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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for TEAD4
Z-value: 2.70
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Transcription factors associated with TEAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD4 | hg19_v2_chr12_+_3068466_3068496 | -0.43 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_113760098 Show fit | 3.76 |
ENST00000346342.3
ENST00000541084.1 ENST00000375581.3 |
coagulation factor VII (serum prothrombin conversion accelerator) |
|
| chr9_+_67968793 Show fit | 3.59 |
ENST00000417488.1
|
Protein LOC644249 |
|
| chr1_+_241695670 Show fit | 3.53 |
ENST00000366557.4
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr1_+_241695424 Show fit | 3.22 |
ENST00000366558.3
ENST00000366559.4 |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr4_-_110723335 Show fit | 3.08 |
ENST00000394634.2
|
complement factor I |
|
| chr4_-_110723134 Show fit | 2.76 |
ENST00000510800.1
ENST00000512148.1 |
complement factor I |
|
| chr2_-_44550441 Show fit | 2.32 |
ENST00000420756.1
ENST00000444696.1 |
prolyl endopeptidase-like |
|
| chr10_-_90712520 Show fit | 2.29 |
ENST00000224784.6
|
actin, alpha 2, smooth muscle, aorta |
|
| chr4_-_110723194 Show fit | 2.20 |
ENST00000394635.3
|
complement factor I |
|
| chr11_+_86502085 Show fit | 2.17 |
ENST00000527521.1
|
protease, serine, 23 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.0 | 6.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 1.3 | 3.8 | GO:1905225 | response to thyrotropin-releasing hormone(GO:1905225) |
| 0.1 | 3.4 | GO:0031639 | plasminogen activation(GO:0031639) |
| 0.7 | 2.8 | GO:0003330 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.2 | 2.8 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 2.5 | GO:0044331 | cell-cell adhesion mediated by cadherin(GO:0044331) |
| 0.5 | 2.3 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 0.0 | 2.3 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.4 | 1.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.2 | 3.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 3.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.4 | 2.3 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 1.9 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 1.8 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 1.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.8 | GO:0043679 | axon terminus(GO:0043679) |
| 0.3 | 1.6 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.6 | 6.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 5.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 2.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 2.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 2.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 1.8 | GO:0070728 | leucine binding(GO:0070728) |
| 0.1 | 1.8 | GO:0097371 | MDM2/MDM4 family protein binding(GO:0097371) |
| 0.1 | 1.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 1.6 | GO:0031013 | troponin I binding(GO:0031013) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.7 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 1.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.0 | 1.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.3 | 6.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 3.8 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.4 | 3.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 2.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 1.6 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.5 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.4 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 1.3 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |