0.08 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_+_101546827 0.08 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr19_-_42947121 0.08 ENST00000601181.1
CXCL17
chemokine (C-X-C motif) ligand 17
chr11_+_101785727 0.08 ENST00000263468.8
KIAA1377
KIAA1377
chr19_-_3600549 0.07 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr17_+_77018896 0.07 ENST00000578229.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr3_-_141747950 0.06 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_-_49103235 0.06 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr17_+_57297807 0.06 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chr1_-_866445 0.06 ENST00000598827.1
AL645608.1
Uncharacterized protein
chr17_+_77019030 0.06 ENST00000580454.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_-_150067696 0.06 ENST00000340413.2
ENST00000367403.3
NUP43
nucleoporin 43kDa
chr10_-_98031310 0.05 ENST00000427367.2
ENST00000413476.2
BLNK
B-cell linker
chr3_+_9834758 0.04 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4
ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr6_+_26383404 0.04 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr2_-_190044480 0.04 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr2_+_120187465 0.04 ENST00000409826.1
ENST00000417645.1
TMEM37
transmembrane protein 37
chr1_-_47131521 0.04 ENST00000542495.1
ENST00000532925.1
ATPAF1
ATP synthase mitochondrial F1 complex assembly factor 1
chr1_-_111061797 0.03 ENST00000369771.2
KCNA10
potassium voltage-gated channel, shaker-related subfamily, member 10
chr2_-_21022818 0.03 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
C2orf43
chromosome 2 open reading frame 43
chr12_-_50677255 0.03 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr11_+_71846764 0.03 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr10_-_98031265 0.03 ENST00000224337.5
ENST00000371176.2
BLNK
B-cell linker
chr11_+_71846748 0.03 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr18_+_11857439 0.03 ENST00000602628.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr6_+_88054530 0.02 ENST00000388923.4
C6orf163
chromosome 6 open reading frame 163
chr6_-_150067632 0.02 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
NUP43
nucleoporin 43kDa
chr3_-_99569821 0.02 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr21_-_46348626 0.02 ENST00000517563.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_+_4846101 0.01 ENST00000576965.1
RNF167
ring finger protein 167
chr1_+_18958008 0.01 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr1_-_190446759 0.00 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1901076 positive regulation of engulfment of apoptotic cell(GO:1901076)
0.0 0.3 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.2 GO:0061760 antifungal innate immune response(GO:0061760)
0.0 0.3 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.1 GO:0046110 xanthine metabolic process(GO:0046110)
0.0 0.1 GO:0002309 T cell proliferation involved in immune response(GO:0002309) L-arginine import(GO:0043091) divalent metal ion export(GO:0070839) arginine import(GO:0090467)
0.0 0.1 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.7 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.2 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.3 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.5 GO:0047522 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.2 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.0 0.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 0.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0043546 molybdopterin cofactor binding(GO:0043546)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis