ISMARA results: TBX4

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TBX4

Z-value: 1.16

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Transcription factors associated with TBX4

Gene Symbol	Gene ID	Gene Info
TBX4 Ensembl NCBI GeneCards UniProt	ENSG00000121075.5	T-box transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX4	hg19_v2_chr17_+_59529743_59529798	0.75	2.5e-01	Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_167453493 Show fit	2.05	ENST00000295777.5 ENST00000472747.2	SERPINI1 Ensembl NCBI GeneCards UniProt Show fit	serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr1_-_11907829 Show fit	1.93	ENST00000376480.3	NPPA Ensembl NCBI GeneCards UniProt Show fit	natriuretic peptide A
chr9_+_40028620 Show fit	1.42	ENST00000426179.1	AL353791.1 Ensembl NCBI GeneCards UniProt Show fit	AL353791.1
chr15_+_90319557 Show fit	1.21	ENST00000341735.3	MESP2 Ensembl NCBI GeneCards UniProt Show fit	mesoderm posterior 2 homolog (mouse)
chr11_+_86511569 Show fit	1.16	ENST00000441050.1	PRSS23 Ensembl NCBI GeneCards UniProt Show fit	protease, serine, 23
chr5_-_34043310 Show fit	1.13	ENST00000231338.7	C1QTNF3 Ensembl NCBI GeneCards UniProt Show fit	C1q and tumor necrosis factor related protein 3
chr11_+_73358594 Show fit	1.00	ENST00000227214.6 ENST00000398494.4 ENST00000543085.1	PLEKHB1 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing, family B (evectins) member 1
chr1_+_154377669 Show fit	0.90	ENST00000368485.3 ENST00000344086.4	IL6R Ensembl NCBI GeneCards UniProt Show fit	interleukin 6 receptor
chr9_-_75567962 Show fit	0.88	ENST00000297785.3 ENST00000376939.1	ALDH1A1 Ensembl NCBI GeneCards UniProt Show fit	aldehyde dehydrogenase 1 family, member A1
chr11_+_86511549 Show fit	0.84	ENST00000533902.2	PRSS23 Ensembl NCBI GeneCards UniProt Show fit	protease, serine, 23

Showing 1 to 10 of 163 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0007422	peripheral nervous system development(GO:0007422)
0.2	2.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.4	1.9	GO:1902304	positive regulation of potassium ion export(GO:1902304)
0.1	1.4	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	1.2	GO:0009880	embryonic pattern specification(GO:0009880)
0.1	1.1	GO:0071638	adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1	1.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.1	1.1	GO:1902514	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.2	0.9	GO:0002384	hepatic immune response(GO:0002384)
0.1	0.9	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)

Showing 1 to 10 of 55 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	GO:0043204	perikaryon(GO:0043204)
0.2	2.1	GO:0035976	AP1 complex(GO:0035976)
0.0	1.8	GO:0042629	mast cell granule(GO:0042629)
0.0	1.4	GO:0005581	collagen trimer(GO:0005581)
0.0	1.4	GO:0005796	Golgi lumen(GO:0005796)
0.0	1.1	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.2	0.9	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.9	GO:0005955	calcineurin complex(GO:0005955)
0.1	0.8	GO:1990357	terminal web(GO:1990357)
0.0	0.7	GO:0005922	connexon complex(GO:0005922)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	2.1	GO:0070412	R-SMAD binding(GO:0070412)
0.1	1.9	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	1.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	1.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.3	0.9	GO:0070119	ciliary neurotrophic factor binding(GO:0070119)
0.1	0.9	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1	0.9	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	0.7	GO:0097001	ceramide binding(GO:0097001)
0.0	0.7	GO:0005243	gap junction channel activity(GO:0005243)

Showing 1 to 10 of 38 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	2.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	1.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	1.1	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.9	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.9	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Showing 1 to 10 of 11 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.9	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	1.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	1.4	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	1.0	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	0.9	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.9	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly

Showing 1 to 10 of 17 entries

Results for TBX4

Z-value: 1.16

Motif logo

Transcription factors associated with TBX4

Activity-expression correlation:

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: