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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)

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Results for RFX5

Z-value: 0.70

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319283_1513193140.954.9e-02Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_32812568 0.80 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr3_-_27410847 0.54 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
NEK10
NIMA-related kinase 10
chr6_+_32821924 0.51 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 0.49 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_26383318 0.44 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_+_26383404 0.43 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr1_-_208417620 0.42 ENST00000367033.3
PLXNA2
plexin A2
chr16_+_67381263 0.42 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr6_+_26458152 0.41 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr6_+_26458171 0.36 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr6_-_32812420 0.36 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr17_+_27052892 0.29 ENST00000579671.1
ENST00000579060.1
NEK8
NIMA-related kinase 8
chr19_-_49118067 0.29 ENST00000593772.1
FAM83E
family with sequence similarity 83, member E
chr19_-_6057282 0.28 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr1_+_114473350 0.27 ENST00000503968.1
HIPK1
homeodomain interacting protein kinase 1
chr12_-_123565834 0.27 ENST00000546049.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr5_-_149792295 0.27 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr3_+_66271410 0.26 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr19_+_36103631 0.26 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr17_+_38137050 0.26 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_+_249132512 0.25 ENST00000505503.1
ZNF672
zinc finger protein 672
chr19_+_45418067 0.25 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr5_+_119799927 0.24 ENST00000407149.2
ENST00000379551.2
PRR16
proline rich 16
chr17_-_19266045 0.23 ENST00000395616.3
B9D1
B9 protein domain 1
chr19_+_45417921 0.23 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr2_-_242088850 0.22 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr6_-_32557610 0.22 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr3_+_66271489 0.22 ENST00000536651.1
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr17_-_19265982 0.22 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr11_-_72433346 0.19 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr22_-_30987837 0.19 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr6_-_32784687 0.18 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_-_19265855 0.18 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr1_-_27339317 0.16 ENST00000289166.5
FAM46B
family with sequence similarity 46, member B
chr16_+_57844549 0.16 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr1_+_36549676 0.13 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr12_-_110841462 0.12 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chr3_+_43328004 0.12 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr2_+_242089046 0.11 ENST00000407025.1
ENST00000272983.8
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr3_+_9851558 0.10 ENST00000430718.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr1_+_46049706 0.10 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
NASP
nuclear autoantigenic sperm protein (histone-binding)
chr5_-_55412774 0.09 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chrX_+_19362011 0.09 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr11_+_45868957 0.08 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr1_-_202936394 0.08 ENST00000367249.4
CYB5R1
cytochrome b5 reductase 1
chr7_+_766320 0.07 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr20_+_306221 0.07 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr20_+_306177 0.06 ENST00000544632.1
SOX12
SRY (sex determining region Y)-box 12
chr11_-_118436707 0.06 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr4_-_143226979 0.05 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr6_-_30181133 0.04 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr16_-_74808710 0.04 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr19_+_19496728 0.04 ENST00000537887.1
ENST00000417582.2
GATAD2A
GATA zinc finger domain containing 2A
chr1_+_249132462 0.04 ENST00000306562.3
ZNF672
zinc finger protein 672
chr11_+_111385497 0.04 ENST00000375618.4
ENST00000529167.1
ENST00000332814.6
C11orf88
chromosome 11 open reading frame 88
chr6_+_26365443 0.03 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr19_+_10527449 0.03 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr6_-_30658745 0.03 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr2_-_201599892 0.02 ENST00000452787.1
AC007163.3
AC007163.3
chr20_+_42875887 0.01 ENST00000342560.5
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr11_-_85430088 0.01 ENST00000533057.1
ENST00000533892.1
SYTL2
synaptotagmin-like 2
chr2_+_242088963 0.01 ENST00000438799.1
ENST00000402734.1
ENST00000423280.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr6_-_30181156 0.01 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr19_+_10563567 0.01 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_51014345 0.01 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr10_-_82116505 0.01 ENST00000372202.1
ENST00000421924.2
ENST00000453477.1
DYDC1
DPY30 domain containing 1
chr2_+_173600565 0.00 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.5 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.1 0.2 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.1 0.3 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 0.5 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.9 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.4 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 1.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.3 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.3 GO:0001675 acrosome assembly(GO:0001675)
0.0 0.2 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.5 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.0 GO:0042613 MHC class II protein complex(GO:0042613)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.5 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.5 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 1.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0032395 MHC class II receptor activity(GO:0032395)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway