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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for TBP
Z-value: 3.24
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Transcription factors associated with TBP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBP | hg19_v2_chr6_+_170863421_170863484 | -0.83 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBP
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 1.6 | 6.3 | GO:2000110 | negative regulation of macrophage apoptotic process(GO:2000110) |
| 0.3 | 4.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 1.5 | 4.5 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.2 | 4.5 | GO:0002138 | retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102) |
| 0.0 | 4.4 | GO:0070268 | cornification(GO:0070268) |
| 0.1 | 4.1 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 1.0 | 3.8 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.6 | 3.5 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.1 | 3.5 | GO:0045907 | positive regulation of vasoconstriction(GO:0045907) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 5.5 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.1 | 4.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 3.9 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 3.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 3.5 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.8 | 3.2 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 3.0 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.0 | 2.9 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.8 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.9 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.7 | 4.9 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 4.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 4.1 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 4.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.2 | 4.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.3 | 3.8 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 3.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 3.4 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 3.3 | GO:0001618 | virus receptor activity(GO:0001618) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.3 | 3.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 3.3 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 3.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.4 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 2.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 1.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 7.0 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 5.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.7 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 2.9 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.8 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.0 | 2.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 2.6 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.2 | 2.0 | REACTOME DEFENSINS | Genes involved in Defensins |
| 0.1 | 1.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |