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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPE_CEBPD
Z-value: 1.87
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Transcription factors associated with CEBPE_CEBPD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPD | hg19_v2_chr8_-_48651648_48651648 | -0.37 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_86230315 Show fit | 2.39 |
ENST00000361228.3
|
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 |
|
| chr3_-_148939598 Show fit | 2.31 |
ENST00000455472.3
|
ceruloplasmin (ferroxidase) |
|
| chr11_+_18287801 Show fit | 2.25 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr6_+_31895467 Show fit | 2.15 |
ENST00000556679.1
ENST00000456570.1 |
complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
|
| chr3_-_148939835 Show fit | 1.94 |
ENST00000264613.6
|
ceruloplasmin (ferroxidase) |
|
| chr1_-_186649543 Show fit | 1.89 |
ENST00000367468.5
|
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
|
| chr11_+_18287721 Show fit | 1.83 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr7_-_83824449 Show fit | 1.73 |
ENST00000420047.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chr7_+_22766766 Show fit | 1.66 |
ENST00000426291.1
ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1 |
interleukin 6 (interferon, beta 2) |
|
| chr6_+_31895480 Show fit | 1.64 |
ENST00000418949.2
ENST00000383177.3 ENST00000477310.1 |
complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPE_CEBPD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.3 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 0.1 | 4.2 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.2 | 3.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.9 | 3.6 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.0 | 2.7 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.7 | 2.6 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.2 | 2.3 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822) |
| 0.0 | 2.1 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.3 | 2.0 | GO:1903786 | mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788) |
| 0.6 | 1.9 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 3.4 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 2.4 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 2.1 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.0 | 2.0 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 2.0 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 1.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.3 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 1.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 1.2 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 4.4 | GO:0001848 | complement binding(GO:0001848) |
| 0.5 | 4.3 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 3.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 2.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 2.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 2.3 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.4 | 1.9 | GO:0050473 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.0 | 1.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 4.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 3.6 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 3.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 2.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.9 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 1.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 4.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 3.6 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 3.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 3.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 2.5 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.5 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 2.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 1.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |