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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SIX1_SIX3_SIX2
Z-value: 1.07
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Transcription factors associated with SIX1_SIX3_SIX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX1 | hg19_v2_chr14_-_61124977_61125037 | -0.74 | 2.6e-01 | Click! |
| SIX3 | hg19_v2_chr2_+_45168875_45168916 | -0.18 | 8.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_241695424 Show fit | 1.40 |
ENST00000366558.3
ENST00000366559.4 |
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr10_-_33405600 Show fit | 1.37 |
ENST00000414308.1
|
RP11-342D11.3 |
|
| chr1_+_241695670 Show fit | 1.33 |
ENST00000366557.4
|
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) |
|
| chr15_-_31521567 Show fit | 1.10 |
ENST00000560812.1
ENST00000559853.1 ENST00000558109.1 |
RP11-16E12.2 |
|
| chr13_-_46679144 Show fit | 0.97 |
ENST00000181383.4
|
carboxypeptidase B2 (plasma) |
|
| chr5_-_159846066 Show fit | 0.84 |
ENST00000519349.1
ENST00000520664.1 |
SLU7 splicing factor homolog (S. cerevisiae) |
|
| chr13_-_46679185 Show fit | 0.81 |
ENST00000439329.3
|
carboxypeptidase B2 (plasma) |
|
| chr16_-_28550320 Show fit | 0.76 |
ENST00000395641.2
|
nuclear protein, transcriptional regulator, 1 |
|
| chr7_+_139025875 Show fit | 0.65 |
ENST00000297534.6
|
chromosome 7 open reading frame 55 |
|
| chr6_-_136847099 Show fit | 0.64 |
ENST00000438100.2
|
microtubule-associated protein 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX1_SIX3_SIX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.4 | 1.8 | GO:0003331 | regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331) |
| 0.1 | 1.4 | GO:2000194 | regulation of female gonad development(GO:2000194) |
| 0.1 | 1.0 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.1 | 0.8 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.1 | 0.7 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.1 | 0.6 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.0 | 0.5 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 0.4 | GO:0002415 | immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0034385 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 0.6 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 0.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.0 | 0.4 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 0.3 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.0 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.3 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.3 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.2 | GO:0005846 | nuclear cap binding complex(GO:0005846) |
| 0.0 | 0.2 | GO:0033263 | CORVET complex(GO:0033263) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 1.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.0 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 0.8 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 0.4 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.1 | 0.4 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.0 | 0.4 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.0 | 0.4 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 0.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 0.3 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.2 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.0 | 0.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |