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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for TP53
Z-value: 1.58
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Transcription factors associated with TP53
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP53 | hg19_v2_chr17_-_7590745_7590856 | 0.89 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP53
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 2.2 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.1 | 1.5 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.3 | 1.4 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.0 | 1.4 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
| 0.3 | 1.3 | GO:0090285 | negative regulation of protein glycosylation in Golgi(GO:0090285) |
| 0.1 | 1.2 | GO:0010668 | ectodermal cell differentiation(GO:0010668) |
| 0.4 | 1.1 | GO:1904404 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
| 0.1 | 1.0 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) |
| 0.1 | 1.0 | GO:0002934 | desmosome organization(GO:0002934) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 1.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 1.4 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.2 | 1.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.3 | 0.8 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 0.8 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 0.7 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.0 | 1.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 1.5 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.4 | 1.1 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.0 | 1.1 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 1.0 | GO:0043140 | ATP-dependent 3'-5' DNA helicase activity(GO:0043140) |
| 0.3 | 0.9 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.1 | 0.9 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.9 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.2 | 0.8 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 1.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.0 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 0.8 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.3 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.0 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.9 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.9 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.8 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.8 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.0 | 0.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |