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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for YY1_YY2
Z-value: 1.34
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Transcription factors associated with YY1_YY2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| YY1 | hg19_v2_chr14_+_100705322_100705360 | -0.57 | 4.3e-01 | Click! |
| YY2 | hg19_v2_chrX_+_21874105_21874105 | 0.05 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_26020672 Show fit | 1.14 |
ENST00000357647.3
|
histone cluster 1, H3a |
|
| chr20_-_62203808 Show fit | 1.11 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chrX_-_153236819 Show fit | 0.93 |
ENST00000354233.3
|
host cell factor C1 (VP16-accessory protein) |
|
| chrX_-_153237258 Show fit | 0.77 |
ENST00000310441.7
|
host cell factor C1 (VP16-accessory protein) |
|
| chr12_-_62653903 Show fit | 0.77 |
ENST00000552075.1
|
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 |
|
| chr1_+_153963227 Show fit | 0.71 |
ENST00000368567.4
ENST00000392558.4 |
ribosomal protein S27 |
|
| chr19_-_13044494 Show fit | 0.71 |
ENST00000593021.1
ENST00000587981.1 ENST00000423140.2 ENST00000314606.4 |
phenylalanyl-tRNA synthetase, alpha subunit |
|
| chr19_+_4791722 Show fit | 0.67 |
ENST00000269856.3
|
fem-1 homolog a (C. elegans) |
|
| chr19_-_5622991 Show fit | 0.67 |
ENST00000252542.4
|
scaffold attachment factor B2 |
|
| chrX_-_153236620 Show fit | 0.67 |
ENST00000369984.4
|
host cell factor C1 (VP16-accessory protein) |
Network of associatons between targets according to the STRING database.
First level regulatory network of YY1_YY2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 3.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.6 | 2.4 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.0 | 2.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.8 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 1.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 1.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 1.3 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.3 | 1.2 | GO:2000314 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 1.1 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 3.8 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 3.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 2.6 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.0 | 2.4 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.4 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.1 | 1.3 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 1.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.2 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 2.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 2.2 | GO:0043996 | histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972) |
| 0.0 | 2.1 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 2.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 1.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 1.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.3 | 1.3 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 1.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 1.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.2 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.2 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 3.9 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 3.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 3.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 1.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.1 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 1.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |