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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CREB1
Z-value: 0.93
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Transcription factors associated with CREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CREB1 | hg19_v2_chr2_+_208414985_208415079 | 0.56 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.2 | 1.2 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.0 | 0.9 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.8 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 0.7 | GO:0042791 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.0 | 0.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.2 | 0.6 | GO:0048075 | positive regulation of eye pigmentation(GO:0048075) |
| 0.1 | 0.6 | GO:0070843 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.1 | 0.6 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.2 | 0.5 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.7 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.1 | 0.7 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.1 | 0.6 | GO:0031085 | BLOC-3 complex(GO:0031085) |
| 0.1 | 0.6 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.6 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.6 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 0.5 | GO:0097361 | CIA complex(GO:0097361) |
| 0.0 | 0.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0009378 | four-way junction helicase activity(GO:0009378) |
| 0.0 | 1.7 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.8 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 0.0 | 0.8 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.2 | 0.7 | GO:0015039 | ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731) |
| 0.1 | 0.6 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 0.6 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.2 | 0.5 | GO:0034353 | RNA pyrophosphohydrolase activity(GO:0034353) |
| 0.2 | 0.5 | GO:0070364 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 0.1 | 0.5 | GO:0034602 | oxoglutarate dehydrogenase (NAD+) activity(GO:0034602) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.6 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| 0.0 | 0.4 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 0.3 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.0 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |