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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for WRNIP1
Z-value: 1.56
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Transcription factors associated with WRNIP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| WRNIP1 | hg19_v2_chr6_+_2765595_2765797 | -0.21 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_60719213 Show fit | 1.86 |
ENST00000227880.3
|
solute carrier family 15 (oligopeptide transporter), member 3 |
|
| chr11_+_57310114 Show fit | 1.52 |
ENST00000527972.1
ENST00000399154.2 |
smoothelin-like 1 |
|
| chr6_+_29691056 Show fit | 1.42 |
ENST00000414333.1
ENST00000334668.4 ENST00000259951.7 |
major histocompatibility complex, class I, F |
|
| chr12_-_121477039 Show fit | 1.29 |
ENST00000257570.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr19_-_47128294 Show fit | 1.28 |
ENST00000596260.1
ENST00000597185.1 ENST00000598865.1 ENST00000594275.1 ENST00000291294.2 |
prostaglandin I2 (prostacyclin) receptor (IP) |
|
| chr15_+_89182156 Show fit | 1.27 |
ENST00000379224.5
|
interferon stimulated exonuclease gene 20kDa |
|
| chr12_-_121476959 Show fit | 1.24 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr19_+_39786962 Show fit | 1.21 |
ENST00000333625.2
|
interferon, lambda 1 |
|
| chr19_-_49371711 Show fit | 1.18 |
ENST00000355496.5
ENST00000263265.6 |
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 |
|
| chr19_+_51152702 Show fit | 1.05 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.0 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.0 | 5.5 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.4 | 3.7 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.6 | 3.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.1 | 3.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 3.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 2.8 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 2.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.3 | 2.2 | GO:0038195 | urokinase plasminogen activator signaling pathway(GO:0038195) |
| 0.1 | 2.1 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 5.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 3.6 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 3.2 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.4 | 3.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 3.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 3.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 2.9 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.0 | 2.9 | GO:0045211 | postsynaptic membrane(GO:0045211) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 6.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 4.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 4.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 4.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 3.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 3.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 3.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 3.2 | GO:0046979 | TAP2 binding(GO:0046979) |
| 1.0 | 3.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 6.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 5.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 3.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.1 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 2.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 2.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 2.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 2.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.1 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.0 | 4.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.3 | 3.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 3.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 3.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.2 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 2.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |