ISMARA results: WT1_MTF1

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for WT1_MTF1_ZBTB7B

Z-value: 3.26

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Transcription factors associated with WT1_MTF1_ZBTB7B

Gene Symbol	Gene ID	Gene Info
WT1 Ensembl NCBI GeneCards UniProt	ENSG00000184937.8	WT1 transcription factor
MTF1 Ensembl NCBI GeneCards UniProt	ENSG00000188786.9	metal regulatory transcription factor 1
ZBTB7B Ensembl NCBI GeneCards UniProt	ENSG00000160685.9	zinc finger and BTB domain containing 7B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ZBTB7B	hg19_v2_chr1_+_154975110_154975149	-0.78	2.2e-01	Click!
MTF1	hg19_v2_chr1_-_38325256_38325292	-0.72	2.8e-01	Click!
WT1	hg19_v2_chr11_-_32457075_32457095	0.58	4.2e-01	Click!

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_45267760 Show fit	5.84	ENST00000503771.1	TMEM158 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 158 (gene/pseudogene)
chr16_+_56642489 Show fit	4.95	ENST00000561491.1	MT2A Ensembl NCBI GeneCards UniProt Show fit	metallothionein 2A
chr16_-_11350036 Show fit	3.92	ENST00000332029.2	SOCS1 Ensembl NCBI GeneCards UniProt Show fit	suppressor of cytokine signaling 1
chr4_-_8873531 Show fit	3.76	ENST00000400677.3	HMX1 Ensembl NCBI GeneCards UniProt Show fit	H6 family homeobox 1
chr16_+_56642041 Show fit	3.72	ENST00000245185.5	MT2A Ensembl NCBI GeneCards UniProt Show fit	metallothionein 2A
chr16_-_89268070 Show fit	3.71	ENST00000562855.2	SLC22A31 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22, member 31
chr12_+_130822606 Show fit	3.40	ENST00000546060.1 ENST00000539400.1	PIWIL1 Ensembl NCBI GeneCards UniProt Show fit	piwi-like RNA-mediated gene silencing 1
chr1_+_3689325 Show fit	3.25	ENST00000444870.2 ENST00000452264.1	SMIM1 Ensembl NCBI GeneCards UniProt Show fit	small integral membrane protein 1 (Vel blood group)
chr19_+_10197463 Show fit	3.18	ENST00000590378.1 ENST00000397881.3	C19orf66 Ensembl NCBI GeneCards UniProt Show fit	chromosome 19 open reading frame 66
chr22_-_50970506 Show fit	3.18	ENST00000428989.2 ENST00000403326.1	ODF3B Ensembl NCBI GeneCards UniProt Show fit	outer dense fiber of sperm tails 3B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	8.7	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7	7.9	GO:0034465	response to carbon monoxide(GO:0034465)
0.4	7.3	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.3	7.2	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.6	6.2	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.0	5.9	GO:0030421	defecation(GO:0030421)
0.6	5.6	GO:0097039	protein linear polyubiquitination(GO:0097039)
1.8	5.4	GO:0071629	cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.4	5.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.4	4.9	GO:0021894	cerebral cortex GABAergic interneuron development(GO:0021894)

Showing 1 to 10 of 1,350 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.1	GO:0030426	growth cone(GO:0030426)
0.1	16.8	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.2	9.5	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	9.5	GO:0005667	transcription factor complex(GO:0005667)
0.1	8.3	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	8.3	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	8.1	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	7.2	GO:0031012	extracellular matrix(GO:0031012)
0.4	7.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	6.9	GO:0031965	nuclear membrane(GO:0031965)

Showing 1 to 10 of 434 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	10.7	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.7	9.9	GO:0046870	cadmium ion binding(GO:0046870)
0.1	8.7	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.3	8.6	GO:0019992	diacylglycerol binding(GO:0019992)
0.2	7.9	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.1	7.6	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.8	7.3	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.2	7.3	GO:0005326	neurotransmitter transporter activity(GO:0005326)
0.1	6.8	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.6	6.7	GO:0004645	phosphorylase activity(GO:0004645)

Showing 1 to 10 of 769 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	13.8	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	11.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	9.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	9.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	9.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	8.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	8.0	PID NOTCH PATHWAY	Notch signaling pathway
0.1	5.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	5.6	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	5.5	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans

Showing 1 to 10 of 107 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	14.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	10.0	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	9.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	9.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	8.8	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.2	8.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	8.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	7.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	6.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation

Showing 1 to 10 of 170 entries

Results for WT1_MTF1_ZBTB7B

Z-value: 3.26

Motif logo

Transcription factors associated with WT1_MTF1_ZBTB7B

Activity-expression correlation:

Activity profile of WT1_MTF1_ZBTB7B motif

Sorted Z-values of WT1_MTF1_ZBTB7B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of WT1_MTF1_ZBTB7B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: