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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for STAT4
Z-value: 1.65
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Transcription factors associated with STAT4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT4 | hg19_v2_chr2_-_192016316_192016325 | -0.86 | 1.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.2 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.4 | 2.3 | GO:0071727 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.7 | 2.2 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.7 | 2.0 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 2.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.4 | 1.8 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 1.3 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.0 | 1.3 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.0 | 1.2 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 1.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:0032059 | muscle thin filament tropomyosin(GO:0005862) bleb(GO:0032059) |
| 0.3 | 2.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 2.3 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.3 | 1.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.0 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.3 | 0.9 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.2 | 0.9 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.0 | 0.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 0.8 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.2 | 0.7 | GO:0043511 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 2.3 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.4 | 2.2 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 2.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 1.8 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 1.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.4 | 1.3 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 1.3 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.1 | 1.1 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.1 | 1.0 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.3 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.3 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 3.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 2.3 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 2.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 1.3 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 1.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 0.8 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 0.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |