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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ZNF524
Z-value: 2.49
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Transcription factors associated with ZNF524
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF524 | hg19_v2_chr19_+_56111680_56111735 | -0.22 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_121477039 Show fit | 2.85 |
ENST00000257570.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr12_-_121476959 Show fit | 2.65 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr12_-_56753858 Show fit | 2.27 |
ENST00000314128.4
ENST00000557235.1 ENST00000418572.2 |
signal transducer and activator of transcription 2, 113kDa |
|
| chr19_+_8429031 Show fit | 1.70 |
ENST00000301455.2
ENST00000541807.1 ENST00000393962.2 |
angiopoietin-like 4 |
|
| chr10_+_91092241 Show fit | 1.61 |
ENST00000371811.4
|
interferon-induced protein with tetratricopeptide repeats 3 |
|
| chr16_+_56642489 Show fit | 1.61 |
ENST00000561491.1
|
metallothionein 2A |
|
| chr12_+_113354341 Show fit | 1.55 |
ENST00000553152.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr8_+_25042192 Show fit | 1.48 |
ENST00000410074.1
|
dedicator of cytokinesis 5 |
|
| chr5_+_135383008 Show fit | 1.43 |
ENST00000508767.1
ENST00000604555.1 |
transforming growth factor, beta-induced, 68kDa |
|
| chr12_+_14369524 Show fit | 1.38 |
ENST00000538329.1
|
RP11-134N1.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF524
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.4 | 2.8 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.2 | 2.3 | GO:0010911 | regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 0.1 | 2.1 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 0.0 | 2.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 2.0 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 1.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.5 | 1.6 | GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) |
| 0.2 | 1.6 | GO:0051005 | negative regulation of lipoprotein lipase activity(GO:0051005) |
| 0.2 | 1.5 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 1.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 1.7 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.2 | 1.6 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 1.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 1.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 1.2 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 1.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 1.1 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.0 | 1.1 | GO:0031201 | SNARE complex(GO:0031201) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.4 | 2.8 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.0 | 2.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 2.4 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 2.3 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 2.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 2.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.2 | 2.0 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.4 | 1.7 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 1.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 2.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.5 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.4 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 3.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 3.2 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 3.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 2.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 2.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 2.2 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.1 | 1.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.3 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |