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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for ZBTB33_CHD2
Z-value: 4.15
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93443419_93443580 | 0.92 | 8.1e-02 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | 0.78 | 2.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.7 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 7.1 | GO:0006879 | cellular iron ion homeostasis(GO:0006879) |
| 0.9 | 4.6 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.8 | 3.3 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168) |
| 0.2 | 3.3 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 1.1 | 3.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.1 | 2.8 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.2 | 2.7 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.1 | 2.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.3 | 2.6 | GO:0051418 | interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | GO:0016592 | mediator complex(GO:0016592) |
| 0.4 | 5.7 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 5.2 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 4.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 3.9 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 3.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 3.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 3.0 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.3 | 2.6 | GO:0000923 | equatorial microtubule organizing center(GO:0000923) |
| 0.1 | 2.5 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 4.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 1.4 | 4.2 | GO:0030626 | U12 snRNA binding(GO:0030626) |
| 0.0 | 3.9 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 3.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.8 | 3.2 | GO:1904455 | ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455) |
| 0.1 | 3.0 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 2.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 2.7 | GO:0004386 | helicase activity(GO:0004386) |
| 0.9 | 2.6 | GO:0030350 | iron-responsive element binding(GO:0030350) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 4.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 3.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 1.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 4.6 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 4.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 3.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 3.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 3.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.1 | 2.8 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 2.7 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.2 | 2.5 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |