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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CLOCK
Z-value: 1.25
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Transcription factors associated with CLOCK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CLOCK | hg19_v2_chr4_-_56412713_56412799 | 0.27 | 6.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CLOCK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.1 | 1.4 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.0 | 1.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 1.2 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
| 0.1 | 1.2 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.1 | 1.0 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 1.0 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.0 | 1.0 | GO:0008655 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) regulation of transmission of nerve impulse(GO:0051969) |
| 0.1 | 0.9 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.9 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.2 | 1.0 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 0.9 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.9 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.7 | GO:0097470 | ribbon synapse(GO:0097470) |
| 0.1 | 0.6 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.6 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.0 | 0.5 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 0.0 | 0.5 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.0 | 0.5 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.1 | 1.0 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.1 | 1.0 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
| 0.0 | 1.0 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.1 | 0.9 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 0.9 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.9 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.3 | 0.8 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.0 | 0.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.4 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 1.4 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 1.2 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 1.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.9 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.6 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.6 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |