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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for AHR_ARNT2
Z-value: 1.14
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Transcription factors associated with AHR_ARNT2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT2 | hg19_v2_chr15_+_80733570_80733659 | -0.47 | 3.5e-01 | Click! |
| AHR | hg19_v2_chr7_+_17338239_17338262 | 0.00 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_64970427 Show fit | 0.83 |
ENST00000553583.1
|
zinc finger and BTB domain containing 1 |
|
| chr22_-_39548511 Show fit | 0.75 |
ENST00000434260.1
|
chromobox homolog 7 |
|
| chr17_-_8059638 Show fit | 0.67 |
ENST00000584202.1
ENST00000354903.5 ENST00000577253.1 |
period circadian clock 1 |
|
| chr1_-_228353112 Show fit | 0.67 |
ENST00000366713.1
|
IBA57 antisense RNA 1 (head to head) |
|
| chr14_+_64970662 Show fit | 0.63 |
ENST00000556965.1
ENST00000554015.1 |
zinc finger and BTB domain containing 1 |
|
| chr22_-_39548443 Show fit | 0.63 |
ENST00000401405.3
|
chromobox homolog 7 |
|
| chr6_-_163834852 Show fit | 0.62 |
ENST00000604200.1
|
colon adenocarcinoma hypermethylated (non-protein coding) |
|
| chr3_-_135915146 Show fit | 0.60 |
ENST00000473093.1
|
male-specific lethal 2 homolog (Drosophila) |
|
| chr3_+_49044765 Show fit | 0.50 |
ENST00000429900.2
|
WD repeat domain 6 |
|
| chr10_-_135150367 Show fit | 0.50 |
ENST00000368555.3
ENST00000252939.4 ENST00000368558.1 ENST00000368556.2 |
calcyon neuron-specific vesicular protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of AHR_ARNT2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:2000174 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 1.1 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.0 | 1.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 0.7 | GO:1990709 | presynaptic active zone organization(GO:1990709) |
| 0.2 | 0.7 | GO:1902559 | 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559) |
| 0.1 | 0.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.1 | 0.7 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.0 | 0.7 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.7 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 0.6 | GO:0043335 | protein unfolding(GO:0043335) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 1.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.1 | 1.0 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 0.7 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 0.5 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 0.5 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.4 | GO:0098845 | postsynaptic endosome(GO:0098845) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.9 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.0 | 0.9 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.0 | 0.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 0.7 | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964) |
| 0.1 | 0.7 | GO:0032051 | clathrin light chain binding(GO:0032051) |
| 0.0 | 0.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.6 | GO:0019789 | SUMO transferase activity(GO:0019789) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.1 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 0.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.8 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.7 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.5 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.0 | 0.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.3 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |