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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for ZIC3_ZIC4

Z-value: 0.76

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Transcription factors associated with ZIC3_ZIC4

Gene Symbol Gene ID Gene Info
ZIC3
ENSG00000156925.7 Zic family member 3
ZIC4
ENSG00000174963.13 Zic family member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC3hg19_v2_chrX_+_136648643_1366487110.964.3e-02Click!

Activity profile of ZIC3_ZIC4 motif

Sorted Z-values of ZIC3_ZIC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_302918 0.95 ENST00000599994.1
AC187652.1
Protein LOC100996433
chr8_-_145060593 0.71 ENST00000313059.5
ENST00000524918.1
ENST00000313028.7
ENST00000525773.1
PARP10
poly (ADP-ribose) polymerase family, member 10
chr20_+_34203794 0.64 ENST00000374273.3
SPAG4
sperm associated antigen 4
chr17_-_43045439 0.62 ENST00000253407.3
C1QL1
complement component 1, q subcomponent-like 1
chr20_+_61340179 0.48 ENST00000370501.3
NTSR1
neurotensin receptor 1 (high affinity)
chr12_-_54779511 0.47 ENST00000551109.1
ENST00000546970.1
ZNF385A
zinc finger protein 385A
chr2_+_8822113 0.41 ENST00000396290.1
ENST00000331129.3
ID2
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr19_-_31840130 0.40 ENST00000558569.1
TSHZ3
teashirt zinc finger homeobox 3
chr10_-_79397547 0.38 ENST00000481070.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_+_38179969 0.37 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr6_+_32006159 0.37 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr9_+_100174232 0.36 ENST00000355295.4
TDRD7
tudor domain containing 7
chr9_+_100174344 0.36 ENST00000422139.2
TDRD7
tudor domain containing 7
chr11_-_60719213 0.35 ENST00000227880.3
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr10_+_13141441 0.35 ENST00000263036.5
OPTN
optineurin
chr5_-_176923803 0.34 ENST00000506161.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr19_-_58609570 0.33 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18
zinc finger and SCAN domain containing 18
chr15_+_80351910 0.32 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr10_+_13141585 0.31 ENST00000378764.2
OPTN
optineurin
chr7_-_99774945 0.31 ENST00000292377.2
GPC2
glypican 2
chr5_-_176924562 0.31 ENST00000359895.2
ENST00000355572.2
ENST00000355841.2
ENST00000393551.1
ENST00000505074.1
ENST00000356618.4
ENST00000393546.4
PDLIM7
PDZ and LIM domain 7 (enigma)
chr17_-_39183452 0.31 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr1_-_16400086 0.30 ENST00000375662.4
FAM131C
family with sequence similarity 131, member C
chr16_-_88717482 0.30 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr21_-_45196326 0.30 ENST00000291568.5
CSTB
cystatin B (stefin B)
chr12_-_132834281 0.29 ENST00000411988.2
ENST00000535228.1
GALNT9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)
chr12_+_132312931 0.27 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
MMP17
matrix metallopeptidase 17 (membrane-inserted)
chr1_-_153521714 0.27 ENST00000368713.3
S100A3
S100 calcium binding protein A3
chr19_+_13906250 0.27 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr22_+_43506747 0.26 ENST00000216115.2
BIK
BCL2-interacting killer (apoptosis-inducing)
chr5_-_176923846 0.26 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr16_+_29466426 0.26 ENST00000567248.1
SLX1B
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr17_-_79917645 0.25 ENST00000477214.1
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr10_+_13142075 0.25 ENST00000378757.2
ENST00000430081.1
ENST00000378752.3
ENST00000378748.3
OPTN
optineurin
chr11_-_65150103 0.24 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45
solute carrier family 25, member 45
chr1_+_155293702 0.24 ENST00000368347.4
RUSC1
RUN and SH3 domain containing 1
chr14_+_100848311 0.23 ENST00000542471.2
WDR25
WD repeat domain 25
chr11_+_73675873 0.23 ENST00000537753.1
ENST00000542350.1
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr3_-_176914998 0.23 ENST00000431421.1
ENST00000422066.1
ENST00000413084.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr14_+_24641062 0.23 ENST00000311457.3
ENST00000557806.1
ENST00000559919.1
REC8
REC8 meiotic recombination protein
chr4_+_81951957 0.22 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr16_+_56691838 0.22 ENST00000394501.2
MT1F
metallothionein 1F
chr19_+_45251804 0.22 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr2_+_85132749 0.22 ENST00000233143.4
TMSB10
thymosin beta 10
chr19_-_10024496 0.22 ENST00000593091.1
OLFM2
olfactomedin 2
chr1_-_21503337 0.22 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr19_-_1174226 0.22 ENST00000587024.1
ENST00000361757.3
SBNO2
strawberry notch homolog 2 (Drosophila)
chrX_+_51927919 0.21 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr16_-_29466285 0.21 ENST00000330978.3
BOLA2
bolA family member 2
chrX_-_54070607 0.20 ENST00000338154.6
ENST00000338946.6
PHF8
PHD finger protein 8
chr1_-_153521597 0.20 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr10_+_13142225 0.19 ENST00000378747.3
OPTN
optineurin
chr3_-_129035120 0.19 ENST00000333762.4
H1FX
H1 histone family, member X
chr22_-_36635598 0.19 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr11_+_58938903 0.19 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr10_+_71561630 0.19 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr2_+_101436564 0.19 ENST00000335681.5
NPAS2
neuronal PAS domain protein 2
chr21_+_37507210 0.18 ENST00000290354.5
CBR3
carbonyl reductase 3
chr22_+_22723969 0.18 ENST00000390295.2
IGLV7-46
immunoglobulin lambda variable 7-46 (gene/pseudogene)
chr6_+_32006042 0.18 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr2_-_73869508 0.18 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr1_-_6240183 0.18 ENST00000262450.3
ENST00000378021.1
CHD5
chromodomain helicase DNA binding protein 5
chr20_-_56286479 0.18 ENST00000265626.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr16_-_30204987 0.18 ENST00000569282.1
ENST00000567436.1
BOLA2B
bolA family member 2B
chr19_+_589893 0.18 ENST00000251287.2
HCN2
hyperpolarization activated cyclic nucleotide-gated potassium channel 2
chr16_+_29465822 0.17 ENST00000330181.5
ENST00000351581.4
SLX1B
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr1_-_212873267 0.17 ENST00000243440.1
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr16_-_30205627 0.17 ENST00000305321.4
BOLA2B
bolA family member 2B
chr9_-_114246332 0.17 ENST00000602978.1
KIAA0368
KIAA0368
chr15_+_90728145 0.17 ENST00000561085.1
ENST00000379122.3
ENST00000332496.6
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr17_-_42988004 0.17 ENST00000586125.1
ENST00000591880.1
GFAP
glial fibrillary acidic protein
chr11_+_69061594 0.17 ENST00000441339.2
ENST00000308946.3
ENST00000535407.1
MYEOV
myeloma overexpressed
chr3_-_50540854 0.16 ENST00000423994.2
ENST00000424201.2
ENST00000479441.1
ENST00000429770.1
CACNA2D2
calcium channel, voltage-dependent, alpha 2/delta subunit 2
chr16_+_30205225 0.16 ENST00000345535.4
ENST00000251303.6
SLX1A
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr12_+_49932886 0.16 ENST00000257981.6
KCNH3
potassium voltage-gated channel, subfamily H (eag-related), member 3
chr19_+_18077881 0.16 ENST00000609922.1
KCNN1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
chr16_+_56691911 0.15 ENST00000568475.1
MT1F
metallothionein 1F
chr16_+_56691606 0.15 ENST00000334350.6
MT1F
metallothionein 1F
chr16_+_9185450 0.15 ENST00000327827.7
C16orf72
chromosome 16 open reading frame 72
chr3_+_11196206 0.15 ENST00000431010.2
HRH1
histamine receptor H1
chr1_+_28995231 0.15 ENST00000373816.1
GMEB1
glucocorticoid modulatory element binding protein 1
chr16_+_4897632 0.15 ENST00000262376.6
UBN1
ubinuclein 1
chr2_-_233792837 0.14 ENST00000373552.4
ENST00000409079.1
NGEF
neuronal guanine nucleotide exchange factor
chrX_-_54070388 0.14 ENST00000415025.1
PHF8
PHD finger protein 8
chr17_+_78194205 0.14 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr19_+_17970693 0.14 ENST00000600147.1
ENST00000599898.1
RPL18A
ribosomal protein L18a
chr5_-_157002775 0.14 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr12_-_7244469 0.14 ENST00000538050.1
ENST00000536053.2
C1R
complement component 1, r subcomponent
chr16_-_2059797 0.14 ENST00000563630.1
ZNF598
zinc finger protein 598
chr16_+_58035277 0.14 ENST00000219281.3
ENST00000539737.2
ENST00000423271.3
ENST00000561568.1
ENST00000563149.1
USB1
U6 snRNA biogenesis 1
chr6_-_38607673 0.14 ENST00000481247.1
BTBD9
BTB (POZ) domain containing 9
chr10_+_112257596 0.14 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr19_-_23869999 0.13 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
ZNF675
zinc finger protein 675
chr12_-_51420128 0.13 ENST00000262051.7
ENST00000547732.1
ENST00000262052.5
ENST00000546488.1
ENST00000550714.1
ENST00000548193.1
ENST00000547579.1
ENST00000546743.1
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr11_+_64781575 0.13 ENST00000246747.4
ENST00000529384.1
ARL2
ADP-ribosylation factor-like 2
chr13_-_41111323 0.13 ENST00000595486.1
AL133318.1
Uncharacterized protein
chr11_-_125932685 0.13 ENST00000527967.1
CDON
cell adhesion associated, oncogene regulated
chr22_+_19705928 0.13 ENST00000383045.3
ENST00000438754.2
SEPT5
septin 5
chr14_+_24630465 0.13 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr19_+_17970677 0.13 ENST00000222247.5
RPL18A
ribosomal protein L18a
chr5_-_157002749 0.13 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr1_+_3370990 0.13 ENST00000378378.4
ARHGEF16
Rho guanine nucleotide exchange factor (GEF) 16
chr17_-_56065540 0.13 ENST00000583932.1
VEZF1
vascular endothelial zinc finger 1
chr17_+_5981270 0.13 ENST00000571973.1
WSCD1
WSC domain containing 1
chr15_+_80351977 0.13 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
ZFAND6
zinc finger, AN1-type domain 6
chr17_-_78194124 0.12 ENST00000570427.1
ENST00000570923.1
SGSH
N-sulfoglucosamine sulfohydrolase
chr4_-_15656923 0.12 ENST00000382358.4
ENST00000412094.2
ENST00000341285.3
FBXL5
F-box and leucine-rich repeat protein 5
chr2_+_23608064 0.12 ENST00000486442.1
KLHL29
kelch-like family member 29
chr22_-_20368028 0.12 ENST00000404912.1
GGTLC3
gamma-glutamyltransferase light chain 3
chr11_+_134146635 0.12 ENST00000431683.2
GLB1L3
galactosidase, beta 1-like 3
chr17_+_48638371 0.12 ENST00000360761.4
ENST00000352832.5
ENST00000354983.4
CACNA1G
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr5_+_43192311 0.12 ENST00000326035.2
NIM1
NIM1 serine/threonine protein kinase
chr16_+_2059872 0.12 ENST00000567649.1
NPW
neuropeptide W
chr6_+_36098262 0.12 ENST00000373761.6
ENST00000373766.5
MAPK13
mitogen-activated protein kinase 13
chr15_-_41408409 0.12 ENST00000361937.3
INO80
INO80 complex subunit
chr1_-_235814048 0.12 ENST00000450593.1
ENST00000366598.4
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr3_-_134093395 0.12 ENST00000249883.5
AMOTL2
angiomotin like 2
chr6_+_36097992 0.12 ENST00000211287.4
MAPK13
mitogen-activated protein kinase 13
chr16_+_24550857 0.12 ENST00000568015.1
RBBP6
retinoblastoma binding protein 6
chr5_-_126366500 0.11 ENST00000308660.5
MARCH3
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
chr11_+_66790816 0.11 ENST00000527043.1
SYT12
synaptotagmin XII
chr3_+_183948161 0.11 ENST00000426955.2
VWA5B2
von Willebrand factor A domain containing 5B2
chr17_-_39646116 0.11 ENST00000328119.6
KRT36
keratin 36
chr11_+_120081475 0.11 ENST00000328965.4
OAF
OAF homolog (Drosophila)
chr5_-_131563501 0.11 ENST00000401867.1
ENST00000379086.1
ENST00000418055.1
ENST00000453286.1
ENST00000166534.4
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr10_-_126849626 0.11 ENST00000530884.1
CTBP2
C-terminal binding protein 2
chr2_+_109150887 0.11 ENST00000428064.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_+_36098363 0.11 ENST00000373759.1
MAPK13
mitogen-activated protein kinase 13
chr22_-_39636914 0.11 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr6_+_15249128 0.11 ENST00000397311.3
JARID2
jumonji, AT rich interactive domain 2
chr2_+_105050794 0.11 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr12_-_51420108 0.11 ENST00000547198.1
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr18_-_51750948 0.11 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr19_+_56165480 0.11 ENST00000450554.2
U2AF2
U2 small nuclear RNA auxiliary factor 2
chr16_-_29465668 0.11 ENST00000569622.1
RP11-345J4.5
BolA-like protein 2
chr14_+_29236269 0.11 ENST00000313071.4
FOXG1
forkhead box G1
chrX_+_134555863 0.10 ENST00000417443.2
LINC00086
long intergenic non-protein coding RNA 86
chr1_+_43232913 0.10 ENST00000372525.5
ENST00000536543.1
C1orf50
chromosome 1 open reading frame 50
chr19_-_40791211 0.10 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr11_-_65667997 0.10 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr16_+_89989687 0.10 ENST00000315491.7
ENST00000555576.1
ENST00000554336.1
ENST00000553967.1
TUBB3
Tubulin beta-3 chain
chr2_+_219824357 0.10 ENST00000302625.4
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr5_-_110074603 0.10 ENST00000515278.2
TMEM232
transmembrane protein 232
chr16_+_777739 0.10 ENST00000563792.1
HAGHL
hydroxyacylglutathione hydrolase-like
chr11_-_67276100 0.10 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chrX_+_13707235 0.10 ENST00000464506.1
RAB9A
RAB9A, member RAS oncogene family
chr20_+_44563267 0.10 ENST00000372409.3
PCIF1
PDX1 C-terminal inhibiting factor 1
chr2_-_202645612 0.10 ENST00000409632.2
ENST00000410052.1
ENST00000467448.1
ALS2
amyotrophic lateral sclerosis 2 (juvenile)
chr11_-_65667884 0.10 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr3_-_118753792 0.10 ENST00000480431.1
IGSF11
immunoglobulin superfamily, member 11
chr7_-_150020578 0.10 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr5_+_176873446 0.10 ENST00000507881.1
PRR7
proline rich 7 (synaptic)
chr17_+_77030267 0.10 ENST00000581774.1
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr11_-_407103 0.10 ENST00000526395.1
SIGIRR
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
chr15_-_91565770 0.10 ENST00000535906.1
ENST00000333371.3
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr2_+_10183651 0.10 ENST00000305883.1
KLF11
Kruppel-like factor 11
chr1_+_6673745 0.09 ENST00000377648.4
PHF13
PHD finger protein 13
chr9_-_74383799 0.09 ENST00000377044.4
TMEM2
transmembrane protein 2
chr17_-_58469474 0.09 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr1_+_2407754 0.09 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr1_+_156024552 0.09 ENST00000368304.5
ENST00000368302.3
LAMTOR2
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr19_-_2721412 0.09 ENST00000323469.4
DIRAS1
DIRAS family, GTP-binding RAS-like 1
chr10_+_71561649 0.09 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr12_-_48152853 0.09 ENST00000171000.4
RAPGEF3
Rap guanine nucleotide exchange factor (GEF) 3
chr1_+_183441500 0.09 ENST00000456731.2
SMG7
SMG7 nonsense mediated mRNA decay factor
chr19_+_984313 0.09 ENST00000251289.5
ENST00000587001.2
ENST00000607440.1
WDR18
WD repeat domain 18
chr11_-_71159458 0.09 ENST00000355527.3
DHCR7
7-dehydrocholesterol reductase
chr15_-_41408339 0.09 ENST00000401393.3
INO80
INO80 complex subunit
chr16_-_8962853 0.09 ENST00000565287.1
ENST00000311052.5
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr17_-_15902951 0.09 ENST00000472495.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr19_+_47759716 0.09 ENST00000221922.6
CCDC9
coiled-coil domain containing 9
chr17_-_1083078 0.09 ENST00000574266.1
ENST00000302538.5
ABR
active BCR-related
chr15_-_91565743 0.09 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr17_-_76124812 0.09 ENST00000592063.1
ENST00000589271.1
ENST00000322933.4
ENST00000589553.1
TMC6
transmembrane channel-like 6
chr10_-_23633720 0.09 ENST00000323327.4
C10orf67
chromosome 10 open reading frame 67
chr17_-_80291818 0.09 ENST00000269389.3
ENST00000581691.1
SECTM1
secreted and transmembrane 1
chr2_+_242255573 0.08 ENST00000420786.1
SEPT2
septin 2
chr22_-_31328881 0.08 ENST00000445980.1
MORC2
MORC family CW-type zinc finger 2
chr17_+_45331184 0.08 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
ITGB3
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr6_-_85473156 0.08 ENST00000606784.1
ENST00000606325.1
TBX18
T-box 18
chr11_-_34379546 0.08 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr16_+_4897912 0.08 ENST00000545171.1
UBN1
ubinuclein 1
chr16_+_30205754 0.08 ENST00000354723.6
ENST00000355544.5
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr2_+_79740118 0.08 ENST00000496558.1
ENST00000451966.1
CTNNA2
catenin (cadherin-associated protein), alpha 2
chr14_+_103243813 0.08 ENST00000560371.1
ENST00000347662.4
ENST00000392745.2
ENST00000539721.1
ENST00000560463.1
TRAF3
TNF receptor-associated factor 3
chr11_+_12696102 0.08 ENST00000527636.1
ENST00000527376.1
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr16_+_56623433 0.08 ENST00000570176.1
MT3
metallothionein 3
chr7_-_100808394 0.08 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr19_+_48949087 0.08 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr19_-_18385246 0.08 ENST00000608950.1
ENST00000600328.3
ENST00000600359.3
ENST00000392413.4
KIAA1683
KIAA1683
chr6_+_123317116 0.08 ENST00000275162.5
CLVS2
clavesin 2
chr16_+_2039946 0.08 ENST00000248121.2
ENST00000568896.1
SYNGR3
synaptogyrin 3
chr16_-_1993260 0.08 ENST00000361871.3
MSRB1
methionine sulfoxide reductase B1
chr19_-_48753028 0.08 ENST00000522431.1
CARD8
caspase recruitment domain family, member 8
chr9_+_132565418 0.08 ENST00000259339.2
TOR1B
torsin family 1, member B (torsin B)
chr7_-_150020750 0.08 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr7_+_75511362 0.08 ENST00000428119.1
RHBDD2
rhomboid domain containing 2
chr5_-_131563474 0.08 ENST00000417528.1
P4HA2
prolyl 4-hydroxylase, alpha polypeptide II
chr1_-_11751529 0.08 ENST00000376672.1
MAD2L2
MAD2 mitotic arrest deficient-like 2 (yeast)
chr14_+_64971438 0.08 ENST00000555321.1
ZBTB1
zinc finger and BTB domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC3_ZIC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0061743 motor learning(GO:0061743) maintenance of synapse structure(GO:0099558)
0.2 0.5 GO:0014054 positive regulation of gamma-aminobutyric acid secretion(GO:0014054)
0.2 1.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 0.7 GO:0010847 regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.1 0.4 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 0.4 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.3 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 0.3 GO:1990697 protein depalmitoleylation(GO:1990697)
0.1 0.7 GO:0070889 platelet alpha granule organization(GO:0070889)
0.1 0.2 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.1 0.3 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.3 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.2 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.3 GO:0015692 lead ion transport(GO:0015692)
0.0 0.2 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.0 0.5 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.1 GO:0061184 dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) positive regulation of dermatome development(GO:0061184)
0.0 0.2 GO:0042376 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0 0.1 GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.2 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.0 0.5 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.1 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.0 0.2 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0097212 cadmium ion homeostasis(GO:0055073) lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
0.0 0.1 GO:0090678 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.3 GO:0042756 drinking behavior(GO:0042756)
0.0 0.1 GO:0060434 bronchus morphogenesis(GO:0060434)
0.0 0.6 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.2 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.0 0.1 GO:0030822 positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.0 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0071224 cellular response to peptidoglycan(GO:0071224)
0.0 0.1 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.5 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.0 GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter(GO:0072365)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.0 0.0 GO:0044793 negative regulation by host of viral process(GO:0044793) negative regulation by host of viral genome replication(GO:0044828)
0.0 0.0 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.2 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 0.1 GO:2000857 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.1 GO:0006550 isoleucine catabolic process(GO:0006550)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.2 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.1 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0043405 regulation of MAP kinase activity(GO:0043405) positive regulation of MAP kinase activity(GO:0043406)
0.0 0.0 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.4 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.0 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.0 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.0 0.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.0 0.2 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.0 GO:0015882 L-ascorbic acid transport(GO:0015882) molecular hydrogen transport(GO:0015993) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0044301 climbing fiber(GO:0044301)
0.1 0.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.3 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 0.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.3 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.7 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.1 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.0 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.0 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.0 0.0 GO:0070703 inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.3 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.5 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.3 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.3 GO:0015639 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.1 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.0 0.1 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.3 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.0 GO:0036328 VEGF-C-activated receptor activity(GO:0036328)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.0 GO:0070890 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA