ISMARA results: CXXC1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CXXC1

Z-value: 2.67

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Transcription factors associated with CXXC1

Gene Symbol	Gene ID	Gene Info
CXXC1 Ensembl NCBI GeneCards UniProt	ENSG00000154832.10	CXXC finger protein 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CXXC1	hg19_v2_chr18_-_47813940_47814021	-0.95	4.4e-03	Click!

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_+_173991633 Show fit	2.88	ENST00000424181.1	RP11-160H22.3 Ensembl NCBI GeneCards UniProt Show fit	RP11-160H22.3
chr2_+_183989157 Show fit	2.09	ENST00000541912.1	NUP35 Ensembl NCBI GeneCards UniProt Show fit	nucleoporin 35kDa
chr2_+_201390843 Show fit	1.84	ENST00000357799.4 ENST00000409203.3	SGOL2 Ensembl NCBI GeneCards UniProt Show fit	shugoshin-like 2 (S. pombe)
chr1_+_40723779 Show fit	1.63	ENST00000372759.3	ZMPSTE24 Ensembl NCBI GeneCards UniProt Show fit	zinc metallopeptidase STE24
chr5_+_82373317 Show fit	1.63	ENST00000282268.3 ENST00000338635.6	XRCC4 Ensembl NCBI GeneCards UniProt Show fit	X-ray repair complementing defective repair in Chinese hamster cells 4
chr3_-_146262293 Show fit	1.57	ENST00000448205.1	PLSCR1 Ensembl NCBI GeneCards UniProt Show fit	phospholipid scramblase 1
chr9_+_79792269 Show fit	1.56	ENST00000376634.4 ENST00000376636.3 ENST00000360280.3	VPS13A Ensembl NCBI GeneCards UniProt Show fit	vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr13_-_33112956 Show fit	1.52	ENST00000505213.1	N4BP2L2 Ensembl NCBI GeneCards UniProt Show fit	NEDD4 binding protein 2-like 2
chr4_+_25378826 Show fit	1.52	ENST00000315368.3	ANAPC4 Ensembl NCBI GeneCards UniProt Show fit	anaphase promoting complex subunit 4
chr13_-_33112823 Show fit	1.48	ENST00000504114.1	N4BP2L2 Ensembl NCBI GeneCards UniProt Show fit	NEDD4 binding protein 2-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	6.5	GO:2000371	regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.5	4.7	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.2	4.1	GO:0051382	kinetochore assembly(GO:0051382)
0.1	3.5	GO:0006999	nuclear pore organization(GO:0006999)
0.1	3.2	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	3.0	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	2.8	GO:0035176	social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1	2.5	GO:0071285	cellular response to lithium ion(GO:0071285)
0.1	2.4	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.1	2.2	GO:0043968	histone H2A acetylation(GO:0043968)

Showing 1 to 10 of 404 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	3.9	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	3.6	GO:0016580	Sin3 complex(GO:0016580)
0.2	3.4	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	3.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	3.0	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	2.9	GO:0031045	dense core granule(GO:0031045)
0.0	2.8	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.4	2.5	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	2.5	GO:0036064	ciliary basal body(GO:0036064)

Showing 1 to 10 of 165 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.5	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	4.3	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	3.8	GO:0061659	ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	3.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	3.5	GO:0047485	protein N-terminus binding(GO:0047485)
0.1	3.4	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.1	3.4	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	3.0	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	2.8	GO:0042169	SH2 domain binding(GO:0042169)
0.1	2.3	GO:0008536	Ran GTPase binding(GO:0008536)

Showing 1 to 10 of 278 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.0	3.4	PID FANCONI PATHWAY	Fanconi anemia pathway
0.0	3.2	PID RAC1 PATHWAY	RAC1 signaling pathway
0.1	3.0	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	2.6	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	2.4	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	2.0	PID BMP PATHWAY	BMP receptor signaling
0.1	1.5	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.1	1.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.3	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.1	7.1	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	5.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	4.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.1	2.6	REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK	Genes involved in Energy dependent regulation of mTOR by LKB1-AMPK
0.1	2.6	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	2.5	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1	2.1	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	2.1	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	2.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 86 entries

Results for CXXC1

Z-value: 2.67

Motif logo

Transcription factors associated with CXXC1

Activity-expression correlation:

Activity profile of CXXC1 motif

Sorted Z-values of CXXC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CXXC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: