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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for BPTF
Z-value: 1.36
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Transcription factors associated with BPTF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BPTF | hg19_v2_chr17_+_65821780_65821826 | -0.18 | 7.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_26585686 Show fit | 1.01 |
ENST00000505206.1
ENST00000511789.1 |
TBC1 domain family, member 19 |
|
| chr1_+_948803 Show fit | 0.86 |
ENST00000379389.4
|
ISG15 ubiquitin-like modifier |
|
| chr9_-_16705069 Show fit | 0.76 |
ENST00000471301.2
|
basonuclin 2 |
|
| chr4_+_14113592 Show fit | 0.62 |
ENST00000502759.1
ENST00000511200.1 ENST00000512754.1 ENST00000506739.1 |
long intergenic non-protein coding RNA 1085 |
|
| chr4_-_85771168 Show fit | 0.62 |
ENST00000514071.1
|
WD repeat and FYVE domain containing 3 |
|
| chr3_-_182881595 Show fit | 0.57 |
ENST00000476015.1
|
lysosomal-associated membrane protein 3 |
|
| chr14_-_45722360 Show fit | 0.56 |
ENST00000451174.1
|
MIS18 binding protein 1 |
|
| chr14_+_61449197 Show fit | 0.52 |
ENST00000533744.2
|
solute carrier family 38, member 6 |
|
| chr2_-_25451065 Show fit | 0.52 |
ENST00000606328.1
|
RP11-458N5.1 |
|
| chr17_+_57807062 Show fit | 0.51 |
ENST00000587259.1
|
vacuole membrane protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BPTF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.0 | 1.3 | GO:0043486 | histone exchange(GO:0043486) |
| 0.1 | 1.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 1.0 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.2 | 0.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 0.8 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.1 | 0.8 | GO:0031120 | snRNA pseudouridine synthesis(GO:0031120) |
| 0.0 | 0.8 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.2 | 0.7 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 0.7 | GO:0000460 | maturation of 5.8S rRNA(GO:0000460) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0031429 | box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) |
| 0.1 | 0.8 | GO:0000778 | condensed nuclear chromosome kinetochore(GO:0000778) |
| 0.0 | 0.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.2 | 0.6 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.0 | 0.6 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
| 0.0 | 0.6 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 0.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.6 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.5 | GO:0097232 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.0 | 0.5 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 1.0 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.0 | 1.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 0.9 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 0.8 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 0.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 0.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.6 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.6 | GO:0004376 | glycolipid mannosyltransferase activity(GO:0004376) |
| 0.0 | 0.6 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.5 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.2 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.8 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.7 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.7 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.7 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 0.5 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.0 | 0.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.5 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |