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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for RORA
Z-value: 1.54
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Transcription factors associated with RORA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RORA | hg19_v2_chr15_-_61521495_61521518 | 0.97 | 3.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_49140609 Show fit | 1.78 |
ENST00000601104.1
|
D site of albumin promoter (albumin D-box) binding protein |
|
| chr1_+_229440129 Show fit | 1.36 |
ENST00000366688.3
|
S-phase response (cyclin related) |
|
| chr11_-_6462210 Show fit | 1.31 |
ENST00000265983.3
|
hemopexin |
|
| chr1_-_150207017 Show fit | 1.30 |
ENST00000369119.3
|
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
|
| chr10_+_102729249 Show fit | 1.15 |
ENST00000519649.1
ENST00000518124.1 |
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G |
|
| chr11_+_86502085 Show fit | 1.10 |
ENST00000527521.1
|
protease, serine, 23 |
|
| chr11_-_69867159 Show fit | 1.02 |
ENST00000528507.1
|
RP11-626H12.2 |
|
| chr17_-_27503770 Show fit | 0.90 |
ENST00000533112.1
|
myosin XVIIIA |
|
| chrX_-_30327495 Show fit | 0.81 |
ENST00000453287.1
|
nuclear receptor subfamily 0, group B, member 1 |
|
| chr11_-_17555421 Show fit | 0.81 |
ENST00000526181.1
|
Usher syndrome 1C (autosomal recessive, severe) |
Network of associatons between targets according to the STRING database.
First level regulatory network of RORA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
| 0.1 | 1.3 | GO:0030091 | protein repair(GO:0030091) |
| 0.0 | 1.3 | GO:0043486 | histone exchange(GO:0043486) |
| 0.2 | 1.2 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 1.2 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 1.2 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 1.0 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.3 | 0.9 | GO:0002368 | B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.2 | 0.9 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.2 | 0.8 | GO:1904106 | protein localization to microvillus(GO:1904106) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 1.9 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 1.3 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 1.3 | GO:0032420 | stereocilium(GO:0032420) |
| 0.2 | 1.2 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.1 | 0.9 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 0.8 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 0.7 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.2 | 0.7 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.2 | 1.3 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.1 | 1.3 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 1.2 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.0 | 1.2 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.0 | 1.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.9 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.0 | 0.8 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.2 | 0.7 | GO:0050567 | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567) |
| 0.1 | 0.7 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.0 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 1.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.4 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.9 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.7 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.7 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.6 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 0.6 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |