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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ZNF282
Z-value: 1.70
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Transcription factors associated with ZNF282
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF282 | hg19_v2_chr7_+_148892629_148892651 | -0.66 | 3.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_50970919 Show fit | 3.03 |
ENST00000329363.4
ENST00000437588.1 |
outer dense fiber of sperm tails 3B |
|
| chr22_-_50970566 Show fit | 2.87 |
ENST00000405135.1
ENST00000401779.1 |
outer dense fiber of sperm tails 3B |
|
| chr22_-_50970506 Show fit | 2.60 |
ENST00000428989.2
ENST00000403326.1 |
outer dense fiber of sperm tails 3B |
|
| chr11_-_321340 Show fit | 2.34 |
ENST00000526811.1
|
interferon induced transmembrane protein 3 |
|
| chr8_-_23261589 Show fit | 2.06 |
ENST00000524168.1
ENST00000523833.2 ENST00000519243.1 ENST00000389131.3 |
lysyl oxidase-like 2 |
|
| chr9_+_126777676 Show fit | 1.82 |
ENST00000488674.2
|
LIM homeobox 2 |
|
| chr6_+_144471643 Show fit | 1.20 |
ENST00000367568.4
|
syntaxin 11 |
|
| chr22_-_24641027 Show fit | 1.19 |
ENST00000398292.3
ENST00000263112.7 ENST00000418439.2 ENST00000424217.1 ENST00000327365.4 |
gamma-glutamyltransferase 5 |
|
| chr5_+_86415919 Show fit | 1.07 |
ENST00000515750.1
|
RP11-72L22.1 |
|
| chr17_-_56605341 Show fit | 1.04 |
ENST00000583114.1
|
septin 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF282
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.5 | 2.1 | GO:0018277 | protein deamination(GO:0018277) |
| 0.1 | 1.8 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.0 | 1.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 1.2 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 1.2 | GO:0099500 | synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500) |
| 0.2 | 1.0 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.1 | 0.6 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.1 | 0.6 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) homocysteine catabolic process(GO:0043418) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 2.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.9 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.2 | 0.6 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.1 | 0.6 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.6 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.1 | 0.5 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 0.5 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.5 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.0 | 1.7 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.2 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 0.6 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.1 | 0.6 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.6 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.6 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.1 | 0.5 | GO:0052811 | 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) |
| 0.1 | 0.4 | GO:0004794 | L-threonine ammonia-lyase activity(GO:0004794) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.6 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.2 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 1.2 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.8 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 0.6 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 0.6 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.4 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.4 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |