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avrg: A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for E4F1

Z-value: 0.60

Motif logo

Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
ENSG00000167967.11 E4F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273645_2273717-1.002.9e-03Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr6_+_32812568 0.75 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32812420 0.42 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr20_+_33146510 0.41 ENST00000397709.1
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr22_+_39101728 0.41 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr19_+_45504688 0.33 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr8_+_94929273 0.31 ENST00000518573.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_+_1941117 0.29 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chrX_-_83757399 0.26 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
HDX
highly divergent homeobox
chr14_-_23388338 0.23 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr22_+_18121356 0.22 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr20_+_34203794 0.21 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr4_+_75311019 0.20 ENST00000502307.1
AREG
amphiregulin
chr2_-_73520667 0.19 ENST00000545030.1
ENST00000436467.2
EGR4
early growth response 4
chr8_-_94928861 0.18 ENST00000607097.1
MIR378D2
microRNA 378d-2
chr1_+_39456895 0.18 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr4_+_75310851 0.18 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr1_+_8378140 0.18 ENST00000377479.2
SLC45A1
solute carrier family 45, member 1
chr17_-_36831156 0.17 ENST00000325814.5
C17orf96
chromosome 17 open reading frame 96
chr22_+_18121562 0.17 ENST00000355028.3
BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr12_-_107168696 0.17 ENST00000551505.1
RP11-144F15.1
Uncharacterized protein
chr20_+_44420570 0.16 ENST00000372622.3
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr22_-_38902300 0.16 ENST00000403230.1
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr1_-_16482554 0.16 ENST00000358432.5
EPHA2
EPH receptor A2
chr7_-_129592700 0.16 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chr7_-_129592471 0.16 ENST00000473814.2
ENST00000490974.1
UBE2H
ubiquitin-conjugating enzyme E2H
chr11_-_33183048 0.15 ENST00000438862.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr17_+_35294075 0.15 ENST00000254457.5
LHX1
LIM homeobox 1
chr17_-_80231557 0.14 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr19_+_45349432 0.14 ENST00000252485.4
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr11_-_6633799 0.14 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr12_+_107168342 0.13 ENST00000392837.4
RIC8B
RIC8 guanine nucleotide exchange factor B
chr4_-_111558135 0.13 ENST00000394598.2
ENST00000394595.3
PITX2
paired-like homeodomain 2
chr1_-_8086343 0.12 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
ERRFI1
ERBB receptor feedback inhibitor 1
chr8_-_29208183 0.12 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chr12_+_107168418 0.12 ENST00000392839.2
ENST00000548914.1
ENST00000355478.2
ENST00000552619.1
ENST00000549643.1
RIC8B
RIC8 guanine nucleotide exchange factor B
chr20_+_44420617 0.12 ENST00000449078.1
ENST00000456939.1
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr2_-_220408260 0.11 ENST00000373891.2
CHPF
chondroitin polymerizing factor
chr4_+_47487285 0.11 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr2_-_128145498 0.11 ENST00000409179.2
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr1_-_47184745 0.11 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr2_-_75426826 0.10 ENST00000305249.5
TACR1
tachykinin receptor 1
chr17_-_80231300 0.10 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chr12_+_122150646 0.10 ENST00000449592.2
TMEM120B
transmembrane protein 120B
chr16_+_68056844 0.10 ENST00000565263.1
DUS2
dihydrouridine synthase 2
chr1_+_26496362 0.09 ENST00000374266.5
ENST00000270812.5
ZNF593
zinc finger protein 593
chr19_-_10024496 0.09 ENST00000593091.1
OLFM2
olfactomedin 2
chr3_-_156877997 0.09 ENST00000295926.3
CCNL1
cyclin L1
chr12_-_93835665 0.09 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr14_-_50053081 0.09 ENST00000396020.3
ENST00000245458.6
RPS29
ribosomal protein S29
chrX_-_153237258 0.09 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_220408430 0.08 ENST00000243776.6
CHPF
chondroitin polymerizing factor
chr2_+_75185619 0.08 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chrX_-_153236819 0.08 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr11_+_12696102 0.08 ENST00000527636.1
ENST00000527376.1
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr11_-_67276100 0.08 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr16_+_68057179 0.08 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
DUS2
dihydrouridine synthase 2
chr10_+_64893039 0.08 ENST00000277746.6
ENST00000435510.2
NRBF2
nuclear receptor binding factor 2
chrX_+_153672468 0.08 ENST00000393600.3
FAM50A
family with sequence similarity 50, member A
chr11_-_33183006 0.07 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr12_+_111471828 0.07 ENST00000261726.6
CUX2
cut-like homeobox 2
chr6_+_44355257 0.07 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr4_-_54930790 0.07 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr8_+_94929110 0.06 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr6_+_15249128 0.06 ENST00000397311.3
JARID2
jumonji, AT rich interactive domain 2
chr16_+_68057153 0.06 ENST00000358896.6
ENST00000568099.2
DUS2
dihydrouridine synthase 2
chr10_-_50970322 0.06 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chrX_-_13835461 0.06 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr3_-_185655795 0.06 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr11_+_111411384 0.06 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
LAYN
layilin
chr2_-_222437049 0.06 ENST00000541600.1
EPHA4
EPH receptor A4
chr3_+_185304059 0.06 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_-_32110467 0.06 ENST00000440872.2
ENST00000373703.4
PEF1
penta-EF-hand domain containing 1
chr19_-_59066452 0.05 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr2_-_62115725 0.05 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr6_-_31774714 0.05 ENST00000375661.5
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_+_180199393 0.05 ENST00000263726.2
LHX4
LIM homeobox 4
chr4_-_186456766 0.05 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr5_+_68513557 0.05 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr1_+_2005425 0.05 ENST00000461106.2
PRKCZ
protein kinase C, zeta
chr6_-_29595779 0.05 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_-_98290087 0.05 ENST00000322128.3
TSPYL5
TSPY-like 5
chr17_+_25621102 0.05 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr6_+_139456226 0.05 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chrX_+_153237740 0.04 ENST00000369982.4
TMEM187
transmembrane protein 187
chr6_-_34664612 0.04 ENST00000374023.3
ENST00000374026.3
C6orf106
chromosome 6 open reading frame 106
chr10_-_50970382 0.04 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr16_-_46782221 0.04 ENST00000394809.4
MYLK3
myosin light chain kinase 3
chr20_+_58179582 0.04 ENST00000371015.1
ENST00000395639.4
PHACTR3
phosphatase and actin regulator 3
chr6_-_163148700 0.04 ENST00000366894.1
ENST00000338468.3
PARK2
parkin RBR E3 ubiquitin protein ligase
chr20_-_44600810 0.04 ENST00000322927.2
ENST00000426788.1
ZNF335
zinc finger protein 335
chr12_-_93836028 0.04 ENST00000318066.2
UBE2N
ubiquitin-conjugating enzyme E2N
chr2_-_62115659 0.03 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr17_-_40540484 0.03 ENST00000588969.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chrX_-_13835147 0.03 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr3_+_139654018 0.03 ENST00000458420.3
CLSTN2
calsyntenin 2
chr1_+_151682909 0.03 ENST00000326413.3
ENST00000442233.2
RIIAD1
AL589765.1
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
Uncharacterized protein; cDNA FLJ36032 fis, clone TESTI2017069
chr17_+_71161140 0.03 ENST00000357585.2
SSTR2
somatostatin receptor 2
chr22_-_38902325 0.03 ENST00000396821.3
ENST00000381633.3
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr6_+_33176265 0.03 ENST00000374656.4
RING1
ring finger protein 1
chr11_+_111410998 0.03 ENST00000533999.1
LAYN
layilin
chr8_+_94929077 0.03 ENST00000297598.4
ENST00000520614.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr9_-_131644306 0.03 ENST00000302586.3
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr20_-_62258394 0.03 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr19_+_54704610 0.03 ENST00000302907.4
RPS9
ribosomal protein S9
chr3_+_185303962 0.03 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr19_+_52693259 0.03 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr19_-_46088068 0.03 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chrX_+_152224766 0.03 ENST00000370265.4
ENST00000447306.1
PNMA3
paraneoplastic Ma antigen 3
chr1_+_70820451 0.03 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr17_+_41476327 0.03 ENST00000320033.4
ARL4D
ADP-ribosylation factor-like 4D
chr15_+_50716645 0.03 ENST00000560982.1
USP8
ubiquitin specific peptidase 8
chr17_+_685513 0.03 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr4_-_186456652 0.03 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr6_+_163148973 0.02 ENST00000366888.2
PACRG
PARK2 co-regulated
chr5_+_133706865 0.02 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr11_+_66188475 0.02 ENST00000311034.2
NPAS4
neuronal PAS domain protein 4
chr19_+_13858593 0.02 ENST00000221554.8
CCDC130
coiled-coil domain containing 130
chr15_-_53082178 0.02 ENST00000305901.5
ONECUT1
one cut homeobox 1
chr16_+_27561449 0.01 ENST00000261588.4
KIAA0556
KIAA0556
chr1_-_212208842 0.01 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
INTS7
integrator complex subunit 7
chr12_+_122516626 0.01 ENST00000319080.7
MLXIP
MLX interacting protein
chr6_-_144416737 0.01 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr19_-_59066327 0.01 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr9_-_131644202 0.01 ENST00000320665.6
ENST00000436267.2
CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr12_-_110011288 0.01 ENST00000540016.1
ENST00000266839.5
MMAB
methylmalonic aciduria (cobalamin deficiency) cblB type
chr17_-_40540377 0.01 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr3_+_140660743 0.01 ENST00000453248.2
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chrX_-_73834449 0.01 ENST00000332687.6
ENST00000349225.2
RLIM
ring finger protein, LIM domain interacting
chr19_+_54704990 0.01 ENST00000391753.2
RPS9
ribosomal protein S9
chr11_+_18720316 0.01 ENST00000280734.2
TMEM86A
transmembrane protein 86A
chr19_+_54704718 0.01 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
RPS9
ribosomal protein S9
chr8_+_94929168 0.00 ENST00000518107.1
ENST00000396200.3
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr8_-_116680833 0.00 ENST00000220888.5
TRPS1
trichorhinophalangeal syndrome I
chr18_+_23806382 0.00 ENST00000400466.2
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr19_+_54705025 0.00 ENST00000441429.1
RPS9
ribosomal protein S9
chr16_-_3767551 0.00 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr16_+_29973351 0.00 ENST00000602948.1
ENST00000279396.6
ENST00000575829.2
ENST00000561899.2
TMEM219
transmembrane protein 219
chr6_-_163148780 0.00 ENST00000366892.1
ENST00000366898.1
ENST00000366897.1
ENST00000366896.1
PARK2
parkin RBR E3 ubiquitin protein ligase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:2000744 anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744)
0.0 0.4 GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.2 GO:0019046 release from viral latency(GO:0019046)
0.0 0.4 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0060460 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) superior vena cava morphogenesis(GO:0060578)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:0002035 brain renin-angiotensin system(GO:0002035) angiotensin-mediated drinking behavior(GO:0003051) response to ozone(GO:0010193) operant conditioning(GO:0035106) positive regulation of saliva secretion(GO:0046878)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:1990637 response to prolactin(GO:1990637)
0.0 0.1 GO:1903722 regulation of centriole elongation(GO:1903722)
0.0 0.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.1 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 1.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.0 GO:1904862 inhibitory synapse assembly(GO:1904862)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0044754 autolysosome(GO:0044754)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.0 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 1.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0000035 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.4 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.4 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.2 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)