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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TCF7L2

Z-value: 0.93

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Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
TCF7L2
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114710425_114710470-0.772.3e-01Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_63557309 1.13 ENST00000580513.1
AXIN2
axin 2
chr2_+_11679963 0.99 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_101380121 0.91 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr11_+_69455855 0.87 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr7_-_105926058 0.86 ENST00000417537.1
NAMPT
nicotinamide phosphoribosyltransferase
chr2_-_241195452 0.81 ENST00000457178.1
AC124861.1
AC124861.1
chr15_+_90744745 0.68 ENST00000558051.1
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr17_-_47308128 0.61 ENST00000413580.1
ENST00000511066.1
PHOSPHO1
phosphatase, orphan 1
chr14_-_61124977 0.55 ENST00000554986.1
SIX1
SIX homeobox 1
chr7_-_75452673 0.55 ENST00000416943.1
CCL24
chemokine (C-C motif) ligand 24
chr5_+_133450365 0.54 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr8_-_16859690 0.52 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr7_-_27219849 0.51 ENST00000396344.4
HOXA10
homeobox A10
chr12_+_54694979 0.46 ENST00000552848.1
COPZ1
coatomer protein complex, subunit zeta 1
chr1_-_110933663 0.42 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr14_-_94443105 0.42 ENST00000555019.1
ASB2
ankyrin repeat and SOCS box containing 2
chr13_+_76334795 0.40 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr5_+_102200948 0.38 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr17_-_47308100 0.38 ENST00000503902.1
ENST00000512250.1
PHOSPHO1
phosphatase, orphan 1
chr20_+_45947246 0.37 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr12_+_70760056 0.35 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr10_+_71561630 0.35 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr1_+_162351503 0.35 ENST00000458626.2
C1orf226
chromosome 1 open reading frame 226
chr1_-_110933611 0.35 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chrX_-_47004437 0.34 ENST00000276062.8
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr16_-_73082274 0.33 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr4_-_120243545 0.33 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr12_+_9066472 0.32 ENST00000538657.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr13_+_76334567 0.32 ENST00000321797.8
LMO7
LIM domain 7
chr16_+_50582222 0.31 ENST00000268459.3
NKD1
naked cuticle homolog 1 (Drosophila)
chr14_+_93118813 0.30 ENST00000556418.1
RIN3
Ras and Rab interactor 3
chr16_+_53407383 0.30 ENST00000566383.1
RP11-44F14.2
RP11-44F14.2
chr4_+_183065793 0.30 ENST00000512480.1
TENM3
teneurin transmembrane protein 3
chr17_-_56065540 0.29 ENST00000583932.1
VEZF1
vascular endothelial zinc finger 1
chr13_+_24144796 0.29 ENST00000403372.2
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr5_-_157002775 0.29 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr5_-_157002749 0.28 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr11_+_114128522 0.28 ENST00000535401.1
NNMT
nicotinamide N-methyltransferase
chr5_-_160973649 0.28 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr3_-_134093275 0.27 ENST00000513145.1
ENST00000422605.2
AMOTL2
angiomotin like 2
chr17_-_40169659 0.26 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr10_-_105677427 0.26 ENST00000369764.1
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr17_-_39093672 0.25 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr17_-_73389854 0.25 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
GRB2
growth factor receptor-bound protein 2
chr17_-_79919713 0.25 ENST00000425009.1
NOTUM
notum pectinacetylesterase homolog (Drosophila)
chr6_+_32146131 0.24 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr5_+_131593364 0.24 ENST00000253754.3
ENST00000379018.3
PDLIM4
PDZ and LIM domain 4
chr7_+_110731062 0.23 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
LRRN3
leucine rich repeat neuronal 3
chrX_-_47004878 0.23 ENST00000377811.3
NDUFB11
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr7_+_137761220 0.23 ENST00000242375.3
ENST00000438242.1
AKR1D1
aldo-keto reductase family 1, member D1
chr1_-_94079648 0.23 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr17_+_38673270 0.23 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr5_-_153857819 0.23 ENST00000231121.2
HAND1
heart and neural crest derivatives expressed 1
chr16_+_19222479 0.22 ENST00000568433.1
SYT17
synaptotagmin XVII
chr2_+_33701286 0.22 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_31477072 0.22 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr2_+_228678550 0.22 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr3_-_134093395 0.22 ENST00000249883.5
AMOTL2
angiomotin like 2
chr17_+_42923686 0.21 ENST00000591513.1
HIGD1B
HIG1 hypoxia inducible domain family, member 1B
chr7_+_150076406 0.21 ENST00000329630.5
ZNF775
zinc finger protein 775
chr10_-_75351088 0.21 ENST00000451492.1
ENST00000413442.1
USP54
ubiquitin specific peptidase 54
chr8_+_29952914 0.21 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr5_-_148930960 0.21 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr13_-_30160925 0.20 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chrX_-_10588459 0.20 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr5_+_102201430 0.20 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr11_+_65408273 0.20 ENST00000394227.3
SIPA1
signal-induced proliferation-associated 1
chr22_+_19950060 0.20 ENST00000449653.1
COMT
catechol-O-methyltransferase
chr17_+_70026795 0.20 ENST00000472655.2
ENST00000538810.1
RP11-84E24.3
long intergenic non-protein coding RNA 1152
chr6_+_35704855 0.20 ENST00000288065.2
ENST00000373866.3
ARMC12
armadillo repeat containing 12
chrX_-_10588595 0.19 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr5_-_58335281 0.19 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_137761199 0.19 ENST00000411726.2
AKR1D1
aldo-keto reductase family 1, member D1
chr14_-_23762777 0.19 ENST00000431326.2
HOMEZ
homeobox and leucine zipper encoding
chr7_+_137761167 0.19 ENST00000432161.1
AKR1D1
aldo-keto reductase family 1, member D1
chr12_-_109797249 0.19 ENST00000538041.1
RP11-256L11.1
RP11-256L11.1
chr7_-_148581360 0.19 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr17_+_38337491 0.18 ENST00000538981.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr17_-_73389737 0.18 ENST00000392563.1
GRB2
growth factor receptor-bound protein 2
chr7_-_25702669 0.18 ENST00000446840.1
AC003090.1
AC003090.1
chr7_+_80275953 0.18 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chrX_+_46937745 0.18 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
RGN
regucalcin
chr6_-_32145861 0.17 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr8_-_42234745 0.17 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr10_+_71561649 0.17 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr2_-_9143786 0.17 ENST00000462696.1
ENST00000305997.3
MBOAT2
membrane bound O-acyltransferase domain containing 2
chrX_-_100183894 0.16 ENST00000328526.5
ENST00000372956.2
XKRX
XK, Kell blood group complex subunit-related, X-linked
chr8_+_29953163 0.16 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr4_+_30721968 0.16 ENST00000361762.2
PCDH7
protocadherin 7
chr17_-_7297833 0.16 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr2_-_233641265 0.16 ENST00000438786.1
ENST00000409779.1
ENST00000233826.3
KCNJ13
potassium inwardly-rectifying channel, subfamily J, member 13
chr6_+_12717892 0.16 ENST00000379350.1
PHACTR1
phosphatase and actin regulator 1
chrX_+_69488174 0.16 ENST00000480877.2
ENST00000307959.8
ARR3
arrestin 3, retinal (X-arrestin)
chr3_+_57875711 0.15 ENST00000442599.2
SLMAP
sarcolemma associated protein
chr6_-_11779174 0.15 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr3_+_259218 0.15 ENST00000449294.2
CHL1
cell adhesion molecule L1-like
chr1_+_223101757 0.15 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr17_-_39646116 0.15 ENST00000328119.6
KRT36
keratin 36
chr4_-_69215699 0.15 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr12_-_130529501 0.14 ENST00000561864.1
ENST00000567788.1
RP11-474D1.4
RP11-474D1.3
RP11-474D1.4
RP11-474D1.3
chr22_+_41347363 0.14 ENST00000216225.8
RBX1
ring-box 1, E3 ubiquitin protein ligase
chr2_+_47168630 0.14 ENST00000263737.6
TTC7A
tetratricopeptide repeat domain 7A
chr7_-_27213893 0.14 ENST00000283921.4
HOXA10
homeobox A10
chr1_+_151138526 0.14 ENST00000368902.1
SCNM1
sodium channel modifier 1
chr12_+_31477250 0.14 ENST00000313737.4
AC024940.1
AC024940.1
chr1_+_180199393 0.14 ENST00000263726.2
LHX4
LIM homeobox 4
chr5_+_170846640 0.13 ENST00000274625.5
FGF18
fibroblast growth factor 18
chr6_-_135424186 0.13 ENST00000529882.1
HBS1L
HBS1-like (S. cerevisiae)
chr14_+_64565442 0.13 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr7_+_80275752 0.13 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chrX_-_32173579 0.13 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr2_-_121223697 0.12 ENST00000593290.1
FLJ14816
long intergenic non-protein coding RNA 1101
chrX_-_110655306 0.12 ENST00000371993.2
DCX
doublecortin
chr2_+_204732487 0.12 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr6_+_155538093 0.12 ENST00000462408.2
TIAM2
T-cell lymphoma invasion and metastasis 2
chr13_-_36429763 0.12 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr5_+_102201509 0.12 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr7_-_148581251 0.12 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr4_-_146859623 0.12 ENST00000379448.4
ENST00000513320.1
ZNF827
zinc finger protein 827
chr14_+_59100774 0.11 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr2_+_173724771 0.11 ENST00000538974.1
ENST00000540783.1
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr18_+_29769978 0.11 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr2_+_196440692 0.11 ENST00000458054.1
SLC39A10
solute carrier family 39 (zinc transporter), member 10
chr6_-_11779403 0.10 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr9_-_23826298 0.10 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr12_-_52779433 0.10 ENST00000257951.3
KRT84
keratin 84
chr9_-_98268883 0.10 ENST00000551630.1
ENST00000548420.1
PTCH1
patched 1
chr14_+_32798462 0.10 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr1_-_115053781 0.10 ENST00000358465.2
ENST00000369543.2
TRIM33
tripartite motif containing 33
chr19_-_44008863 0.10 ENST00000601646.1
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr7_-_111428957 0.10 ENST00000417165.1
DOCK4
dedicator of cytokinesis 4
chr8_+_32579341 0.10 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr15_+_81293254 0.10 ENST00000267984.2
MESDC1
mesoderm development candidate 1
chr2_+_201936458 0.10 ENST00000237889.4
NDUFB3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr3_+_174577070 0.10 ENST00000454872.1
NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr3_-_33686925 0.09 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr9_-_32635667 0.09 ENST00000242310.4
TAF1L
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
chr15_+_96897466 0.09 ENST00000558382.1
ENST00000558499.1
RP11-522B15.3
RP11-522B15.3
chr1_-_161993616 0.09 ENST00000294794.3
OLFML2B
olfactomedin-like 2B
chrX_-_122866874 0.09 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr3_-_79068138 0.09 ENST00000495273.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr22_+_29279552 0.09 ENST00000544604.2
ZNRF3
zinc and ring finger 3
chr5_-_16936340 0.09 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr2_-_171571077 0.08 ENST00000409786.1
AC007405.2
long intergenic non-protein coding RNA 1124
chr17_-_39222131 0.08 ENST00000394015.2
KRTAP2-4
keratin associated protein 2-4
chr5_+_175815732 0.08 ENST00000274787.2
HIGD2A
HIG1 hypoxia inducible domain family, member 2A
chr5_-_16742330 0.08 ENST00000505695.1
ENST00000427430.2
MYO10
myosin X
chr19_-_40791160 0.08 ENST00000358335.5
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr14_-_65785502 0.08 ENST00000553754.1
CTD-2509G16.5
CTD-2509G16.5
chr15_+_93447675 0.08 ENST00000536619.1
CHD2
chromodomain helicase DNA binding protein 2
chrX_+_2670066 0.08 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG
Xg blood group
chr7_-_16505440 0.08 ENST00000307068.4
SOSTDC1
sclerostin domain containing 1
chr5_+_66300464 0.08 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr4_-_85419603 0.08 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr10_+_114710425 0.08 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr6_-_112575912 0.07 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr16_+_72088376 0.07 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
HP
HPR
haptoglobin
haptoglobin-related protein
chr2_-_201936302 0.07 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr19_-_40791211 0.07 ENST00000579047.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr9_+_136399929 0.07 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr15_+_43985725 0.07 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr4_-_109090106 0.07 ENST00000379951.2
LEF1
lymphoid enhancer-binding factor 1
chr17_-_39211463 0.07 ENST00000542910.1
ENST00000398477.1
KRTAP2-2
keratin associated protein 2-2
chrX_-_19765692 0.07 ENST00000432234.1
SH3KBP1
SH3-domain kinase binding protein 1
chr2_+_177028805 0.07 ENST00000249440.3
HOXD3
homeobox D3
chrX_+_15525426 0.06 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr1_+_147013182 0.06 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr6_+_152130240 0.06 ENST00000427531.2
ESR1
estrogen receptor 1
chr2_+_220309379 0.06 ENST00000451076.1
SPEG
SPEG complex locus
chr5_-_135290705 0.06 ENST00000274507.1
LECT2
leukocyte cell-derived chemotaxin 2
chr12_+_9067123 0.06 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr13_+_76334498 0.06 ENST00000534657.1
LMO7
LIM domain 7
chr5_-_24645078 0.06 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chrX_+_100645812 0.06 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr11_+_124789146 0.06 ENST00000408930.5
HEPN1
hepatocellular carcinoma, down-regulated 1
chr5_+_112074029 0.06 ENST00000512211.2
APC
adenomatous polyposis coli
chr6_-_112575687 0.06 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
LAMA4
laminin, alpha 4
chrX_-_132091284 0.06 ENST00000370833.2
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr2_+_69240511 0.05 ENST00000409349.3
ANTXR1
anthrax toxin receptor 1
chr19_+_51628165 0.05 ENST00000250360.3
ENST00000440804.3
SIGLEC9
sialic acid binding Ig-like lectin 9
chr17_+_80416050 0.05 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr3_+_183353356 0.05 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr3_-_149375783 0.05 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1
WW domain containing transcription regulator 1
chr21_+_18811205 0.05 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr11_-_18063973 0.05 ENST00000528338.1
TPH1
tryptophan hydroxylase 1
chr18_+_46065570 0.05 ENST00000591412.1
CTIF
CBP80/20-dependent translation initiation factor
chr10_+_105005644 0.05 ENST00000441178.2
RP11-332O19.5
ribulose-5-phosphate-3-epimerase-like 1
chr6_-_112575758 0.05 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr14_+_23235886 0.05 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
OXA1L
oxidase (cytochrome c) assembly 1-like
chr10_+_114710516 0.05 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr17_+_80416482 0.04 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr13_+_102142296 0.04 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr1_+_61330931 0.04 ENST00000371191.1
NFIA
nuclear factor I/A
chr2_-_99871570 0.04 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr15_-_65670360 0.04 ENST00000327987.4
IGDCC3
immunoglobulin superfamily, DCC subclass, member 3
chr6_-_28220002 0.04 ENST00000377294.2
ZKSCAN4
zinc finger with KRAB and SCAN domains 4
chr10_-_61900762 0.03 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr12_-_133464151 0.03 ENST00000315585.7
ENST00000266880.7
ENST00000443047.2
ENST00000432561.2
ENST00000450056.2
CHFR
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr14_-_75179774 0.03 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr19_-_59031118 0.03 ENST00000600990.1
ZBTB45
zinc finger and BTB domain containing 45

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.3 0.8 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 0.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.6 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.7 GO:0018032 protein amidation(GO:0018032)
0.1 0.5 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 0.3 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.1 0.7 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.9 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:1990697 protein depalmitoleylation(GO:1990697)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.2 GO:0045360 interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 1.0 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.1 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 0.2 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.1 1.1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.3 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.4 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.2 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.2 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.2 GO:0050666 cellular response to phosphate starvation(GO:0016036) regulation of sulfur amino acid metabolic process(GO:0031335) positive regulation of sulfur amino acid metabolic process(GO:0031337) regulation of homocysteine metabolic process(GO:0050666) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.3 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.2 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.1 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.0 0.2 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.1 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.2 GO:0030336 negative regulation of cell migration(GO:0030336) negative regulation of locomotion(GO:0040013) negative regulation of cellular component movement(GO:0051271) negative regulation of cell motility(GO:2000146)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:1903613 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.7 GO:0060065 uterus development(GO:0060065)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.4 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.3 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0042427 serotonin biosynthetic process(GO:0042427)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 1.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 0.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 0.6 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.1 0.5 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 0.6 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
0.1 0.7 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.1 0.2 GO:1990699 palmitoleyl hydrolase activity(GO:1990699)
0.1 0.3 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.9 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0002046 opsin binding(GO:0002046)
0.0 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.9 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0001132 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.2 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.0 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling