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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SMAD1
Z-value: 2.18
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402843_146402864 | -0.74 | 2.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | GO:0071357 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.4 | 3.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.3 | 3.0 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 0.2 | 2.8 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 2.6 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.0 | 2.6 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 2.4 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.0 | 2.3 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.4 | 2.1 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.3 | 2.1 | GO:0061143 | alveolar primary septum development(GO:0061143) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 3.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 2.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 2.4 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 2.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 2.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 2.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.9 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 1.8 | GO:0097342 | ripoptosome(GO:0097342) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.0 | 7.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 2.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 2.8 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 2.8 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 2.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 2.3 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.7 | 2.1 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 0.1 | 2.0 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 1.9 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.8 | PID TXA2PATHWAY | Thromboxane A2 receptor signaling |
| 0.0 | 2.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 2.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 1.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 16.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 4.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 3.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 3.6 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.3 | 3.3 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 2.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 2.5 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |