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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for RFX3_RFX2
Z-value: 2.44
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX3 | hg19_v2_chr9_-_3489428_3489437 | 0.94 | 6.1e-02 | Click! |
| RFX2 | hg19_v2_chr19_-_6110555_6110617 | 0.89 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.7 | 2.2 | GO:0070512 | regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512) |
| 0.0 | 1.8 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 1.7 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.2 | 1.6 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 0.1 | 1.6 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.2 | 1.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 0.0 | 1.5 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.1 | 1.4 | GO:0035721 | intraciliary retrograde transport(GO:0035721) |
| 0.1 | 1.4 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.5 | 2.2 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.0 | 2.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.6 | 1.7 | GO:1990716 | axonemal central apparatus(GO:1990716) |
| 0.1 | 1.7 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.2 | 1.6 | GO:0005818 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 1.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 1.3 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 1.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 2.3 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.0 | 2.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 1.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.0 | 1.2 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.2 | GO:0016279 | protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.1 | 1.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 1.1 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 1.0 | GO:0031812 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.1 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 1.0 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.5 | ST ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 2.2 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 1.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 1.4 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.0 | 1.2 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 1.2 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 0.9 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.8 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |