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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AR_NR3C2

Z-value: 0.57

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 androgen receptor
NR3C2
ENSG00000151623.10 nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR3C2hg19_v2_chr4_-_149363376_1493634920.325.3e-01Click!
ARhg19_v2_chrX_+_66764375_667644650.108.5e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_26235206 0.70 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr16_-_787771 0.40 ENST00000568545.1
NARFL
nuclear prelamin A recognition factor-like
chr1_+_1846519 0.38 ENST00000378604.3
CALML6
calmodulin-like 6
chr17_+_79071365 0.37 ENST00000576756.1
BAIAP2
BAI1-associated protein 2
chr16_-_787728 0.32 ENST00000567403.1
ENST00000562421.1
NARFL
nuclear prelamin A recognition factor-like
chr5_-_149792295 0.31 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr15_+_31658349 0.26 ENST00000558844.1
KLF13
Kruppel-like factor 13
chr17_+_79031415 0.26 ENST00000572073.1
ENST00000573677.1
BAIAP2
BAI1-associated protein 2
chr19_+_35630344 0.26 ENST00000455515.2
FXYD1
FXYD domain containing ion transport regulator 1
chr5_-_141392538 0.23 ENST00000503794.1
ENST00000510194.1
ENST00000504424.1
ENST00000513454.1
ENST00000458112.2
ENST00000542860.1
ENST00000503229.1
ENST00000500692.2
ENST00000311337.6
ENST00000504139.1
ENST00000505689.1
GNPDA1
glucosamine-6-phosphate deaminase 1
chr11_-_236326 0.23 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
SIRT3
sirtuin 3
chr2_+_238395879 0.23 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
MLPH
melanophilin
chr2_+_102953608 0.22 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr5_+_140186647 0.22 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr3_+_125985620 0.21 ENST00000511512.1
ENST00000512435.1
RP11-71E19.1
RP11-71E19.1
chr17_-_19290117 0.20 ENST00000497081.2
MFAP4
microfibrillar-associated protein 4
chr2_+_238395803 0.20 ENST00000264605.3
MLPH
melanophilin
chr2_-_27435634 0.20 ENST00000430186.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr2_-_27435390 0.19 ENST00000428518.1
SLC5A6
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr17_-_79304150 0.19 ENST00000574093.1
TMEM105
transmembrane protein 105
chr9_-_35563896 0.18 ENST00000399742.2
FAM166B
family with sequence similarity 166, member B
chr12_+_122241928 0.17 ENST00000604567.1
ENST00000542440.1
SETD1B
SET domain containing 1B
chr2_-_242576864 0.16 ENST00000407315.1
THAP4
THAP domain containing 4
chr17_-_19290483 0.16 ENST00000395592.2
ENST00000299610.4
MFAP4
microfibrillar-associated protein 4
chr1_-_1149506 0.15 ENST00000379236.3
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr8_+_9046503 0.14 ENST00000512942.2
RP11-10A14.5
RP11-10A14.5
chr12_-_11002063 0.14 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
PRR4
proline rich 4 (lacrimal)
chr19_+_56187987 0.14 ENST00000411543.2
EPN1
epsin 1
chr1_-_145715565 0.14 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
CD160
CD160 molecule
chr14_+_32414059 0.13 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr15_+_65204075 0.13 ENST00000380230.3
ENST00000357698.3
ENST00000395720.1
ENST00000496660.1
ENST00000319580.8
ANKDD1A
ankyrin repeat and death domain containing 1A
chr1_-_10856694 0.13 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr8_-_145634731 0.13 ENST00000349769.3
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr17_-_3794021 0.13 ENST00000381769.2
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr12_-_106480587 0.13 ENST00000548902.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr3_+_52279737 0.12 ENST00000457351.2
PPM1M
protein phosphatase, Mg2+/Mn2+ dependent, 1M
chr9_+_131683174 0.11 ENST00000372592.3
ENST00000428610.1
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr2_-_74875432 0.11 ENST00000536235.1
ENST00000421985.1
M1AP
meiosis 1 associated protein
chr16_-_4852915 0.11 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr8_-_145634666 0.11 ENST00000531042.1
CPSF1
cleavage and polyadenylation specific factor 1, 160kDa
chr1_-_204119009 0.11 ENST00000444817.1
ETNK2
ethanolamine kinase 2
chr8_-_72756667 0.10 ENST00000325509.4
MSC
musculin
chr5_-_68339648 0.10 ENST00000479830.2
CTC-498J12.1
CTC-498J12.1
chr4_-_8442438 0.10 ENST00000356406.5
ENST00000413009.2
ACOX3
acyl-CoA oxidase 3, pristanoyl
chr12_+_51318513 0.10 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr8_+_38614754 0.10 ENST00000521642.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr16_-_67978016 0.10 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr18_-_48346298 0.10 ENST00000398439.3
MRO
maestro
chr19_+_57874835 0.09 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
TRAPPC2P1
ZNF547
AC003002.4
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr12_-_53575120 0.09 ENST00000542115.1
CSAD
cysteine sulfinic acid decarboxylase
chr12_-_56848426 0.09 ENST00000257979.4
MIP
major intrinsic protein of lens fiber
chr11_-_506739 0.09 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
RNH1
ribonuclease/angiogenin inhibitor 1
chrX_+_2609356 0.09 ENST00000381180.3
ENST00000449611.1
CD99
CD99 molecule
chr19_+_54704610 0.09 ENST00000302907.4
RPS9
ribosomal protein S9
chr19_-_14117074 0.09 ENST00000588885.1
ENST00000254325.4
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr8_-_110615669 0.09 ENST00000533394.1
SYBU
syntabulin (syntaxin-interacting)
chr8_-_23021533 0.08 ENST00000312584.3
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr14_-_21493884 0.08 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr2_-_73298802 0.08 ENST00000411783.1
ENST00000410065.1
ENST00000442582.1
ENST00000272433.2
SFXN5
sideroflexin 5
chr19_+_35630926 0.08 ENST00000588081.1
ENST00000589121.1
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_166702601 0.08 ENST00000428888.1
AC009495.4
AC009495.4
chr7_+_74379083 0.08 ENST00000361825.7
GATSL1
GATS protein-like 1
chr12_+_53443963 0.08 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr10_+_696000 0.08 ENST00000381489.5
PRR26
proline rich 26
chr4_+_87928140 0.07 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr2_-_75788424 0.07 ENST00000410071.1
EVA1A
eva-1 homolog A (C. elegans)
chr2_+_242577027 0.07 ENST00000402096.1
ENST00000404914.3
ATG4B
autophagy related 4B, cysteine peptidase
chrX_+_2609317 0.06 ENST00000381187.3
ENST00000381184.1
CD99
CD99 molecule
chr1_-_27693349 0.06 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr12_+_125549925 0.06 ENST00000316519.6
AACS
acetoacetyl-CoA synthetase
chr4_-_69817481 0.06 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr10_+_695888 0.06 ENST00000441152.2
PRR26
proline rich 26
chr4_+_186347388 0.06 ENST00000511138.1
ENST00000511581.1
C4orf47
chromosome 4 open reading frame 47
chr19_-_8408139 0.06 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
KANK3
KN motif and ankyrin repeat domains 3
chr12_+_53443680 0.06 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr17_+_38333263 0.06 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr16_+_67207838 0.06 ENST00000566871.1
ENST00000268605.7
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr6_-_111927062 0.06 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr16_+_67207872 0.05 ENST00000563258.1
ENST00000568146.1
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
chr22_+_24030321 0.05 ENST00000401461.1
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr12_+_56615761 0.05 ENST00000447747.1
ENST00000399713.2
NABP2
nucleic acid binding protein 2
chr1_-_24469602 0.05 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr8_-_49833978 0.05 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr16_-_4852616 0.05 ENST00000591392.1
ENST00000587711.1
ROGDI
rogdi homolog (Drosophila)
chr8_-_21669826 0.05 ENST00000517328.1
GFRA2
GDNF family receptor alpha 2
chr17_+_38498594 0.05 ENST00000394081.3
RARA
retinoic acid receptor, alpha
chr5_-_173043591 0.05 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr2_-_231825668 0.05 ENST00000392039.2
GPR55
G protein-coupled receptor 55
chrX_+_2609207 0.04 ENST00000381192.3
CD99
CD99 molecule
chr17_+_46918925 0.04 ENST00000502761.1
CALCOCO2
calcium binding and coiled-coil domain 2
chr17_-_14140166 0.04 ENST00000420162.2
ENST00000431716.2
CDRT15
CMT1A duplicated region transcript 15
chr22_+_38054721 0.04 ENST00000215904.6
PDXP
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr10_+_48359344 0.04 ENST00000412534.1
ENST00000444585.1
ZNF488
zinc finger protein 488
chr1_+_162335197 0.04 ENST00000431696.1
RP11-565P22.6
Uncharacterized protein
chr11_-_75380165 0.04 ENST00000304771.3
MAP6
microtubule-associated protein 6
chr12_+_1099675 0.04 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr16_-_66584059 0.04 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chr11_+_236540 0.04 ENST00000532097.1
PSMD13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr18_+_56530136 0.03 ENST00000591083.1
ZNF532
zinc finger protein 532
chr12_+_66582919 0.03 ENST00000545837.1
ENST00000457197.2
IRAK3
interleukin-1 receptor-associated kinase 3
chr22_+_19939026 0.03 ENST00000406520.3
COMT
catechol-O-methyltransferase
chr1_+_76262552 0.03 ENST00000263187.3
MSH4
mutS homolog 4
chr12_+_125549973 0.03 ENST00000536752.1
ENST00000261686.6
AACS
acetoacetyl-CoA synthetase
chr16_+_56642489 0.03 ENST00000561491.1
MT2A
metallothionein 2A
chr6_+_123317116 0.03 ENST00000275162.5
CLVS2
clavesin 2
chr4_+_37892682 0.03 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr9_-_106087316 0.03 ENST00000411575.1
RP11-341A22.2
RP11-341A22.2
chr1_-_159832438 0.02 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr11_-_114271139 0.02 ENST00000325636.4
C11orf71
chromosome 11 open reading frame 71
chr18_-_48346415 0.02 ENST00000431965.2
ENST00000436348.2
MRO
maestro
chr4_+_8442496 0.02 ENST00000389737.4
ENST00000504134.1
TRMT44
tRNA methyltransferase 44 homolog (S. cerevisiae)
chr19_+_1261106 0.02 ENST00000588411.1
CIRBP
cold inducible RNA binding protein
chr10_-_87551311 0.02 ENST00000536331.1
GRID1
glutamate receptor, ionotropic, delta 1
chr2_-_109605663 0.02 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
EDAR
ectodysplasin A receptor
chr19_-_45657028 0.02 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr2_+_242577097 0.02 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
ATG4B
autophagy related 4B, cysteine peptidase
chr18_-_48346130 0.02 ENST00000592966.1
MRO
maestro
chr16_+_56672571 0.02 ENST00000290705.8
MT1A
metallothionein 1A
chr8_-_49834299 0.02 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr4_-_135122903 0.02 ENST00000421491.3
ENST00000529122.2
PABPC4L
poly(A) binding protein, cytoplasmic 4-like
chr19_-_42916499 0.02 ENST00000601189.1
ENST00000599211.1
LIPE
lipase, hormone-sensitive
chr19_+_58570605 0.02 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
ZNF135
zinc finger protein 135
chr13_+_113777105 0.02 ENST00000409306.1
ENST00000375551.3
ENST00000375559.3
F10
coagulation factor X
chr19_+_35630628 0.02 ENST00000588715.1
ENST00000588607.1
FXYD1
FXYD domain containing ion transport regulator 1
chr2_-_37551846 0.01 ENST00000443187.1
PRKD3
protein kinase D3
chrX_+_153029633 0.01 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr19_-_14945933 0.01 ENST00000322301.3
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr3_+_13521665 0.01 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
HDAC11
histone deacetylase 11
chr17_-_65242063 0.01 ENST00000581159.1
HELZ
helicase with zinc finger
chr2_+_27435734 0.01 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr1_+_93811438 0.01 ENST00000370272.4
ENST00000370267.1
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr16_+_56642041 0.01 ENST00000245185.5
MT2A
metallothionein 2A
chr7_-_4877677 0.01 ENST00000538469.1
RADIL
Ras association and DIL domains
chrX_-_117119243 0.01 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chrX_-_80377118 0.01 ENST00000373250.3
HMGN5
high mobility group nucleosome binding domain 5
chr20_+_15177480 0.00 ENST00000402914.1
MACROD2
MACRO domain containing 2
chr3_-_24207039 0.00 ENST00000280696.5
THRB
thyroid hormone receptor, beta
chr15_-_28344439 0.00 ENST00000431101.1
ENST00000445578.1
ENST00000353809.5
ENST00000382996.2
ENST00000354638.3
OCA2
oculocutaneous albinism II

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.2 GO:0006043 glucosamine catabolic process(GO:0006043)
0.1 0.6 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.1 0.4 GO:0015878 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887)
0.1 0.3 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 0.7 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.4 GO:0010732 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 0.1 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.0 0.1 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.0 0.2 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.4 GO:0071493 elastic fiber assembly(GO:0048251) cellular response to UV-B(GO:0071493)
0.0 0.4 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:0042412 taurine biosynthetic process(GO:0042412)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 0.1 GO:0007060 male meiosis chromosome segregation(GO:0007060)
0.0 0.1 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.2 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.1 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0 0.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097361 CIA complex(GO:0097361)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.2 GO:0002113 interleukin-33 binding(GO:0002113)
0.0 0.4 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.1 GO:0035877 death effector domain binding(GO:0035877)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism