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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB5_CREM_JUNB
Z-value: 1.12
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Transcription factors associated with CREB5_CREM_JUNB
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000146592.12 | cAMP responsive element binding protein 5 | |
| ENSG00000095794.15 | cAMP responsive element modulator | |
| ENSG00000171223.4 | JunB proto-oncogene, AP-1 transcription factor subunit |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREM | hg19_v2_chr10_+_35464513_35464631 | 0.80 | 5.7e-02 | Click! |
| CREB5 | hg19_v2_chr7_+_28725585_28725608 | -0.56 | 2.5e-01 | Click! |
| JUNB | hg19_v2_chr19_+_12902289_12902310 | -0.29 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_100660833 Show fit | 0.98 |
ENST00000551642.1
ENST00000416321.1 ENST00000550587.1 ENST00000549249.1 |
DEP domain containing 4 |
|
| chr6_+_30749649 Show fit | 0.86 |
ENST00000422944.1
|
HLA complex group 20 (non-protein coding) |
|
| chr4_+_75311019 Show fit | 0.85 |
ENST00000502307.1
|
amphiregulin |
|
| chr1_+_168148273 Show fit | 0.73 |
ENST00000367830.3
|
TIP41, TOR signaling pathway regulator-like (S. cerevisiae) |
|
| chr20_+_5892147 Show fit | 0.72 |
ENST00000455042.1
|
chromogranin B (secretogranin 1) |
|
| chr4_+_75310851 Show fit | 0.72 |
ENST00000395748.3
ENST00000264487.2 |
amphiregulin |
|
| chr20_+_33146510 Show fit | 0.68 |
ENST00000397709.1
|
microtubule-associated protein 1 light chain 3 alpha |
|
| chr16_+_68057179 Show fit | 0.68 |
ENST00000567100.1
ENST00000432752.1 ENST00000569289.1 ENST00000564781.1 |
dihydrouridine synthase 2 |
|
| chr4_+_75480629 Show fit | 0.68 |
ENST00000380846.3
|
amphiregulin B |
|
| chr8_+_40010989 Show fit | 0.66 |
ENST00000315792.3
|
chromosome 8 open reading frame 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB5_CREM_JUNB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | GO:0002943 | tRNA dihydrouridine synthesis(GO:0002943) |
| 0.2 | 1.6 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.2 | 1.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.2 | 1.2 | GO:2000619 | negative regulation of histone H4-K16 acetylation(GO:2000619) |
| 0.1 | 1.1 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.0 | 1.1 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.2 | 0.9 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.0 | 0.9 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.8 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.0 | 0.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 1.3 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 1.2 | GO:0034274 | Atg12-Atg5-Atg16 complex(GO:0034274) |
| 0.1 | 1.1 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 1.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.9 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 0.8 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 0.8 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.2 | 0.7 | GO:0075341 | host cell PML body(GO:0075341) |
| 0.1 | 0.7 | GO:0005828 | kinetochore microtubule(GO:0005828) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.6 | GO:0017150 | tRNA dihydrouridine synthase activity(GO:0017150) |
| 0.0 | 1.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 1.2 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.2 | 1.2 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.1 | 1.1 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.0 | 1.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.0 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.8 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.7 | GO:0005112 | Notch binding(GO:0005112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.2 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 0.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 1.2 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.0 | 1.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 1.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.7 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |