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A549 cells infected with RSV Analysis Results (GEO series: GSE147507)
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Results for RELA
Z-value: 3.04
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65429891_65429915 | 0.82 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_62203808 Show fit | 4.38 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr6_+_138188351 Show fit | 4.37 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr2_-_191885686 Show fit | 4.28 |
ENST00000432058.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr9_-_21077939 Show fit | 3.78 |
ENST00000380232.2
|
interferon, beta 1, fibroblast |
|
| chr14_-_35873856 Show fit | 3.56 |
ENST00000553342.1
ENST00000216797.5 ENST00000557140.1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
| chr17_-_34207295 Show fit | 3.26 |
ENST00000463941.1
ENST00000293272.3 |
chemokine (C-C motif) ligand 5 |
|
| chr6_+_29691056 Show fit | 3.19 |
ENST00000414333.1
ENST00000334668.4 ENST00000259951.7 |
major histocompatibility complex, class I, F |
|
| chr19_+_39759154 Show fit | 3.18 |
ENST00000331982.5
|
interferon, lambda 2 |
|
| chr6_+_138188551 Show fit | 3.10 |
ENST00000237289.4
ENST00000433680.1 |
tumor necrosis factor, alpha-induced protein 3 |
|
| chr6_+_29691198 Show fit | 3.02 |
ENST00000440587.2
ENST00000434407.2 |
major histocompatibility complex, class I, F |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.4 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.4 | 9.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.5 | 7.5 | GO:0052250 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.7 | 6.8 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 1.4 | 5.4 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.1 | 4.4 | GO:0002268 | follicular dendritic cell differentiation(GO:0002268) |
| 1.1 | 4.3 | GO:0072308 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.4 | 4.3 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.6 | 3.8 | GO:0002725 | negative regulation of T cell cytokine production(GO:0002725) |
| 0.1 | 3.8 | GO:0071498 | cellular response to fluid shear stress(GO:0071498) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.8 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.6 | 6.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 1.1 | 4.4 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 3.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 2.7 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 2.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 2.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 2.3 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 2.2 | GO:0031674 | I band(GO:0031674) |
| 0.3 | 2.1 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 10.8 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 10.1 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.5 | 7.0 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.9 | 6.2 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.0 | 5.4 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 5.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 4.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 4.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.8 | 3.8 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 3.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.2 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.6 | 7.9 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.2 | 5.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 2.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 1.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 11.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 10.9 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.5 | 10.5 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.7 | 6.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.3 | 6.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 4.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 3.1 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 2.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 2.3 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |