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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for THRA_RXRB
Z-value: 2.20
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Transcription factors associated with THRA_RXRB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| THRA | hg19_v2_chr17_+_38219063_38219154 | 0.75 | 2.5e-01 | Click! |
| RXRB | hg19_v2_chr6_-_33168391_33168465 | -0.05 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of THRA_RXRB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 1.0 | 3.0 | GO:0060629 | meiotic DNA double-strand break formation(GO:0042138) regulation of homologous chromosome segregation(GO:0060629) |
| 0.1 | 2.0 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.2 | 1.9 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.2 | 1.9 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 1.8 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.4 | 1.5 | GO:1904106 | protein localization to microvillus(GO:1904106) |
| 0.1 | 1.5 | GO:0030238 | male sex determination(GO:0030238) |
| 0.1 | 1.4 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.0 | 1.4 | GO:0007035 | vacuolar acidification(GO:0007035) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.4 | 1.9 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.0 | 1.8 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 1.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.5 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 1.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 1.3 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.3 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 1.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.3 | 1.1 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | GO:0035591 | signaling adaptor activity(GO:0035591) |
| 0.0 | 2.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.5 | 1.9 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.2 | 1.9 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 1.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 1.5 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.0 | 1.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.4 | 1.3 | GO:0061629 | RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629) |
| 0.1 | 1.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.0 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 1.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.8 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 1.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.2 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 0.9 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 0.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 0.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.4 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 1.4 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 1.3 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |