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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for RUNX3_BCL11A
Z-value: 1.37
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Transcription factors associated with RUNX3_BCL11A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL11A | hg19_v2_chr2_-_60780536_60780541 | 0.72 | 2.8e-01 | Click! |
| RUNX3 | hg19_v2_chr1_-_25291475_25291511 | -0.40 | 6.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_34417479 Show fit | 2.58 |
ENST00000225245.5
|
chemokine (C-C motif) ligand 3 |
|
| chr19_+_10197463 Show fit | 1.22 |
ENST00000590378.1
ENST00000397881.3 |
chromosome 19 open reading frame 66 |
|
| chr3_+_136676707 Show fit | 0.99 |
ENST00000329582.4
|
interleukin 20 receptor beta |
|
| chr15_-_60695071 Show fit | 0.95 |
ENST00000557904.1
|
annexin A2 |
|
| chr15_+_67390920 Show fit | 0.84 |
ENST00000559092.1
ENST00000560175.1 |
SMAD family member 3 |
|
| chr3_+_136676851 Show fit | 0.84 |
ENST00000309741.5
|
interleukin 20 receptor beta |
|
| chr12_-_56753858 Show fit | 0.83 |
ENST00000314128.4
ENST00000557235.1 ENST00000418572.2 |
signal transducer and activator of transcription 2, 113kDa |
|
| chr4_+_71091786 Show fit | 0.72 |
ENST00000317987.5
|
follicular dendritic cell secreted protein |
|
| chr6_+_45296391 Show fit | 0.72 |
ENST00000371436.6
ENST00000576263.1 |
runt-related transcription factor 2 |
|
| chr4_-_57976544 Show fit | 0.72 |
ENST00000295666.4
ENST00000537922.1 |
insulin-like growth factor binding protein 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.5 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 0.4 | 1.7 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 0.2 | 1.1 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.2 | 1.0 | GO:0052418 | multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419) |
| 0.1 | 0.8 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.8 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.0 | 0.8 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.0 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.2 | 0.7 | GO:1903770 | regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208) negative regulation of single strand break repair(GO:1903517) negative regulation of beta-galactosidase activity(GO:1903770) telomere single strand break repair(GO:1903823) negative regulation of telomere single strand break repair(GO:1903824) |
| 0.1 | 0.7 | GO:0051414 | response to cortisol(GO:0051414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.2 | 1.0 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
| 0.1 | 0.9 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.6 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 0.6 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.5 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.5 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.6 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 2.0 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.3 | 1.9 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.2 | 1.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 1.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 0.9 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.1 | 0.9 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 0.8 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.8 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.7 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 0.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.4 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.0 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.8 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.8 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.7 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.0 | 0.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |