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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SOX21

Z-value: 0.78

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.425.8e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_42381173 0.62 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr12_+_1099675 0.47 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr19_+_42381337 0.46 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr7_-_107968999 0.42 ENST00000456431.1
NRCAM
neuronal cell adhesion molecule
chr18_-_47018869 0.42 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr15_-_80263506 0.36 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr2_-_241195452 0.34 ENST00000457178.1
AC124861.1
AC124861.1
chr1_+_67632083 0.33 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr11_+_35201826 0.32 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr1_-_169455169 0.32 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr12_-_89746264 0.32 ENST00000548755.1
DUSP6
dual specificity phosphatase 6
chr8_-_50466973 0.32 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr18_-_47018769 0.30 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr18_-_47018897 0.30 ENST00000418495.1
RPL17
ribosomal protein L17
chr12_-_1058849 0.30 ENST00000358495.3
RAD52
RAD52 homolog (S. cerevisiae)
chr7_-_86849836 0.29 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_+_221051699 0.29 ENST00000366903.6
HLX
H2.0-like homeobox
chr3_+_186288454 0.24 ENST00000265028.3
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr1_+_151171012 0.23 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr6_+_131958436 0.22 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr5_-_55529115 0.20 ENST00000513241.2
ENST00000341048.4
ANKRD55
ankyrin repeat domain 55
chr14_-_102771462 0.20 ENST00000522874.1
MOK
MOK protein kinase
chr6_+_131894284 0.20 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chrY_+_14813160 0.19 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr4_-_103746924 0.18 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103746683 0.17 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrX_-_131353461 0.17 ENST00000370874.1
RAP2C
RAP2C, member of RAS oncogene family
chrX_-_153210107 0.17 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP
renin binding protein
chr4_-_103747011 0.16 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr19_+_18682531 0.16 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chrX_-_55208866 0.16 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr5_-_95158644 0.16 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr12_+_59194154 0.15 ENST00000548969.1
RP11-362K2.2
Protein LOC100506869
chr14_+_64565442 0.14 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr19_-_45737469 0.14 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chr14_+_60712463 0.13 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr12_-_10324716 0.13 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr17_+_60457914 0.13 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr3_+_155838337 0.13 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr7_+_6713376 0.12 ENST00000399484.3
ENST00000544825.1
ENST00000401847.1
AC073343.1
Uncharacterized protein
chr19_-_2783255 0.11 ENST00000589251.1
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chrX_-_138724677 0.11 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr5_+_175875349 0.11 ENST00000261942.6
FAF2
Fas associated factor family member 2
chr10_-_12084770 0.10 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr14_+_95048217 0.10 ENST00000557598.1
ENST00000556064.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr5_-_95158375 0.09 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr5_-_61031495 0.09 ENST00000506550.1
ENST00000512882.2
CTD-2170G1.2
CTD-2170G1.2
chr5_-_124084493 0.08 ENST00000509799.1
ZNF608
zinc finger protein 608
chr6_-_52926539 0.08 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr15_+_58702742 0.08 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr4_-_122854193 0.07 ENST00000513531.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr11_+_2482661 0.07 ENST00000335475.5
KCNQ1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr5_-_179045199 0.07 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr11_-_57479673 0.07 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chr6_+_42531798 0.07 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chrX_+_36053908 0.06 ENST00000378660.2
CHDC2
calponin homology domain containing 2
chr4_-_39034542 0.06 ENST00000344606.6
TMEM156
transmembrane protein 156
chr4_-_177190364 0.06 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr7_-_107968921 0.06 ENST00000442580.1
NRCAM
neuronal cell adhesion molecule
chr4_+_81951957 0.06 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr14_-_92588246 0.06 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr14_+_50291993 0.06 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr7_+_120702819 0.05 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr14_+_101361107 0.05 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chrX_+_65384052 0.05 ENST00000336279.5
ENST00000458621.1
HEPH
hephaestin
chr14_-_95922526 0.05 ENST00000554873.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chr3_+_37035289 0.05 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr20_+_43343886 0.05 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr7_-_37026108 0.05 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr4_+_75174204 0.05 ENST00000332112.4
ENST00000514968.1
ENST00000503098.1
ENST00000502358.1
ENST00000509145.1
ENST00000505212.1
EPGN
epithelial mitogen
chr10_-_61495760 0.04 ENST00000395347.1
SLC16A9
solute carrier family 16, member 9
chr6_-_3195981 0.04 ENST00000425384.2
ENST00000435043.2
RP1-40E16.9
RP1-40E16.9
chr4_-_69083720 0.04 ENST00000432593.3
TMPRSS11BNL
TMPRSS11B N-terminal like
chr7_-_14942944 0.04 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chrX_+_52927576 0.04 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr12_+_101673872 0.03 ENST00000261637.4
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr18_+_29769978 0.03 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr16_-_15149828 0.03 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr4_+_75174180 0.03 ENST00000413830.1
EPGN
epithelial mitogen
chr12_-_89746173 0.02 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr8_-_19459993 0.02 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chrX_-_71792477 0.02 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
HDAC8
histone deacetylase 8
chr12_-_1058685 0.01 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52
RAD52 homolog (S. cerevisiae)
chr3_+_38537763 0.01 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr9_+_99690592 0.01 ENST00000354649.3
NUTM2G
NUT family member 2G
chr7_-_73133959 0.01 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr14_-_38028689 0.01 ENST00000553425.1
RP11-356O9.2
RP11-356O9.2
chr5_+_140579162 0.01 ENST00000536699.1
ENST00000354757.3
PCDHB11
protocadherin beta 11
chr4_-_122854612 0.01 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr6_-_121655850 0.00 ENST00000422369.1
TBC1D32
TBC1 domain family, member 32
chr8_+_101170563 0.00 ENST00000520508.1
ENST00000388798.2
SPAG1
sperm associated antigen 1
chr8_-_94029882 0.00 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chr17_-_65235916 0.00 ENST00000579861.1
HELZ
helicase with zinc finger
chr6_-_112575758 0.00 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr7_+_34697973 0.00 ENST00000381539.3
NPSR1
neuropeptide S receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.3 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.2 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.3 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.2 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.3 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627) negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.5 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.5 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.1 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.1 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 0.0 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.7 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.0 0.0 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.3 GO:0045838 positive regulation of membrane potential(GO:0045838)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.3 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0097181 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 0.0 GO:0005715 late recombination nodule(GO:0005715)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.3 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.1 0.2 GO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811)
0.0 0.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.3 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.4 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.7 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins