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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for CEBPB
Z-value: 1.07
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Transcription factors associated with CEBPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPB | hg19_v2_chr20_+_48807351_48807384 | 0.66 | 1.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CEBPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0090214 | spongiotrophoblast layer developmental growth(GO:0090214) |
| 0.1 | 0.9 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.1 | 0.7 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 0.1 | 0.7 | GO:0046878 | positive regulation of saliva secretion(GO:0046878) |
| 0.1 | 0.7 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.0 | 0.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.6 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.1 | 0.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 0.6 | GO:0001878 | response to yeast(GO:0001878) |
| 0.1 | 0.6 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.7 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.6 | GO:0043203 | axon hillock(GO:0043203) |
| 0.1 | 0.4 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 0.4 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 0.3 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.2 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 0.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 0.1 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.0 | 0.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.7 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.2 | 0.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 0.6 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.6 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 0.4 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.1 | 0.4 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 0.0 | 0.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.4 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.8 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.5 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.4 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.4 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 0.2 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |