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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ZEB1
Z-value: 1.24
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31608054_31608156 | -0.73 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_62199427 Show fit | 1.44 |
ENST00000427522.2
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr12_+_56732658 Show fit | 0.98 |
ENST00000228534.4
|
interleukin 23, alpha subunit p19 |
|
| chr9_-_131940526 Show fit | 0.96 |
ENST00000372491.2
|
immediate early response 5-like |
|
| chr3_-_45187843 Show fit | 0.84 |
ENST00000296129.1
ENST00000425231.2 |
CUB domain containing protein 1 |
|
| chr17_+_68165657 Show fit | 0.76 |
ENST00000243457.3
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
|
| chr15_+_45722727 Show fit | 0.75 |
ENST00000396650.2
ENST00000558435.1 ENST00000344300.3 |
chromosome 15 open reading frame 48 |
|
| chr8_-_145060593 Show fit | 0.72 |
ENST00000313059.5
ENST00000524918.1 ENST00000313028.7 ENST00000525773.1 |
poly (ADP-ribose) polymerase family, member 10 |
|
| chr15_+_41221536 Show fit | 0.71 |
ENST00000249749.5
|
delta-like 4 (Drosophila) |
|
| chr19_+_39786962 Show fit | 0.69 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr3_-_49851313 Show fit | 0.64 |
ENST00000333486.3
|
ubiquitin-like modifier activating enzyme 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.2 | 1.4 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
| 0.2 | 1.1 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.2 | 1.1 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 1.1 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 1.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.9 | GO:0045079 | negative regulation of chemokine biosynthetic process(GO:0045079) |
| 0.1 | 0.9 | GO:0014041 | regulation of neuron maturation(GO:0014041) |
| 0.0 | 0.9 | GO:0006751 | glutathione catabolic process(GO:0006751) |
| 0.2 | 0.8 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 1.2 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 1.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 1.0 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.8 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 0.7 | GO:0032002 | interleukin-28 receptor complex(GO:0032002) |
| 0.1 | 0.6 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.0 | 0.6 | GO:0033391 | chromatoid body(GO:0033391) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.5 | 1.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.0 | 1.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 1.3 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.0 | 1.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 1.0 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 1.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.8 | GO:0005536 | glucose binding(GO:0005536) |
| 0.0 | 0.8 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.3 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.0 | 1.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.0 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.9 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 1.1 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 1.0 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 0.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.8 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.0 | 0.8 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.7 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |