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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for SIX6

Z-value: 1.11

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
ENSG00000184302.6 SIX homeobox 6

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_91061712 2.89 ENST00000371826.3
interferon-induced protein with tetratricopeptide repeats 2
chr12_-_121477039 2.69 ENST00000257570.5
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 2.49 ENST00000339275.5
2'-5'-oligoadenylate synthetase-like
chr6_+_71104588 1.77 ENST00000418403.1
RP11-462G2.1
chr11_-_104916034 1.50 ENST00000528513.1
ENST00000375706.2
ENST00000375704.3
caspase recruitment domain family, member 16
chr12_-_121476750 1.27 ENST00000543677.1
2'-5'-oligoadenylate synthetase-like
chr8_-_128231299 0.97 ENST00000500112.1
colon cancer associated transcript 1 (non-protein coding)
chr15_-_80263506 0.94 ENST00000335661.6
BCL2-related protein A1
chr11_-_104972158 0.86 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr6_+_37012607 0.81 ENST00000423336.1
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr5_-_78281775 0.73 ENST00000396151.3
ENST00000565165.1
arylsulfatase B
chr22_+_24666763 0.72 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
sperm antigen with calponin homology and coiled-coil domains 1-like
chr4_-_71532601 0.62 ENST00000510614.1
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_+_189321881 0.56 ENST00000512839.1
ENST00000513313.1
long intergenic non-protein coding RNA 1060
chr19_-_53426700 0.56 ENST00000596623.1
zinc finger protein 888
chr6_-_26043885 0.52 ENST00000357905.2
histone cluster 1, H2bb
chr4_-_184241927 0.51 ENST00000323319.5
claudin 22
chr4_+_74301880 0.48 ENST00000395792.2
ENST00000226359.2
alpha-fetoprotein
chr1_-_65468148 0.42 ENST00000415842.1
RP11-182I10.3
chr14_-_46185155 0.40 ENST00000555442.1
RP11-369C8.1
chr21_-_43735628 0.35 ENST00000291525.10
ENST00000518498.1
trefoil factor 3 (intestinal)
chr5_-_177207634 0.35 ENST00000513554.1
ENST00000440605.3
family with sequence similarity 153, member A
chr2_-_100925967 0.35 ENST00000409647.1
LON peptidase N-terminal domain and ring finger 2
chr8_-_124553437 0.34 ENST00000517956.1
ENST00000443022.2
F-box protein 32
chr5_+_175490540 0.32 ENST00000515817.1
family with sequence similarity 153, member B
chr2_+_62132800 0.32 ENST00000538736.1
copper metabolism (Murr1) domain containing 1
chr1_-_161015752 0.32 ENST00000435396.1
ENST00000368021.3
upstream transcription factor 1
chr8_+_1993152 0.31 ENST00000262113.4
myomesin 2
chr14_+_20937538 0.29 ENST00000361505.5
ENST00000553591.1
purine nucleoside phosphorylase
chrX_-_77225135 0.29 ENST00000458128.1
phosphoglycerate mutase family member 4
chr17_+_61271355 0.29 ENST00000583356.1
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr2_+_62132781 0.27 ENST00000311832.5
copper metabolism (Murr1) domain containing 1
chr9_-_67786624 0.27 ENST00000455764.2
family with sequence similarity 27, member E3
chr2_-_228497888 0.27 ENST00000264387.4
ENST00000409066.1
chromosome 2 open reading frame 83
chr11_+_74699703 0.26 ENST00000529024.1
ENST00000544263.1
sialidase 3 (membrane sialidase)
chr2_+_85822857 0.25 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
ring finger protein 181
chr8_+_1993173 0.25 ENST00000523438.1
myomesin 2
chr12_+_40787194 0.25 ENST00000425730.2
ENST00000454784.4
mucin 19, oligomeric
chr1_-_157014865 0.25 ENST00000361409.2
Rho guanine nucleotide exchange factor (GEF) 11
chr3_+_151531859 0.25 ENST00000488869.1
arylacetamide deacetylase
chr2_-_239140011 0.24 ENST00000409376.1
ENST00000409070.1
ENST00000409942.1
Protein LOC151174
chr11_+_122709200 0.24 ENST00000227348.4
cytotoxic and regulatory T cell molecule
chr16_+_28648975 0.24 ENST00000529716.1
nuclear pore complex interacting protein family, member B8
chr16_-_29517141 0.24 ENST00000550665.1
Uncharacterized protein
chr12_+_119616447 0.24 ENST00000281938.2
heat shock 22kDa protein 8
chr6_+_127898312 0.23 ENST00000329722.7
chromosome 6 open reading frame 58
chr17_+_60501228 0.23 ENST00000311506.5
methyltransferase like 2A
chr19_-_44031375 0.23 ENST00000292147.2
ethylmalonic encephalopathy 1
chr4_-_71532668 0.23 ENST00000510437.1
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr4_+_74347400 0.23 ENST00000226355.3
afamin
chr2_+_210636697 0.22 ENST00000439458.1
ENST00000272845.6
unc-80 homolog (C. elegans)
chr18_+_50278430 0.22 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
deleted in colorectal carcinoma
chr18_+_55018044 0.21 ENST00000324000.3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_-_150669604 0.21 ENST00000427665.1
ENST00000540514.1
golgi phosphoprotein 3-like
chr1_+_160709055 0.21 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAM family member 7
chr9_-_100684845 0.21 ENST00000375119.3
chromosome 9 open reading frame 156
chr10_-_79397479 0.20 ENST00000404771.3
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr3_+_259218 0.20 ENST00000449294.2
cell adhesion molecule L1-like
chr10_-_61720640 0.19 ENST00000521074.1
ENST00000444900.1
chromosome 10 open reading frame 40
chr16_-_21436459 0.19 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
nuclear pore complex interacting protein family, member B3
chr16_+_22524844 0.19 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
nuclear pore complex interacting protein family, member B5
chr16_-_21868978 0.19 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
nuclear pore complex interacting protein family, member B4
chr22_-_17302589 0.18 ENST00000331428.5
XK, Kell blood group complex subunit-related family, member 3
chr8_+_67104323 0.18 ENST00000518412.1
ENST00000518035.1
ENST00000517725.1
long intergenic non-protein coding RNA 967
chr3_-_111314230 0.17 ENST00000317012.4
zinc finger, BED-type containing 2
chr16_-_87350970 0.16 ENST00000567970.1
chromosome 16 open reading frame 95
chrX_-_55020511 0.16 ENST00000375006.3
ENST00000374992.2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_+_58430567 0.16 ENST00000536493.1
aquaporin 9
chr5_+_55147205 0.15 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
interleukin 31 receptor A
chr16_-_21868739 0.15 ENST00000415645.2
nuclear pore complex interacting protein family, member B4
chr12_-_14849470 0.15 ENST00000261170.3
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr9_+_93759317 0.14 ENST00000563268.1
RP11-367F23.2
chr16_+_21689835 0.14 ENST00000286149.4
ENST00000388958.3
otoancorin
chr1_-_159684371 0.14 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
C-reactive protein, pentraxin-related
chr12_+_117348742 0.14 ENST00000309909.5
ENST00000455858.2
F-box and WD repeat domain containing 8
chr8_+_26247878 0.14 ENST00000518611.1
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr2_+_181988560 0.13 ENST00000424170.1
ENST00000435411.1
AC104820.2
chr1_+_160709076 0.13 ENST00000359331.4
ENST00000495334.1
SLAM family member 7
chr9_-_23821842 0.13 ENST00000544538.1
ELAV like neuron-specific RNA binding protein 2
chr1_+_31885963 0.13 ENST00000373709.3
serine incorporator 2
chr7_-_141957847 0.12 ENST00000552471.1
ENST00000547058.2
protease, serine, 58
chr2_-_100939195 0.11 ENST00000393437.3
LON peptidase N-terminal domain and ring finger 2
chr8_+_12809531 0.11 ENST00000532376.2
KIAA1456
chr9_-_135230336 0.11 ENST00000224140.5
ENST00000372169.2
ENST00000393220.1
senataxin
chr7_+_107332334 0.11 ENST00000541474.1
ENST00000544569.1
solute carrier family 26 (anion exchanger), member 4
chr9_-_7800067 0.10 ENST00000358227.4
transmembrane protein 261
chr8_+_24241789 0.10 ENST00000256412.4
ENST00000538205.1
ADAM-like, decysin 1
chr3_-_107596910 0.10 ENST00000464359.2
ENST00000464823.1
ENST00000466155.1
ENST00000473528.2
ENST00000608306.1
ENST00000488852.1
ENST00000608137.1
ENST00000608307.1
ENST00000609429.1
ENST00000601385.1
ENST00000475362.1
ENST00000600240.1
ENST00000600749.1
long intergenic non-protein coding RNA 635
chr2_-_238305397 0.10 ENST00000409809.1
collagen, type VI, alpha 3
chr20_+_54987305 0.10 ENST00000371336.3
ENST00000434344.1
Cas scaffolding protein family member 4
chr8_+_67405438 0.09 ENST00000305454.3
chromosome 8 open reading frame 46
chr15_+_58430368 0.08 ENST00000558772.1
ENST00000219919.4
aquaporin 9
chr1_+_112016414 0.08 ENST00000343534.5
ENST00000369718.3
chromosome 1 open reading frame 162
chr1_+_63063152 0.08 ENST00000371129.3
angiopoietin-like 3
chr8_-_110660975 0.08 ENST00000528045.1
syntabulin (syntaxin-interacting)
chr22_+_18043133 0.08 ENST00000327451.6
ENST00000399813.1
solute carrier family 25 (glutamate carrier), member 18
chr17_-_42327236 0.08 ENST00000399246.2
AC003102.1
chr12_-_78934441 0.07 ENST00000546865.1
ENST00000547089.1
RP11-171L9.1
chr2_-_77749387 0.07 ENST00000409884.1
leucine rich repeat transmembrane neuronal 4
chr8_+_24241969 0.07 ENST00000522298.1
ADAM-like, decysin 1
chr3_+_141457030 0.07 ENST00000273480.3
ring finger protein 7
chr5_+_40909354 0.07 ENST00000313164.9
complement component 7
chr1_+_160709029 0.07 ENST00000444090.2
ENST00000441662.2
SLAM family member 7
chr8_+_32579341 0.06 ENST00000519240.1
ENST00000539990.1
neuregulin 1
chr4_-_13546632 0.06 ENST00000382438.5
NK3 homeobox 2
chr2_-_77749336 0.06 ENST00000409282.1
leucine rich repeat transmembrane neuronal 4
chr11_+_124789146 0.06 ENST00000408930.5
hepatocellular carcinoma, down-regulated 1
chr12_-_498620 0.06 ENST00000399788.2
ENST00000382815.4
lysine (K)-specific demethylase 5A
chr2_-_77749474 0.05 ENST00000409093.1
ENST00000409088.3
leucine rich repeat transmembrane neuronal 4
chr10_+_45495898 0.05 ENST00000298299.3
zinc finger protein 22
chrX_-_53350522 0.05 ENST00000396435.3
ENST00000375368.5
IQ motif and Sec7 domain 2
chr21_-_19858196 0.04 ENST00000422787.1
transmembrane protease, serine 15
chr11_+_126262027 0.04 ENST00000526311.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
chr13_+_42712178 0.04 ENST00000536612.1
diacylglycerol kinase, eta
chr20_+_54987168 0.03 ENST00000360314.3
Cas scaffolding protein family member 4
chr17_-_67057114 0.03 ENST00000370732.2
ATP-binding cassette, sub-family A (ABC1), member 9
chr19_-_14628645 0.03 ENST00000598235.1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr18_+_74240610 0.02 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
long intergenic non-protein coding RNA 908
chr3_+_151531810 0.02 ENST00000232892.7
arylacetamide deacetylase
chr22_-_17702729 0.02 ENST00000449907.2
ENST00000441548.1
ENST00000399839.1
cat eye syndrome chromosome region, candidate 1
chr19_+_3136115 0.01 ENST00000262958.3
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chrX_+_128674213 0.01 ENST00000371113.4
ENST00000357121.5
oculocerebrorenal syndrome of Lowe
chrX_-_18238999 0.01 ENST00000380033.4
ENST00000380030.3
BEN domain containing 2
chr1_+_156119466 0.01 ENST00000414683.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_-_196242233 0.01 ENST00000397537.2
single-pass membrane protein with coiled-coil domains 1
chr16_+_72090053 0.01 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
haptoglobin
chr5_+_140201183 0.00 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
protocadherin alpha 5
chr1_+_40942887 0.00 ENST00000372706.1
ZFP69 zinc finger protein
chrY_+_16168097 0.00 ENST00000250823.4
variable charge, Y-linked 1B

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0071494 cellular response to UV-C(GO:0071494)
0.2 0.7 GO:0061580 colon epithelial cell migration(GO:0061580)
0.2 2.9 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 0.3 GO:0070638 nicotinamide riboside catabolic process(GO:0006738) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.3 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 0.2 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.1 6.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 0.6 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 0.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.3 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.0 0.6 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.2 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.2 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.5 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.2 GO:0033133 positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.3 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.4 GO:0097179 protease inhibitor complex(GO:0097179)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.7 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.2 2.4 GO:0089720 caspase binding(GO:0089720)
0.1 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.3 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.2 GO:0015254 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1 0.2 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.9 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.1 GO:0001160 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.6 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.7 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.9 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions