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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for SIN3A_CHD1
Z-value: 1.89
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Transcription factors associated with SIN3A_CHD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIN3A | hg19_v2_chr15_-_75743991_75744011 | 0.64 | 3.6e-01 | Click! |
| CHD1 | hg19_v2_chr5_-_98262240_98262240 | 0.57 | 4.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_78740511 Show fit | 2.70 |
ENST00000504123.1
ENST00000264903.4 ENST00000515441.1 |
CCR4-NOT transcription complex, subunit 6-like |
|
| chr17_+_68165657 Show fit | 1.53 |
ENST00000243457.3
|
potassium inwardly-rectifying channel, subfamily J, member 2 |
|
| chr6_-_29600559 Show fit | 1.45 |
ENST00000476670.1
|
gamma-aminobutyric acid (GABA) B receptor, 1 |
|
| chr19_+_1286097 Show fit | 1.28 |
ENST00000215368.2
|
ephrin-A2 |
|
| chr3_+_19988736 Show fit | 1.08 |
ENST00000443878.1
|
RAB5A, member RAS oncogene family |
|
| chr7_-_27239703 Show fit | 0.88 |
ENST00000222753.4
|
homeobox A13 |
|
| chr2_-_178129551 Show fit | 0.88 |
ENST00000430047.1
|
nuclear factor, erythroid 2-like 2 |
|
| chr3_-_88108212 Show fit | 0.87 |
ENST00000482016.1
|
CGG triplet repeat binding protein 1 |
|
| chr11_-_33891362 Show fit | 0.81 |
ENST00000395833.3
|
LIM domain only 2 (rhombotin-like 1) |
|
| chr10_+_28822236 Show fit | 0.81 |
ENST00000347934.4
ENST00000354911.4 |
WW domain containing adaptor with coiled-coil |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIN3A_CHD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.9 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.6 | 2.5 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.1 | 2.2 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 2.1 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.4 | 1.5 | GO:0090076 | relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 1.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.1 | 1.5 | GO:0035246 | peptidyl-arginine N-methylation(GO:0035246) |
| 0.2 | 1.1 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 1.1 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 1.1 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.2 | 2.1 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.0 | 2.0 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.5 | 1.8 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.2 | 1.4 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.1 | 1.1 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
| 0.0 | 1.1 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 1.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 1.0 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.1 | 0.9 | GO:0033503 | HULC complex(GO:0033503) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 2.6 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 2.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 2.1 | GO:0004407 | histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558) |
| 0.4 | 1.8 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.0 | 1.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 1.6 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 1.5 | GO:0016273 | arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274) |
| 0.0 | 1.5 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 1.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 1.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 1.2 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.0 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 2.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 2.0 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 1.9 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.2 | 1.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 1.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.0 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 0.9 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |