ISMARA results: CEBPA

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for CEBPA

Z-value: 1.97

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Transcription factors associated with CEBPA

Gene Symbol	Gene ID	Gene Info
CEBPA Ensembl NCBI GeneCards UniProt	ENSG00000245848.2	CCAAT enhancer binding protein alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
CEBPA	hg19_v2_chr19_-_33793430_33793470	-0.45	3.7e-01	Click!

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_72058130 Show fit	2.84	ENST00000547843.1	THAP2 Ensembl NCBI GeneCards UniProt Show fit	THAP domain containing, apoptosis associated protein 2
chr4_-_155533787 Show fit	2.77	ENST00000407946.1 ENST00000405164.1 ENST00000336098.3 ENST00000393846.2 ENST00000404648.3 ENST00000443553.1	FGG Ensembl NCBI GeneCards UniProt Show fit	fibrinogen gamma chain
chr3_-_129375556 Show fit	2.67	ENST00000510323.1	TMCC1 Ensembl NCBI GeneCards UniProt Show fit	transmembrane and coiled-coil domain family 1
chr20_-_43883197 Show fit	2.55	ENST00000338380.2	SLPI Ensembl NCBI GeneCards UniProt Show fit	secretory leukocyte peptidase inhibitor
chr18_-_61329118 Show fit	2.55	ENST00000332821.8 ENST00000283752.5	SERPINB3 Ensembl NCBI GeneCards UniProt Show fit	serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr1_+_196621002 Show fit	2.46	ENST00000367429.4 ENST00000439155.2	CFH Ensembl NCBI GeneCards UniProt Show fit	complement factor H
chr6_+_31895467 Show fit	2.44	ENST00000556679.1 ENST00000456570.1	CFB Ensembl NCBI GeneCards UniProt Show fit CFB Ensembl NCBI GeneCards UniProt Show fit	complement factor B Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B
chr1_+_196621156 Show fit	2.14	ENST00000359637.2	CFH Ensembl NCBI GeneCards UniProt Show fit	complement factor H
chr9_+_130911723 Show fit	2.03	ENST00000277480.2 ENST00000373013.2 ENST00000540948.1	LCN2 Ensembl NCBI GeneCards UniProt Show fit	lipocalin 2
chr6_+_31895480 Show fit	1.93	ENST00000418949.2 ENST00000383177.3 ENST00000477310.1	C2 Ensembl NCBI GeneCards UniProt Show fit CFB Ensembl NCBI GeneCards UniProt Show fit	complement component 2 Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	10.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	3.2	GO:0031639	plasminogen activation(GO:0031639)
0.6	3.1	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0	2.9	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.1	2.8	GO:0006825	copper ion transport(GO:0006825)
0.1	2.8	GO:0050716	positive regulation of interleukin-1 secretion(GO:0050716)
0.1	2.6	GO:0019731	antibacterial humoral response(GO:0019731)
0.6	2.5	GO:0035425	autocrine signaling(GO:0035425)
0.0	2.4	GO:0002292	T cell differentiation involved in immune response(GO:0002292)
0.0	2.2	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)

Showing 1 to 10 of 157 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.9	GO:0072562	blood microparticle(GO:0072562)
0.0	4.1	GO:0035580	specific granule lumen(GO:0035580)
0.0	2.9	GO:0035578	azurophil granule lumen(GO:0035578)
0.2	2.8	GO:0005577	fibrinogen complex(GO:0005577)
0.1	2.8	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	2.6	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	1.6	GO:0043203	axon hillock(GO:0043203)
0.0	1.5	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.1	1.4	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	1.1	GO:0008180	COP9 signalosome(GO:0008180)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	5.2	GO:0001848	complement binding(GO:0001848)
0.0	4.7	GO:0030246	carbohydrate binding(GO:0030246)
0.2	4.6	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	4.1	GO:0005506	iron ion binding(GO:0005506)
0.1	3.0	GO:0042056	chemoattractant activity(GO:0042056)
0.4	2.8	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.9	GO:0005501	retinoid binding(GO:0005501)
0.2	1.7	GO:0030614	oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.0	1.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 111 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	4.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	4.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	3.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	2.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	2.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	1.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.1	1.7	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	1.5	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	1.5	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	12.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	3.0	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	2.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	2.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	1.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	1.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	1.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix

Showing 1 to 10 of 32 entries

Results for CEBPA

Z-value: 1.97

Motif logo

Transcription factors associated with CEBPA

Activity-expression correlation:

Activity profile of CEBPA motif

Sorted Z-values of CEBPA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of CEBPA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: