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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for TLX2
Z-value: 1.18
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Transcription factors associated with TLX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TLX2 | hg19_v2_chr2_+_74741569_74741620 | -0.78 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_90712520 Show fit | 1.21 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr20_+_3024266 Show fit | 0.96 |
ENST00000245983.2
ENST00000359100.2 ENST00000359987.1 |
gonadotropin-releasing hormone 2 |
|
| chr3_+_186330712 Show fit | 0.95 |
ENST00000411641.2
ENST00000273784.5 |
alpha-2-HS-glycoprotein |
|
| chr10_+_115312766 Show fit | 0.82 |
ENST00000351270.3
|
hyaluronan binding protein 2 |
|
| chr2_-_190445499 Show fit | 0.69 |
ENST00000261024.2
|
solute carrier family 40 (iron-regulated transporter), member 1 |
|
| chr20_-_25038804 Show fit | 0.68 |
ENST00000323482.4
|
acyl-CoA synthetase short-chain family member 1 |
|
| chr15_+_82555125 Show fit | 0.67 |
ENST00000566205.1
ENST00000339465.5 ENST00000569120.1 ENST00000566861.1 |
family with sequence similarity 154, member B |
|
| chr4_-_105416039 Show fit | 0.61 |
ENST00000394767.2
|
CXXC finger protein 4 |
|
| chr10_+_88718314 Show fit | 0.60 |
ENST00000348795.4
|
synuclein, gamma (breast cancer-specific protein 1) |
|
| chr6_-_138428613 Show fit | 0.58 |
ENST00000421351.3
|
PERP, TP53 apoptosis effector |
Network of associatons between targets according to the STRING database.
First level regulatory network of TLX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.0 | 1.1 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.9 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.1 | 0.8 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.1 | 0.8 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 0.8 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.0 | 0.8 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 0.7 | GO:0070839 | regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839) |
| 0.1 | 0.7 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 0.1 | 0.7 | GO:0021546 | rhombomere development(GO:0021546) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 0.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.4 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.0 | 0.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.4 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.0 | 0.4 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 0.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 0.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 0.8 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.0 | 0.8 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.1 | 0.7 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.1 | 0.7 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.0 | 0.7 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.6 | GO:0004057 | arginyltransferase activity(GO:0004057) |
| 0.0 | 0.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 1.1 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 1.0 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.6 | REACTOME MRNA CAPPING | Genes involved in mRNA Capping |
| 0.0 | 0.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.4 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |