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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ZNF8

Z-value: 1.14

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_58790358-0.663.4e-01Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_56591978 1.03 ENST00000583656.1
MTMR4
myotubularin related protein 4
chr6_+_29691056 0.96 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr17_+_48585794 0.94 ENST00000576179.1
ENST00000419930.1
MYCBPAP
MYCBP associated protein
chr12_-_74686314 0.92 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr1_-_186344802 0.78 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr12_+_104235229 0.67 ENST00000551650.1
RP11-650K20.3
Uncharacterized protein
chr6_+_29691198 0.64 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr2_-_240322685 0.55 ENST00000544989.1
HDAC4
histone deacetylase 4
chr1_+_70671363 0.54 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr11_+_46402482 0.42 ENST00000441869.1
MDK
midkine (neurite growth-promoting factor 2)
chr5_+_138677515 0.42 ENST00000265192.4
ENST00000511706.1
PAIP2
poly(A) binding protein interacting protein 2
chr1_+_186344883 0.39 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr10_+_135192695 0.37 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
PAOX
polyamine oxidase (exo-N4-amino)
chr10_-_1034237 0.37 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr1_+_25664408 0.36 ENST00000374358.4
TMEM50A
transmembrane protein 50A
chr17_-_27169745 0.35 ENST00000583307.1
ENST00000581229.1
ENST00000582266.1
ENST00000577376.1
ENST00000577682.1
ENST00000581381.1
ENST00000341217.5
ENST00000581407.1
ENST00000583522.1
FAM222B
family with sequence similarity 222, member B
chr3_-_46000146 0.35 ENST00000438446.1
FYCO1
FYVE and coiled-coil domain containing 1
chr19_-_18392422 0.35 ENST00000252818.3
JUND
jun D proto-oncogene
chr11_+_69455855 0.35 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr17_+_48585902 0.34 ENST00000452039.1
MYCBPAP
MYCBP associated protein
chr8_+_61429416 0.33 ENST00000262646.7
ENST00000531289.1
RAB2A
RAB2A, member RAS oncogene family
chr11_+_46402583 0.32 ENST00000359803.3
MDK
midkine (neurite growth-promoting factor 2)
chr1_+_186344945 0.28 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr3_-_9994021 0.26 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr2_-_240322643 0.26 ENST00000345617.3
HDAC4
histone deacetylase 4
chr12_-_46662888 0.25 ENST00000546893.1
SLC38A1
solute carrier family 38, member 1
chr5_-_43515125 0.25 ENST00000509489.1
C5orf34
chromosome 5 open reading frame 34
chr9_+_96026230 0.24 ENST00000448251.1
WNK2
WNK lysine deficient protein kinase 2
chr2_+_198365122 0.23 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr9_-_94711007 0.23 ENST00000375715.1
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr9_-_32552551 0.22 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr19_-_5903714 0.22 ENST00000586349.1
ENST00000585661.1
ENST00000308961.4
ENST00000592634.1
ENST00000418389.2
ENST00000252675.5
AC024592.12
NDUFA11
FUT5
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr22_+_30163340 0.21 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr13_+_21750780 0.19 ENST00000309594.4
MRP63
mitochondrial ribosomal protein 63
chr2_+_169926047 0.19 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_+_75181292 0.19 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr8_+_145064233 0.19 ENST00000529301.1
ENST00000395068.4
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr11_-_46638378 0.18 ENST00000529192.1
HARBI1
harbinger transposase derived 1
chr11_+_13690200 0.18 ENST00000354817.3
FAR1
fatty acyl CoA reductase 1
chr6_+_53659746 0.16 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr8_-_109260897 0.13 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr2_+_173600514 0.12 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_173600565 0.12 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr13_+_53029564 0.11 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
CKAP2
cytoskeleton associated protein 2
chr22_+_37415676 0.11 ENST00000401419.3
MPST
mercaptopyruvate sulfurtransferase
chr6_+_116601265 0.11 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr1_-_246670614 0.10 ENST00000403792.3
SMYD3
SET and MYND domain containing 3
chr7_+_117824086 0.10 ENST00000249299.2
ENST00000424702.1
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr5_+_10353780 0.10 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr3_+_49236910 0.09 ENST00000452691.2
ENST00000366429.2
CCDC36
coiled-coil domain containing 36
chr22_+_37415728 0.09 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr11_-_61560254 0.09 ENST00000543510.1
TMEM258
transmembrane protein 258
chr12_+_79258444 0.08 ENST00000261205.4
SYT1
synaptotagmin I
chr5_+_102455968 0.08 ENST00000358359.3
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr1_-_100715372 0.08 ENST00000370131.3
ENST00000370132.4
DBT
dihydrolipoamide branched chain transacylase E2
chr7_+_100303676 0.08 ENST00000303151.4
POP7
processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
chrX_+_1387693 0.07 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr2_+_172290707 0.07 ENST00000375255.3
ENST00000539783.1
DCAF17
DDB1 and CUL4 associated factor 17
chr22_+_37415776 0.07 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST
mercaptopyruvate sulfurtransferase
chr22_-_30162924 0.06 ENST00000344318.3
ENST00000397781.3
ZMAT5
zinc finger, matrin-type 5
chr10_-_13043697 0.06 ENST00000378825.3
CCDC3
coiled-coil domain containing 3
chr15_+_85523671 0.06 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr14_+_51706886 0.05 ENST00000457354.2
TMX1
thioredoxin-related transmembrane protein 1
chr20_+_37377085 0.05 ENST00000243903.4
ACTR5
ARP5 actin-related protein 5 homolog (yeast)
chr13_-_25861530 0.05 ENST00000540661.1
MTMR6
myotubularin related protein 6
chr9_+_1050331 0.05 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr1_-_55266926 0.05 ENST00000371276.4
TTC22
tetratricopeptide repeat domain 22
chr5_+_89854595 0.05 ENST00000405460.2
GPR98
G protein-coupled receptor 98
chr6_+_106959718 0.04 ENST00000369066.3
AIM1
absent in melanoma 1
chr7_+_1748798 0.04 ENST00000561626.1
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr8_+_38244638 0.04 ENST00000526356.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr22_+_37415700 0.04 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr11_+_46638805 0.03 ENST00000434074.1
ENST00000312040.4
ENST00000451945.1
ATG13
autophagy related 13
chr2_+_87144738 0.03 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr17_+_34136459 0.02 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chrX_+_128913906 0.01 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr19_+_35739782 0.01 ENST00000347609.4
LSR
lipolysis stimulated lipoprotein receptor
chr12_+_79258547 0.01 ENST00000457153.2
SYT1
synaptotagmin I
chr4_-_52904425 0.00 ENST00000535450.1
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0045799 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.2 1.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1 0.7 GO:0030421 defecation(GO:0030421)
0.1 1.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.4 GO:0009447 putrescine catabolic process(GO:0009447)
0.0 0.2 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.4 GO:0070141 response to UV-A(GO:0070141)
0.0 0.4 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.1 GO:0060629 meiotic DNA double-strand break formation(GO:0042138) regulation of homologous chromosome segregation(GO:0060629)
0.0 0.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.2 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.2 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.8 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.3 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.1 0.4 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 1.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.2 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.8 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.2 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm