ISMARA results: YBX1_FOS_NFYC_NFYA_NFYB

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.80

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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Gene Symbol	Gene ID	Gene Info
YBX1 Ensembl NCBI GeneCards UniProt	ENSG00000065978.13	Y-box binding protein 1
FOS Ensembl NCBI GeneCards UniProt	ENSG00000170345.5	Fos proto-oncogene, AP-1 transcription factor subunit
NFYC Ensembl NCBI GeneCards UniProt	ENSG00000066136.15	nuclear transcription factor Y subunit gamma
NFYA Ensembl NCBI GeneCards UniProt	ENSG00000001167.10	nuclear transcription factor Y subunit alpha
NFYB Ensembl NCBI GeneCards UniProt	ENSG00000120837.3	nuclear transcription factor Y subunit beta
CEBPZ Ensembl NCBI GeneCards UniProt	ENSG00000115816.9	CCAAT enhancer binding protein zeta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFYC	hg19_v2_chr1_+_41157671_41157695	-0.98	1.5e-02	Click!
FOS	hg19_v2_chr14_+_75746664_75746683	0.93	7.1e-02	Click!
YBX1	hg19_v2_chr1_+_43148625_43148710	0.81	1.9e-01	Click!
NFYB	hg19_v2_chr12_-_104532062_104532071	0.72	2.8e-01	Click!
NFYA	hg19_v2_chr6_+_41040678_41040722	0.63	3.7e-01	Click!
CEBPZ	hg19_v2_chr2_-_37458749_37458856	0.38	6.2e-01	Click!

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_57233087 Show fit	5.20	ENST00000578777.1 ENST00000577457.1 ENST00000582995.1	PRR11 Ensembl NCBI GeneCards UniProt Show fit	proline rich 11
chr17_-_57232525 Show fit	5.13	ENST00000583380.1 ENST00000580541.1 ENST00000578105.1 ENST00000437036.2	SKA2 Ensembl NCBI GeneCards UniProt Show fit	spindle and kinetochore associated complex subunit 2
chr17_+_57232690 Show fit	4.21	ENST00000262293.4	PRR11 Ensembl NCBI GeneCards UniProt Show fit	proline rich 11
chr19_-_14247365 Show fit	4.00	ENST00000592798.1 ENST00000474890.1	ASF1B Ensembl NCBI GeneCards UniProt Show fit	anti-silencing function 1B histone chaperone
chr17_-_38574169 Show fit	3.48	ENST00000423485.1	TOP2A Ensembl NCBI GeneCards UniProt Show fit	topoisomerase (DNA) II alpha 170kDa
chr14_+_74551650 Show fit	3.28	ENST00000554938.1	LIN52 Ensembl NCBI GeneCards UniProt Show fit	lin-52 homolog (C. elegans)
chr17_-_57232596 Show fit	3.02	ENST00000581068.1 ENST00000330137.7	SKA2 Ensembl NCBI GeneCards UniProt Show fit	spindle and kinetochore associated complex subunit 2
chr1_-_197115818 Show fit	2.82	ENST00000367409.4 ENST00000294732.7	ASPM Ensembl NCBI GeneCards UniProt Show fit	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr19_+_45973120 Show fit	2.30	ENST00000592811.1 ENST00000586615.1	FOSB Ensembl NCBI GeneCards UniProt Show fit	FBJ murine osteosarcoma viral oncogene homolog B
chr14_-_100070363 Show fit	2.13	ENST00000380243.4	CCDC85C Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 85C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	8.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1	6.4	GO:0031110	regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1	5.9	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.4	4.2	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5	4.1	GO:0090166	Golgi disassembly(GO:0090166)
0.2	4.1	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.1	4.1	GO:0060122	inner ear receptor stereocilium organization(GO:0060122)
0.1	3.9	GO:0007077	mitotic nuclear envelope disassembly(GO:0007077)
0.0	3.7	GO:0035308	negative regulation of protein dephosphorylation(GO:0035308)
0.6	3.6	GO:0019470	4-hydroxyproline catabolic process(GO:0019470)

Showing 1 to 10 of 572 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	10.8	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	9.2	GO:0000922	spindle pole(GO:0000922)
0.0	6.6	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	5.9	GO:0005871	kinesin complex(GO:0005871)
1.1	5.4	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.5	5.1	GO:0072687	meiotic spindle(GO:0072687)
0.1	5.0	GO:0000786	nucleosome(GO:0000786)
0.1	4.4	GO:0005680	anaphase-promoting complex(GO:0005680)
0.2	3.9	GO:0000812	Swr1 complex(GO:0000812)
1.2	3.5	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)

Showing 1 to 10 of 225 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.4	GO:0042393	histone binding(GO:0042393)
0.0	8.4	GO:0015631	tubulin binding(GO:0015631)
0.1	5.7	GO:0003777	microtubule motor activity(GO:0003777)
0.1	5.0	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	4.4	GO:0003684	damaged DNA binding(GO:0003684)
0.0	3.9	GO:0031490	chromatin DNA binding(GO:0031490)
1.3	3.8	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1	3.8	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.1	3.6	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.2	3.5	GO:0043138	3'-5' DNA helicase activity(GO:0043138)

Showing 1 to 10 of 373 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	20.2	PID PLK1 PATHWAY	PLK1 signaling events
0.1	10.3	PID AURORA B PATHWAY	Aurora B signaling
0.1	8.6	PID FANCONI PATHWAY	Fanconi anemia pathway
0.1	7.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	7.0	PID P53 REGULATION PATHWAY	p53 pathway
0.1	6.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	3.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	3.1	PID AURORA A PATHWAY	Aurora A signaling
0.0	2.9	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Showing 1 to 10 of 59 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	25.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	6.2	REACTOME KINESINS	Genes involved in Kinesins
0.3	5.8	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1	5.0	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.2	4.6	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.1	4.5	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2	4.4	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	4.4	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	4.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1	4.1	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)

Showing 1 to 10 of 87 entries

Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 4.80

Motif logo

Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Activity-expression correlation:

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: