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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SIX6
Z-value: 1.11
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Transcription factors associated with SIX6
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_91061712 Show fit | 2.89 |
ENST00000371826.3
|
interferon-induced protein with tetratricopeptide repeats 2 |
|
| chr12_-_121477039 Show fit | 2.69 |
ENST00000257570.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr12_-_121476959 Show fit | 2.49 |
ENST00000339275.5
|
2'-5'-oligoadenylate synthetase-like |
|
| chr6_+_71104588 Show fit | 1.77 |
ENST00000418403.1
|
RP11-462G2.1 |
|
| chr11_-_104916034 Show fit | 1.50 |
ENST00000528513.1
ENST00000375706.2 ENST00000375704.3 |
caspase recruitment domain family, member 16 |
|
| chr12_-_121476750 Show fit | 1.27 |
ENST00000543677.1
|
2'-5'-oligoadenylate synthetase-like |
|
| chr8_-_128231299 Show fit | 0.97 |
ENST00000500112.1
|
colon cancer associated transcript 1 (non-protein coding) |
|
| chr15_-_80263506 Show fit | 0.94 |
ENST00000335661.6
|
BCL2-related protein A1 |
|
| chr11_-_104972158 Show fit | 0.86 |
ENST00000598974.1
ENST00000593315.1 ENST00000594519.1 ENST00000415981.2 ENST00000525374.1 ENST00000375707.1 |
caspase 1, apoptosis-related cysteine peptidase caspase recruitment domain family, member 16 caspase recruitment domain family, member 17 |
|
| chr6_+_37012607 Show fit | 0.81 |
ENST00000423336.1
|
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 2.9 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.3 | 2.4 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.0 | 0.9 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.2 | 0.7 | GO:0061580 | colon epithelial cell migration(GO:0061580) |
| 0.1 | 0.6 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.0 | 0.6 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.0 | 0.5 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.0 | 0.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 0.3 | GO:0070638 | nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.4 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 0.7 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.6 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.5 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.1 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.0 | 0.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 0.1 | GO:0005579 | membrane attack complex(GO:0005579) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 2.4 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.9 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.2 | 0.7 | GO:0003943 | N-acetylgalactosamine-4-sulfatase activity(GO:0003943) |
| 0.0 | 0.6 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.6 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.3 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.1 | 0.3 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 0.3 | GO:0015403 | thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.1 | 0.2 | GO:0015254 | pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254) urea channel activity(GO:0015265) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 0.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.7 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.2 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 0.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |