ISMARA results: TBX1

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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for TBX1

Z-value: 1.87

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Transcription factors associated with TBX1

Gene Symbol	Gene ID	Gene Info
TBX1 Ensembl NCBI GeneCards UniProt	ENSG00000184058.8	T-box transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX1	hg19_v2_chr22_+_19744226_19744226	-0.81	1.9e-01	Click!

Activity profile of TBX1 motif

Sorted Z-values of TBX1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_219283815 Show fit	1.78	ENST00000248444.5 ENST00000454069.1 ENST00000392114.2	VIL1 Ensembl NCBI GeneCards UniProt Show fit	villin 1
chr9_+_139847347 Show fit	1.68	ENST00000371632.3	LCN12 Ensembl NCBI GeneCards UniProt Show fit	lipocalin 12
chr17_-_7080227 Show fit	1.56	ENST00000574330.1	ASGR1 Ensembl NCBI GeneCards UniProt Show fit	asialoglycoprotein receptor 1
chr20_-_44516256 Show fit	1.29	ENST00000372519.3	SPATA25 Ensembl NCBI GeneCards UniProt Show fit	spermatogenesis associated 25
chr12_+_102513950 Show fit	1.07	ENST00000378128.3 ENST00000327680.2 ENST00000541394.1 ENST00000543784.1	PARPBP Ensembl NCBI GeneCards UniProt Show fit	PARP1 binding protein
chr19_+_45973360 Show fit	1.07	ENST00000589593.1	FOSB Ensembl NCBI GeneCards UniProt Show fit	FBJ murine osteosarcoma viral oncogene homolog B
chr5_-_34043310 Show fit	1.05	ENST00000231338.7	C1QTNF3 Ensembl NCBI GeneCards UniProt Show fit	C1q and tumor necrosis factor related protein 3
chr17_+_4675175 Show fit	1.00	ENST00000270560.3	TM4SF5 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 4 L six family member 5
chr16_+_12059091 Show fit	0.99	ENST00000562385.1	TNFRSF17 Ensembl NCBI GeneCards UniProt Show fit	tumor necrosis factor receptor superfamily, member 17
chr9_-_34662651 Show fit	0.98	ENST00000259631.4	CCL27 Ensembl NCBI GeneCards UniProt Show fit	chemokine (C-C motif) ligand 27

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.8	GO:0051412	response to corticosterone(GO:0051412)
0.4	2.7	GO:1902896	terminal web assembly(GO:1902896)
0.0	2.2	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.1	2.0	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.0	1.8	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	1.7	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	1.7	GO:2000194	regulation of female gonad development(GO:2000194)
0.2	1.5	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	1.4	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.3	1.3	GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)

Showing 1 to 10 of 403 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0005871	kinesin complex(GO:0005871)
0.1	1.7	GO:0005577	fibrinogen complex(GO:0005577)
0.1	1.7	GO:0032433	filopodium tip(GO:0032433)
0.1	1.4	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	1.4	GO:0016328	lateral plasma membrane(GO:0016328)
0.2	1.3	GO:0031262	Ndc80 complex(GO:0031262)
0.1	1.3	GO:0034361	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1	1.2	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.2	0.9	GO:0034669	integrin alpha4-beta7 complex(GO:0034669)
0.1	0.9	GO:1990357	terminal web(GO:1990357)

Showing 1 to 10 of 144 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.4	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	2.2	GO:0051087	chaperone binding(GO:0051087)
0.2	1.8	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.0	1.7	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	1.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	1.4	GO:0003777	microtubule motor activity(GO:0003777)
0.0	1.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.2	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	1.2	GO:0001972	retinoic acid binding(GO:0001972)
0.1	1.1	GO:0004745	retinol dehydrogenase activity(GO:0004745)

Showing 1 to 10 of 251 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.0	PID AURORA B PATHWAY	Aurora B signaling
0.0	2.4	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	1.8	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	1.8	PID AURORA A PATHWAY	Aurora A signaling
0.0	1.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	1.1	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	2.5	REACTOME KINESINS	Genes involved in Kinesins
0.1	2.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	1.3	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	1.1	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	1.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	1.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	0.9	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.9	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines

Showing 1 to 10 of 58 entries

Results for TBX1

Z-value: 1.87

Motif logo

Transcription factors associated with TBX1

Activity-expression correlation:

Activity profile of TBX1 motif

Sorted Z-values of TBX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: