Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for DLX4_HOXD8
Z-value: 1.79
Motif logo
Transcription factors associated with DLX4_HOXD8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DLX4 | hg19_v2_chr17_+_48046538_48046575 | -0.48 | 3.4e-01 | Click! |
| HOXD8 | hg19_v2_chr2_+_176994408_176994641 | -0.28 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_91152303 Show fit | 6.65 |
ENST00000371804.3
|
interferon-induced protein with tetratricopeptide repeats 1 |
|
| chr1_-_27998689 Show fit | 6.59 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr12_+_113354341 Show fit | 3.15 |
ENST00000553152.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chrM_+_10464 Show fit | 3.12 |
ENST00000361335.1
|
mitochondrially encoded NADH dehydrogenase 4L |
|
| chr16_-_66864806 Show fit | 2.37 |
ENST00000566336.1
ENST00000394074.2 ENST00000563185.2 ENST00000359087.4 ENST00000379463.2 ENST00000565535.1 ENST00000290810.3 |
NEDD8 activating enzyme E1 subunit 1 |
|
| chr4_+_9446156 Show fit | 2.02 |
ENST00000334879.1
|
defensin, beta 131 |
|
| chrM_+_8366 Show fit | 1.98 |
ENST00000361851.1
|
mitochondrially encoded ATP synthase 8 |
|
| chr2_+_161993465 Show fit | 1.98 |
ENST00000457476.1
|
TRAF family member-associated NFKB activator |
|
| chr7_-_81635106 Show fit | 1.89 |
ENST00000443883.1
|
calcium channel, voltage-dependent, alpha 2/delta subunit 1 |
|
| chr12_+_113344755 Show fit | 1.77 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX4_HOXD8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 6.7 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.6 | 6.6 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.1 | 6.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 6.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.7 | 5.5 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 3.1 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.2 | 2.8 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.2 | 2.4 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 2.4 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 2.3 | GO:0000338 | protein deneddylation(GO:0000338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 5.7 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 3.4 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.0 | 3.3 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 3.0 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.1 | 1.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.7 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 1.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 1.6 | GO:0030126 | COPI vesicle coat(GO:0030126) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.5 | 5.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 5.5 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.1 | 3.7 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.9 | 2.7 | GO:0019781 | NEDD8 activating enzyme activity(GO:0019781) |
| 0.0 | 2.7 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.1 | 2.4 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.4 | 2.2 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.1 | 2.2 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 2.0 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.9 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.9 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 6.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 2.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 2.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 2.2 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.1 | 1.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.8 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.0 | 1.7 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.1 | 1.6 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |