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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for BRCA1

Z-value: 0.35

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1 DNA repair associated

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_412773480.582.3e-01Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_152118276 0.25 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr19_-_6057282 0.19 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr3_-_176914191 0.16 ENST00000437738.1
ENST00000424913.1
ENST00000443315.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr19_+_46000479 0.14 ENST00000456399.2
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr8_-_72459885 0.13 ENST00000523987.1
RP11-1102P16.1
Uncharacterized protein
chr11_-_119234876 0.11 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr4_+_619347 0.10 ENST00000255622.6
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr4_+_619386 0.10 ENST00000496514.1
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr8_-_16859690 0.10 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr19_-_48389651 0.09 ENST00000222002.3
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr3_+_184056614 0.09 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr3_-_27410847 0.08 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr8_+_97773202 0.08 ENST00000519484.1
CPQ
carboxypeptidase Q
chr14_+_32030582 0.08 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr19_-_40324767 0.07 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr4_-_48782259 0.07 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRYL
FRY-like
chr19_+_55888186 0.07 ENST00000291934.3
TMEM190
transmembrane protein 190
chr20_+_9049682 0.07 ENST00000334005.3
ENST00000378473.3
PLCB4
phospholipase C, beta 4
chr10_-_69597828 0.07 ENST00000339758.7
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr10_-_95209 0.06 ENST00000332708.5
ENST00000309812.4
TUBB8
tubulin, beta 8 class VIII
chr12_-_49449107 0.06 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr8_-_81083341 0.06 ENST00000519303.2
TPD52
tumor protein D52
chr8_-_116681123 0.06 ENST00000519674.1
TRPS1
trichorhinophalangeal syndrome I
chr10_+_74653330 0.05 ENST00000334011.5
OIT3
oncoprotein induced transcript 3
chr17_+_21730180 0.05 ENST00000584398.1
UBBP4
ubiquitin B pseudogene 4
chr8_+_97773457 0.05 ENST00000521142.1
CPQ
carboxypeptidase Q
chr10_-_95504 0.05 ENST00000447903.2
TUBB8
tubulin, beta 8 class VIII
chr17_-_60142609 0.05 ENST00000397786.2
MED13
mediator complex subunit 13
chr5_-_68664989 0.05 ENST00000508954.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr14_+_103058948 0.05 ENST00000262241.6
RCOR1
REST corepressor 1
chr10_-_69597810 0.05 ENST00000483798.2
DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr19_+_45971246 0.04 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr10_-_102289611 0.04 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NDUFB8
SEC31B
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr12_+_122880045 0.04 ENST00000539034.1
ENST00000535976.1
RP11-450K4.1
RP11-450K4.1
chr10_+_122610853 0.04 ENST00000604585.1
WDR11
WD repeat domain 11
chr10_+_122610687 0.04 ENST00000263461.6
WDR11
WD repeat domain 11
chr7_-_23510086 0.04 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr10_-_61900762 0.04 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_196521903 0.03 ENST00000541054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr5_+_139027877 0.03 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr16_-_790982 0.03 ENST00000301694.5
ENST00000251588.2
NARFL
nuclear prelamin A recognition factor-like
chr12_-_122879969 0.03 ENST00000540304.1
CLIP1
CAP-GLY domain containing linker protein 1
chr7_+_99717230 0.03 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chr17_+_36584662 0.03 ENST00000431231.2
ENST00000437668.3
ARHGAP23
Rho GTPase activating protein 23
chr5_+_140186647 0.03 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chrX_-_70288234 0.03 ENST00000276105.3
ENST00000374274.3
SNX12
sorting nexin 12
chr11_+_47291645 0.03 ENST00000395336.3
ENST00000402192.2
MADD
MAP-kinase activating death domain
chr8_+_22022800 0.03 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr16_-_790887 0.03 ENST00000540986.1
NARFL
nuclear prelamin A recognition factor-like
chr19_+_46850320 0.02 ENST00000391919.1
PPP5C
protein phosphatase 5, catalytic subunit
chr3_+_193853927 0.02 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_+_10271674 0.02 ENST00000377086.1
KIF1B
kinesin family member 1B
chr6_+_42981922 0.02 ENST00000326974.4
ENST00000244670.8
KLHDC3
kelch domain containing 3
chr19_+_46850251 0.02 ENST00000012443.4
PPP5C
protein phosphatase 5, catalytic subunit
chr15_-_88799948 0.02 ENST00000394480.2
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_6010263 0.02 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
chr5_-_68665469 0.02 ENST00000217893.5
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr17_-_56296580 0.02 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
MKS1
Meckel syndrome, type 1
chr1_+_70687079 0.02 ENST00000395136.2
SRSF11
serine/arginine-rich splicing factor 11
chr13_-_99910673 0.02 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr2_-_158182105 0.02 ENST00000409925.1
ERMN
ermin, ERM-like protein
chr12_-_95510743 0.02 ENST00000551521.1
FGD6
FYVE, RhoGEF and PH domain containing 6
chr2_-_134326009 0.02 ENST00000409261.1
ENST00000409213.1
NCKAP5
NCK-associated protein 5
chr8_+_37553261 0.02 ENST00000331569.4
ZNF703
zinc finger protein 703
chr2_+_196521458 0.02 ENST00000409086.3
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr6_+_16129308 0.02 ENST00000356840.3
ENST00000349606.4
MYLIP
myosin regulatory light chain interacting protein
chr5_-_124082279 0.02 ENST00000513986.1
ZNF608
zinc finger protein 608
chr2_-_179914760 0.02 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
CCDC141
coiled-coil domain containing 141
chr5_+_145583156 0.02 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr1_-_160232197 0.01 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr8_+_22022653 0.01 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr13_-_99910620 0.01 ENST00000416594.1
GPR18
G protein-coupled receptor 18
chr11_-_71823266 0.01 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr9_-_86593238 0.01 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr1_-_227505289 0.01 ENST00000366765.3
CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr2_+_223725652 0.01 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr6_-_66417107 0.01 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr5_+_140079919 0.01 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr15_+_67430339 0.01 ENST00000439724.3
SMAD3
SMAD family member 3
chr19_-_37663332 0.01 ENST00000392157.2
ZNF585A
zinc finger protein 585A
chr10_+_102295616 0.01 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr1_-_232598163 0.01 ENST00000308942.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr18_-_23671139 0.01 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr11_-_110583912 0.01 ENST00000533353.1
ENST00000527598.1
ARHGAP20
Rho GTPase activating protein 20
chr2_+_61404624 0.01 ENST00000394457.3
AHSA2
AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr8_+_22462532 0.01 ENST00000389279.3
CCAR2
cell cycle and apoptosis regulator 2
chr5_-_68665084 0.01 ENST00000509462.1
TAF9
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chrX_-_10851762 0.01 ENST00000380785.1
ENST00000380787.1
MID1
midline 1 (Opitz/BBB syndrome)
chrX_+_150565038 0.01 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr2_+_98703595 0.01 ENST00000435344.1
VWA3B
von Willebrand factor A domain containing 3B
chr17_+_36908984 0.01 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr12_-_49418407 0.01 ENST00000526209.1
KMT2D
lysine (K)-specific methyltransferase 2D
chr2_-_158182322 0.01 ENST00000420719.2
ENST00000409216.1
ERMN
ermin, ERM-like protein
chr17_-_27230035 0.00 ENST00000378895.4
ENST00000394901.3
DHRS13
dehydrogenase/reductase (SDR family) member 13
chr2_-_171571077 0.00 ENST00000409786.1
AC007405.2
long intergenic non-protein coding RNA 1124
chr6_-_170862322 0.00 ENST00000262193.6
PSMB1
proteasome (prosome, macropain) subunit, beta type, 1
chr11_+_47291193 0.00 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
MADD
MAP-kinase activating death domain
chr14_-_75179774 0.00 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr6_-_42981651 0.00 ENST00000244711.3
MEA1
male-enhanced antigen 1
chrX_-_46187069 0.00 ENST00000446884.1
RP1-30G7.2
RP1-30G7.2
chr6_+_123100620 0.00 ENST00000368444.3
FABP7
fatty acid binding protein 7, brain
chr10_+_28822636 0.00 ENST00000442148.1
ENST00000448193.1
WAC
WW domain containing adaptor with coiled-coil

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.1 GO:0030573 bile acid catabolic process(GO:0030573)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002079 inner acrosomal membrane(GO:0002079)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)