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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ZKSCAN3

Z-value: 1.43

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.396.1e-01Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39786962 11.72 ENST00000333625.2
IFNL1
interferon, lambda 1
chr19_-_39735646 2.10 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_+_39759154 1.90 ENST00000331982.5
IFNL2
interferon, lambda 2
chr1_-_935361 1.15 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr12_-_3982511 0.94 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr12_-_3982548 0.68 ENST00000397096.2
ENST00000447133.3
ENST00000450737.2
PARP11
poly (ADP-ribose) polymerase family, member 11
chr7_+_1084206 0.59 ENST00000444847.1
GPR146
G protein-coupled receptor 146
chr7_-_155089251 0.56 ENST00000609974.1
AC144652.1
AC144652.1
chr19_-_4182530 0.56 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr9_+_127023704 0.55 ENST00000373596.1
ENST00000425237.1
NEK6
NIMA-related kinase 6
chr17_+_32597232 0.54 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
CCL7
chemokine (C-C motif) ligand 7
chr19_+_54372639 0.52 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr19_-_4182497 0.48 ENST00000597896.1
SIRT6
sirtuin 6
chr12_+_113796347 0.47 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr2_+_191745535 0.46 ENST00000320717.3
GLS
glutaminase
chr5_-_180235755 0.43 ENST00000502678.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr18_-_74728998 0.41 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr1_+_114472992 0.35 ENST00000514621.1
HIPK1
homeodomain interacting protein kinase 1
chr15_+_74610894 0.35 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr11_+_66610883 0.35 ENST00000309657.3
ENST00000524506.1
RCE1
Ras converting CAAX endopeptidase 1
chr17_+_36908984 0.34 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr1_+_114473350 0.33 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr4_-_169239921 0.31 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr16_-_1429010 0.31 ENST00000513783.1
UNKL
unkempt family zinc finger-like
chr1_+_3598871 0.26 ENST00000603362.1
ENST00000604479.1
TP73
tumor protein p73
chrX_-_153775426 0.26 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr19_+_32836499 0.25 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr19_-_42348692 0.24 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chr2_-_61244308 0.23 ENST00000407787.1
ENST00000398658.2
PUS10
pseudouridylate synthase 10
chr1_-_19811996 0.20 ENST00000264203.3
ENST00000401084.2
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr1_-_86622421 0.20 ENST00000370571.2
COL24A1
collagen, type XXIV, alpha 1
chr5_-_95297534 0.19 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr6_+_116850174 0.17 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr21_+_39668831 0.13 ENST00000419868.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr5_+_140079919 0.12 ENST00000274712.3
ZMAT2
zinc finger, matrin-type 2
chr21_+_39668478 0.12 ENST00000398927.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_+_23352133 0.11 ENST00000379361.4
PTCHD1
patched domain containing 1
chr12_+_109535923 0.11 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr19_+_52693259 0.11 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr2_-_175351744 0.11 ENST00000295500.4
ENST00000392552.2
ENST00000392551.2
GPR155
G protein-coupled receptor 155
chr16_-_745946 0.10 ENST00000562563.1
FBXL16
F-box and leucine-rich repeat protein 16
chr11_-_67272794 0.09 ENST00000436757.2
ENST00000356404.3
PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr16_-_832054 0.08 ENST00000543963.1
MSLNL
mesothelin-like
chrX_+_153775821 0.07 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr16_-_832926 0.07 ENST00000293892.3
MSLNL
mesothelin-like
chr17_-_60142609 0.07 ENST00000397786.2
MED13
mediator complex subunit 13
chr6_-_31508304 0.06 ENST00000376177.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr16_-_4039001 0.05 ENST00000576936.1
ADCY9
adenylate cyclase 9
chr22_+_50312379 0.04 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr14_-_106926724 0.04 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr5_-_65017921 0.04 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr11_-_61062762 0.04 ENST00000335613.5
VWCE
von Willebrand factor C and EGF domains
chr1_-_28415204 0.03 ENST00000373871.3
EYA3
eyes absent homolog 3 (Drosophila)
chr19_-_49258606 0.02 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_-_19811132 0.02 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta
chr6_+_32936353 0.01 ENST00000374825.4
BRD2
bromodomain containing 2
chr22_+_50312274 0.00 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.3 1.0 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.1 0.3 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 0.4 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.1 0.5 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 1.9 GO:0002385 mucosal immune response(GO:0002385)
0.1 0.5 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1 0.7 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.4 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 0.2 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
0.0 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 2.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.6 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 0.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.3 1.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.4 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0071203 WASH complex(GO:0071203)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 0.5 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.1 15.7 GO:0005125 cytokine activity(GO:0005125)
0.0 0.4 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.0 1.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)