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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for THRB

Z-value: 0.81

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536253_245363280.927.6e-02Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_32414059 2.09 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr10_+_62538248 0.99 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr20_+_3024266 0.97 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
GNRH2
gonadotropin-releasing hormone 2
chr10_+_62538089 0.77 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr15_-_35838348 0.68 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6
diphthamine biosynthesis 6
chr13_+_27844464 0.66 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr10_+_60145155 0.63 ENST00000373895.3
TFAM
transcription factor A, mitochondrial
chr2_+_200472779 0.59 ENST00000427045.1
ENST00000419243.1
AC093590.1
AC093590.1
chr9_-_139268068 0.58 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr17_-_73840614 0.55 ENST00000586108.1
UNC13D
unc-13 homolog D (C. elegans)
chr8_+_22102626 0.47 ENST00000519237.1
ENST00000397802.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr19_-_52643157 0.46 ENST00000597013.1
ENST00000600228.1
ENST00000596290.1
ZNF616
zinc finger protein 616
chr8_+_22102611 0.44 ENST00000306433.4
POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr11_-_45307817 0.38 ENST00000020926.3
SYT13
synaptotagmin XIII
chr8_-_131028782 0.36 ENST00000519020.1
FAM49B
family with sequence similarity 49, member B
chr17_+_1646130 0.34 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chrX_+_101854096 0.29 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr2_-_9563469 0.29 ENST00000484735.1
ENST00000456913.2
ITGB1BP1
integrin beta 1 binding protein 1
chr6_+_77484663 0.27 ENST00000607287.1
RP11-354K4.2
RP11-354K4.2
chr12_+_54378923 0.27 ENST00000303460.4
HOXC10
homeobox C10
chr17_-_73839792 0.26 ENST00000590762.1
UNC13D
unc-13 homolog D (C. elegans)
chr1_-_207224307 0.26 ENST00000315927.4
YOD1
YOD1 deubiquitinase
chr16_+_72088376 0.23 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr20_+_39969519 0.19 ENST00000373257.3
LPIN3
lipin 3
chr11_+_73498973 0.15 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr6_-_99842041 0.15 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr1_-_154164534 0.14 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr1_-_113498616 0.13 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr17_-_73840774 0.13 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr2_-_9563216 0.13 ENST00000467606.1
ENST00000494563.1
ENST00000460001.1
ITGB1BP1
integrin beta 1 binding protein 1
chr11_-_47399942 0.12 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_+_28174649 0.11 ENST00000301908.3
PNOC
prepronociceptin
chr10_+_123970670 0.09 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr8_-_124037890 0.09 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr11_+_5617976 0.09 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr1_+_32712815 0.09 ENST00000373582.3
FAM167B
family with sequence similarity 167, member B
chr17_-_73840415 0.09 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr11_-_64014379 0.08 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_102937869 0.07 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
PMPCB
peptidase (mitochondrial processing) beta
chr11_-_47400078 0.07 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr1_-_113498943 0.07 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr11_-_47400062 0.07 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr2_-_9563319 0.05 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr3_+_50606577 0.05 ENST00000434410.1
ENST00000232854.4
HEMK1
HemK methyltransferase family member 1
chr11_+_5617858 0.03 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr5_+_131746575 0.03 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr9_+_100069933 0.02 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chr11_+_46366918 0.02 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr11_+_46366799 0.01 ENST00000532868.2
DGKZ
diacylglycerol kinase, zeta
chr8_+_19674651 0.01 ENST00000397977.3
INTS10
integrator complex subunit 10

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0002432 granuloma formation(GO:0002432)
0.3 1.8 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.2 0.6 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.1 0.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1 0.2 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.1 0.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 0.3 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.7 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.6 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 0.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.4 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.3 GO:0002034 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) negative regulation of plasminogen activation(GO:0010757)
0.0 0.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.7 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0036502 Derlin-1-VIMP complex(GO:0036502)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 1.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.2 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 0.3 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.4 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.2 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.6 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 1.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation