ISMARA results: STAT5A

Project

A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

Navigation

Downloads

Results for STAT5A

Z-value: 1.33

Motif logo

Transcription factors associated with STAT5A

Gene Symbol	Gene ID	Gene Info
STAT5A Ensembl NCBI GeneCards UniProt	ENSG00000126561.12	signal transducer and activator of transcription 5A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT5A	hg19_v2_chr17_+_40440481_40440561	-0.85	1.5e-01	Click!

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_148939598 Show fit	1.69	ENST00000455472.3	CP Ensembl NCBI GeneCards UniProt Show fit	ceruloplasmin (ferroxidase)
chr3_-_50649192 Show fit	1.40	ENST00000443053.2 ENST00000348721.3	CISH Ensembl NCBI GeneCards UniProt Show fit	cytokine inducible SH2-containing protein
chr1_-_230850043 Show fit	1.10	ENST00000366667.4	AGT Ensembl NCBI GeneCards UniProt Show fit	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_-_64216748 Show fit	1.04	ENST00000585162.1	APOH Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein H (beta-2-glycoprotein I)
chr7_+_142829162 Show fit	1.04	ENST00000291009.3	PIP Ensembl NCBI GeneCards UniProt Show fit	prolactin-induced protein
chr2_-_55237484 Show fit	0.92	ENST00000394609.2	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chr1_+_59486129 Show fit	0.83	ENST00000438195.1 ENST00000424308.1	RP4-794H19.4 Ensembl NCBI GeneCards UniProt Show fit	RP4-794H19.4
chr4_+_155484103 Show fit	0.83	ENST00000302068.4	FGB Ensembl NCBI GeneCards UniProt Show fit	fibrinogen beta chain
chr12_+_133657461 Show fit	0.81	ENST00000412146.2 ENST00000544426.1 ENST00000440984.2 ENST00000319849.3 ENST00000440550.2	ZNF140 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 140
chrY_+_15418467 Show fit	0.77	ENST00000595988.1	AC010877.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0006825	copper ion transport(GO:0006825)
0.1	1.9	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.3	1.4	GO:1903613	regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.4	1.1	GO:0061461	lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.0	1.1	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0	1.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.1	1.0	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	0.9	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.8	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1	0.8	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)

Showing 1 to 10 of 233 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	GO:0072562	blood microparticle(GO:0072562)
0.1	1.9	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	1.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.1	1.0	GO:0042627	chylomicron(GO:0042627)
0.1	0.9	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.2	0.8	GO:0042721	mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1	0.8	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.1	0.8	GO:0000796	condensin complex(GO:0000796)
0.0	0.8	GO:0005689	U12-type spliceosomal complex(GO:0005689)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0051087	chaperone binding(GO:0051087)
0.2	2.2	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	1.3	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	1.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.3	1.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	1.0	GO:0019864	IgG binding(GO:0019864)
0.0	0.8	GO:0051787	misfolded protein binding(GO:0051787)
0.1	0.7	GO:0034235	GPI anchor binding(GO:0034235)
0.1	0.6	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.1	0.6	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)

Showing 1 to 10 of 133 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	1.4	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	1.2	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	1.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.7	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.7	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.2	2.8	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	1.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	1.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.8	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.6	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.6	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.5	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.5	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation

Showing 1 to 10 of 33 entries

Results for STAT5A

Z-value: 1.33

Motif logo

Transcription factors associated with STAT5A

Activity-expression correlation:

Activity profile of STAT5A motif

Sorted Z-values of STAT5A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT5A

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: