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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TBX4

Z-value: 1.16

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Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 T-box transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX4hg19_v2_chr17_+_59529743_595297980.752.5e-01Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_167453493 2.05 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr1_-_11907829 1.93 ENST00000376480.3
NPPA
natriuretic peptide A
chr9_+_40028620 1.42 ENST00000426179.1
AL353791.1
AL353791.1
chr15_+_90319557 1.21 ENST00000341735.3
MESP2
mesoderm posterior 2 homolog (mouse)
chr11_+_86511569 1.16 ENST00000441050.1
PRSS23
protease, serine, 23
chr5_-_34043310 1.13 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr11_+_73358594 1.00 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_154377669 0.90 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr9_-_75567962 0.88 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_+_86511549 0.84 ENST00000533902.2
PRSS23
protease, serine, 23
chr5_+_82767487 0.83 ENST00000343200.5
ENST00000342785.4
VCAN
versican
chr14_+_75746664 0.82 ENST00000557139.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr3_+_167453026 0.79 ENST00000472941.1
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr14_+_75746781 0.74 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chrX_+_70443050 0.74 ENST00000361726.6
GJB1
gap junction protein, beta 1, 32kDa
chr5_-_74807418 0.66 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr5_+_74807581 0.65 ENST00000241436.4
ENST00000352007.5
POLK
polymerase (DNA directed) kappa
chr12_+_65672702 0.65 ENST00000538045.1
ENST00000535239.1
MSRB3
methionine sulfoxide reductase B3
chr3_+_142315225 0.64 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
PLS1
plastin 1
chr4_-_114682936 0.62 ENST00000454265.2
ENST00000429180.1
ENST00000418639.2
ENST00000394526.2
ENST00000296402.5
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr2_-_175869936 0.62 ENST00000409900.3
CHN1
chimerin 1
chr2_-_157189180 0.58 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr15_+_76016293 0.57 ENST00000332145.2
ODF3L1
outer dense fiber of sperm tails 3-like 1
chr14_+_75745477 0.57 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr4_+_140222609 0.56 ENST00000296543.5
ENST00000398947.1
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chrX_+_16804544 0.55 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr21_+_30502806 0.55 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr12_-_90024360 0.55 ENST00000393164.2
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr5_+_82767284 0.53 ENST00000265077.3
VCAN
versican
chrX_+_123095546 0.51 ENST00000371157.3
ENST00000371145.3
ENST00000371144.3
STAG2
stromal antigen 2
chr4_-_114682597 0.50 ENST00000394524.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr2_+_61108650 0.50 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr4_-_102268628 0.49 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_43864387 0.47 ENST00000282406.4
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr13_-_46543805 0.46 ENST00000378921.2
ZC3H13
zinc finger CCCH-type containing 13
chr11_+_64073699 0.46 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr17_-_74533734 0.46 ENST00000589342.1
CYGB
cytoglobin
chr8_+_87111059 0.43 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr2_-_37458749 0.43 ENST00000234170.5
CEBPZ
CCAAT/enhancer binding protein (C/EBP), zeta
chr7_+_107220660 0.43 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr18_-_59561417 0.42 ENST00000591306.1
RNF152
ring finger protein 152
chr1_+_95582881 0.41 ENST00000370203.4
ENST00000456991.1
TMEM56
transmembrane protein 56
chr15_-_83474806 0.41 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr14_+_53196872 0.40 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr20_-_22565101 0.39 ENST00000419308.2
FOXA2
forkhead box A2
chr2_+_29033682 0.39 ENST00000379579.4
ENST00000334056.5
ENST00000449210.1
SPDYA
speedy/RINGO cell cycle regulator family member A
chr14_+_90864504 0.38 ENST00000544280.2
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr11_+_61447845 0.36 ENST00000257215.5
DAGLA
diacylglycerol lipase, alpha
chr6_+_32132360 0.34 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr15_+_36994210 0.34 ENST00000562489.1
C15orf41
chromosome 15 open reading frame 41
chr5_-_60240858 0.34 ENST00000426742.2
ENST00000265038.5
ENST00000543101.1
ENST00000439176.1
ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8
chr17_+_35849937 0.33 ENST00000394389.4
DUSP14
dual specificity phosphatase 14
chr11_+_4116054 0.33 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr7_+_133261209 0.32 ENST00000545148.1
EXOC4
exocyst complex component 4
chr11_+_18343800 0.32 ENST00000453096.2
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr11_+_18344106 0.32 ENST00000534641.1
ENST00000525831.1
ENST00000265963.4
GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr2_-_111291587 0.32 ENST00000437167.1
RGPD6
RANBP2-like and GRIP domain containing 6
chr20_+_11898507 0.31 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr11_-_85779971 0.31 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr2_-_160473114 0.31 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr7_-_127032741 0.30 ENST00000393313.1
ENST00000265827.3
ENST00000434602.1
ZNF800
zinc finger protein 800
chr11_+_114271251 0.30 ENST00000375490.5
RBM7
RNA binding motif protein 7
chrX_+_123095860 0.29 ENST00000428941.1
STAG2
stromal antigen 2
chrX_+_123095890 0.29 ENST00000435215.1
STAG2
stromal antigen 2
chr5_+_56469843 0.29 ENST00000514387.2
GPBP1
GC-rich promoter binding protein 1
chr8_-_99954788 0.29 ENST00000523601.1
STK3
serine/threonine kinase 3
chr20_+_2517253 0.28 ENST00000358864.1
TMC2
transmembrane channel-like 2
chr4_+_57371509 0.27 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chr2_+_219472637 0.27 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr2_+_219472488 0.27 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chr6_-_13487784 0.26 ENST00000379287.3
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr10_-_16563870 0.26 ENST00000298943.3
C1QL3
complement component 1, q subcomponent-like 3
chr22_-_41215328 0.25 ENST00000434185.1
ENST00000435456.2
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr8_+_95907993 0.24 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr3_-_66551397 0.24 ENST00000383703.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr22_-_42342733 0.24 ENST00000402420.1
CENPM
centromere protein M
chr11_-_129062093 0.24 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr17_-_8066843 0.24 ENST00000404970.3
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr6_+_36646435 0.23 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr6_+_79577189 0.21 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr7_+_143013198 0.21 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr5_+_56469939 0.21 ENST00000506184.2
GPBP1
GC-rich promoter binding protein 1
chr12_+_57853918 0.21 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr4_-_146859787 0.21 ENST00000508784.1
ZNF827
zinc finger protein 827
chr3_+_142315294 0.20 ENST00000464320.1
PLS1
plastin 1
chrX_+_69642881 0.20 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
chr16_+_2587965 0.19 ENST00000342085.4
ENST00000566659.1
PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_+_67596310 0.19 ENST00000264010.4
ENST00000401394.1
CTCF
CCCTC-binding factor (zinc finger protein)
chr22_-_41215291 0.19 ENST00000542412.1
ENST00000544408.1
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr10_+_135050908 0.18 ENST00000325980.9
VENTX
VENT homeobox
chr8_+_123793633 0.18 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr12_+_50451331 0.18 ENST00000228468.4
ASIC1
acid-sensing (proton-gated) ion channel 1
chr5_+_68788594 0.18 ENST00000396442.2
ENST00000380766.2
OCLN
occludin
chr7_-_28220354 0.18 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr2_-_85895295 0.18 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr11_-_85430163 0.16 ENST00000529581.1
ENST00000533577.1
SYTL2
synaptotagmin-like 2
chr5_+_32712363 0.16 ENST00000507141.1
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_+_111749942 0.16 ENST00000260276.3
C11orf1
chromosome 11 open reading frame 1
chrM_+_10464 0.16 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr1_+_16062820 0.16 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr10_-_99531709 0.15 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr4_-_102268484 0.15 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_-_45603657 0.15 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr9_-_74980113 0.14 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr13_-_52027134 0.14 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr10_-_75226166 0.13 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr5_+_56469775 0.13 ENST00000424459.3
GPBP1
GC-rich promoter binding protein 1
chr8_-_101724989 0.13 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr14_+_67291158 0.13 ENST00000555456.1
GPHN
gephyrin
chr3_-_49459878 0.12 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
AMT
aminomethyltransferase
chr1_+_27113963 0.12 ENST00000430292.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr3_+_63805017 0.12 ENST00000295896.8
C3orf49
chromosome 3 open reading frame 49
chr15_+_91449971 0.12 ENST00000557865.1
MAN2A2
mannosidase, alpha, class 2A, member 2
chrX_-_133930285 0.12 ENST00000486347.1
ENST00000343004.5
FAM122B
family with sequence similarity 122B
chr6_+_30295036 0.12 ENST00000376659.5
ENST00000428555.1
TRIM39
tripartite motif containing 39
chr3_-_93747425 0.11 ENST00000315099.2
STX19
syntaxin 19
chr11_+_111750206 0.10 ENST00000530214.1
ENST00000530799.1
C11orf1
chromosome 11 open reading frame 1
chr3_-_52443799 0.10 ENST00000470173.1
ENST00000296288.5
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr10_+_7860460 0.10 ENST00000344293.5
TAF3
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr15_-_90294523 0.10 ENST00000300057.4
MESP1
mesoderm posterior 1 homolog (mouse)
chr4_-_102268708 0.09 ENST00000525819.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_114471972 0.09 ENST00000369559.4
ENST00000369554.2
HIPK1
homeodomain interacting protein kinase 1
chr15_+_76030311 0.09 ENST00000543887.1
AC019294.1
AC019294.1
chrX_+_47050798 0.09 ENST00000412206.1
ENST00000427561.1
UBA1
ubiquitin-like modifier activating enzyme 1
chrX_+_46771711 0.09 ENST00000424392.1
ENST00000397189.1
PHF16
jade family PHD finger 3
chr1_+_35734616 0.09 ENST00000441447.1
ZMYM4
zinc finger, MYM-type 4
chr2_+_61108771 0.09 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr7_-_27142290 0.08 ENST00000222718.5
HOXA2
homeobox A2
chr2_-_175870085 0.08 ENST00000409156.3
CHN1
chimerin 1
chr19_-_46526304 0.07 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr11_-_18343669 0.07 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
HPS5
Hermansky-Pudlak syndrome 5
chr11_-_85430204 0.07 ENST00000389958.3
ENST00000527794.1
SYTL2
synaptotagmin-like 2
chr16_+_2587998 0.07 ENST00000441549.3
ENST00000268673.7
PDPK1
3-phosphoinositide dependent protein kinase-1
chr2_+_37458928 0.07 ENST00000439218.1
ENST00000432075.1
NDUFAF7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr12_+_58148842 0.07 ENST00000266643.5
MARCH9
membrane-associated ring finger (C3HC4) 9
chr3_-_66551351 0.06 ENST00000273261.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr11_-_85430088 0.06 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chrX_+_46771848 0.06 ENST00000218343.4
PHF16
jade family PHD finger 3
chr11_+_114270752 0.06 ENST00000540163.1
RBM7
RNA binding motif protein 7
chr17_-_7232585 0.06 ENST00000571887.1
ENST00000315614.7
ENST00000399464.2
ENST00000570460.1
NEURL4
neuralized E3 ubiquitin protein ligase 4
chr1_+_27114589 0.05 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr11_-_5248294 0.05 ENST00000335295.4
HBB
hemoglobin, beta
chr2_+_11696464 0.05 ENST00000234142.5
GREB1
growth regulation by estrogen in breast cancer 1
chr14_+_23344345 0.04 ENST00000551466.1
LRP10
low density lipoprotein receptor-related protein 10
chr1_+_154378049 0.04 ENST00000512471.1
IL6R
interleukin 6 receptor
chr4_-_114682719 0.04 ENST00000394522.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr11_-_6502534 0.04 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
ARFIP2
ADP-ribosylation factor interacting protein 2
chr2_-_219925189 0.04 ENST00000295731.6
IHH
indian hedgehog
chr3_-_197024394 0.03 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1
discs, large homolog 1 (Drosophila)
chr2_+_172864490 0.02 ENST00000315796.4
METAP1D
methionyl aminopeptidase type 1D (mitochondrial)
chr13_+_115047097 0.02 ENST00000351487.5
UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr9_-_74979420 0.02 ENST00000343431.2
ENST00000376956.3
ZFAND5
zinc finger, AN1-type domain 5
chr12_-_120241187 0.02 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr22_+_40441456 0.02 ENST00000402203.1
TNRC6B
trinucleotide repeat containing 6B
chr2_+_103089756 0.01 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr2_+_37458776 0.01 ENST00000002125.4
ENST00000336237.6
ENST00000431821.1
NDUFAF7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr20_+_44657845 0.01 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chrM_+_10053 0.01 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chr1_+_27114418 0.01 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr2_-_160472952 0.00 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr7_+_27282319 0.00 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr8_+_56014949 0.00 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr16_-_2205352 0.00 ENST00000563192.1
RP11-304L19.5
RP11-304L19.5

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.2 0.9 GO:0002384 hepatic immune response(GO:0002384)
0.2 2.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.7 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.2 0.6 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 0.7 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.2 0.2 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1 0.9 GO:0061624 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1 0.4 GO:0043132 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) NAD transport(GO:0043132) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.8 GO:1902896 terminal web assembly(GO:1902896)
0.1 1.1 GO:0071638 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 0.4 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.4 GO:0046340 diacylglycerol catabolic process(GO:0046340) retrograde trans-synaptic signaling(GO:0098917)
0.1 1.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.3 GO:0060005 vestibular reflex(GO:0060005)
0.1 1.1 GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.1 0.5 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 1.4 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.5 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.1 0.3 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.1 0.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.6 GO:0030091 protein repair(GO:0030091)
0.0 0.3 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0 0.1 GO:0018315 molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.2 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.7 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.1 GO:0100012 negative regulation of mesodermal cell fate specification(GO:0042662) regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.2 GO:1903593 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.3 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.6 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.1 GO:0035283 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.3 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0002325 natural killer cell differentiation involved in immune response(GO:0002325) regulation of natural killer cell differentiation involved in immune response(GO:0032826) regulation of cytolysis in other organism(GO:0051710)
0.0 0.4 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.2 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 2.8 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 0.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.2 GO:0009880 embryonic pattern specification(GO:0009880)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.2 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.6 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.9 GO:0007602 phototransduction(GO:0007602)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.0 GO:0060032 notochord regression(GO:0060032)
0.0 0.3 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 GO:0035976 AP1 complex(GO:0035976)
0.2 0.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.8 GO:1990357 terminal web(GO:1990357)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.1 0.6 GO:0000439 core TFIIH complex(GO:0000439)
0.1 0.3 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 1.8 GO:0042629 mast cell granule(GO:0042629)
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0097486 multivesicular body lumen(GO:0097486)
0.0 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.3 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 1.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.4 GO:0043204 perikaryon(GO:0043204)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 1.4 GO:0005796 Golgi lumen(GO:0005796)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.4 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.7 GO:0097001 ceramide binding(GO:0097001)
0.1 0.5 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.1 0.9 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 0.3 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 0.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.2 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 1.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.7 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 0.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 1.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 2.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0 0.1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 0.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.3 GO:0017160 Ral GTPase binding(GO:0017160)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.9 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.1 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.9 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 2.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.4 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 0.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 1.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.0 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing