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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SP1
Z-value: 1.83
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53774423_53774658 | 0.63 | 3.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_96928516 Show fit | 0.85 |
ENST00000602703.1
|
RP11-2B6.3 |
|
| chr1_-_245026388 Show fit | 0.78 |
ENST00000440865.1
|
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
|
| chr8_-_99837856 Show fit | 0.74 |
ENST00000518165.1
ENST00000419617.2 |
serine/threonine kinase 3 |
|
| chr2_+_30369859 Show fit | 0.74 |
ENST00000402003.3
|
yippee-like 5 (Drosophila) |
|
| chr19_+_48112371 Show fit | 0.72 |
ENST00000594866.1
|
glioma tumor suppressor candidate region gene 1 |
|
| chr19_-_42759266 Show fit | 0.66 |
ENST00000594664.1
|
Uncharacterized protein |
|
| chr8_+_1711918 Show fit | 0.65 |
ENST00000331222.4
|
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) |
|
| chr11_+_65265141 Show fit | 0.65 |
ENST00000534336.1
|
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
|
| chr16_-_67427389 Show fit | 0.62 |
ENST00000562206.1
ENST00000290942.5 ENST00000393957.2 |
tubulin polymerization-promoting protein family member 3 |
|
| chr10_+_49514698 Show fit | 0.62 |
ENST00000432379.1
ENST00000429041.1 ENST00000374189.1 |
mitogen-activated protein kinase 8 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 2.1 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.2 | 1.9 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.1 | 1.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.0 | 1.6 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.0 | 1.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 1.5 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.0 | 1.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.3 | 1.4 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.6 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 1.6 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 1.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 1.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.2 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.2 | 1.1 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 3.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 2.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 1.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 1.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 1.5 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 1.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 1.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 1.3 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.1 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 4.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.4 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 2.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 2.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.9 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.6 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 3.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 2.1 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 1.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 1.9 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 1.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |