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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SP4_PML
Z-value: 2.35
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP4 | hg19_v2_chr7_+_21467642_21467671 | 0.75 | 2.5e-01 | Click! |
| PML | hg19_v2_chr15_+_74287035_74287117 | -0.64 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_31381528 Show fit | 2.59 |
ENST00000339394.6
|
syndecan 3 |
|
| chr18_+_33161698 Show fit | 2.36 |
ENST00000591924.1
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) |
|
| chr20_+_33814457 Show fit | 1.95 |
ENST00000246186.6
|
matrix metallopeptidase 24 (membrane-inserted) |
|
| chr5_+_127419449 Show fit | 1.92 |
ENST00000262461.2
ENST00000343225.4 |
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
|
| chr14_-_100625932 Show fit | 1.80 |
ENST00000553834.1
|
delta(4)-desaturase, sphingolipid 2 |
|
| chr5_-_14871866 Show fit | 1.80 |
ENST00000284268.6
|
ANKH inorganic pyrophosphate transport regulator |
|
| chr3_+_23986748 Show fit | 1.75 |
ENST00000312521.4
|
nuclear receptor subfamily 1, group D, member 2 |
|
| chr14_-_100070363 Show fit | 1.75 |
ENST00000380243.4
|
coiled-coil domain containing 85C |
|
| chr5_+_92228 Show fit | 1.71 |
ENST00000512035.1
|
CTD-2231H16.1 |
|
| chr10_-_15413035 Show fit | 1.68 |
ENST00000378116.4
ENST00000455654.1 |
family with sequence similarity 171, member A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 4.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 3.7 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.4 | 3.6 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.1 | 3.6 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.1 | 3.4 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.2 | 3.1 | GO:0007379 | segment specification(GO:0007379) |
| 0.4 | 2.8 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 2.8 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.2 | 2.7 | GO:0071394 | cellular response to testosterone stimulus(GO:0071394) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 5.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 4.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 4.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 4.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 4.2 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 4.2 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 3.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 3.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 6.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 5.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 5.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 4.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 4.7 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 4.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 4.2 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 3.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 3.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 9.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 7.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 6.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 6.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 4.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 3.6 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 6.5 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 5.2 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 4.1 | REACTOME FGFR LIGAND BINDING AND ACTIVATION | Genes involved in FGFR ligand binding and activation |
| 0.1 | 4.0 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 3.5 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 3.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 3.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.2 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |